gene

JAG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Comprehensive coverage of JAG1 in Notch signaling, neurodevelopment, Alzheimer's disease, and Notch ligand biology in neurodegeneration

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🧬 Gene Info

Gene Symbol	JAG1
Full Name	Jagged 1
Chromosome	20p12.2
Function	is a critical member of the Notch ligand family that plays essential roles in cell fate determination, embryonic development, tissue homeostasis, and increasingly recognized functions in neurodegen...
Primary Expression	Cerebral cortex, Cochlea, Liver, Heart
Molecular Weight	134 kDa
Amino Acids	218 aa
Pathways	Notch, NOTCH, Notch signaling
UniProt ID	P78504
NCBI Gene ID	1950
Ensembl ID	ENSG00000101384
OMIM	184756
GeneCards	JAG1
Human Protein Atlas	JAG1
Associated Diseases	ALS, neurodegeneration
Interactions	APOPTOSIS, AUTOPHAGY, NOTCH, NOTCH1, Rb, RNA
KG Connections	180 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: JAG1 — AlphaFold P78504 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

JAG1 — Jagged 1

gene · 1775 words

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JAG1 Protein

protein · 1218 words

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Pathway Diagram

flowchart TD
    JAG1["JAG1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    JAG1["JAG1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    JAG1["JAG1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    JAG1["JAG1"] -->|"therapeutic target"| Cancer["Cancer"]
    JAG1["JAG1"] -->|"therapeutic target"| Als["Als"]
    JAG1["JAG1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    JAG1["JAG1"] -->|"therapeutic target"| Ms["Ms"]
    JAG1["JAG1"] -->|"therapeutic target"| Cardiac["Cardiac"]
    JAG1["JAG1"] -->|"therapeutic target"| MITF["MITF"]
    JAG1["JAG1"] -->|"therapeutic target"| GAIN["GAIN"]
    JAG1["JAG1"] -->|"therapeutic target"| AXIN2["AXIN2"]
    JAG1["JAG1"] -->|"therapeutic target"| CD44["CD44"]
    style JAG1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style MITF fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style GAIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style AXIN2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style CD44 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (116)

Target	Relation	Type	Str
Apoptosis	mediates	process	0.90
Autophagy	associated_with	process	0.90
Prostate Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Notch signaling	participates_in	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Als	activates	disease	0.65
ALS	activates	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
NRCAM	targets	gene	0.60
TERT	targets	gene	0.60
NOTCH2	targets	gene	0.60
NEUROD1	targets	gene	0.60
VEGFA	targets	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
BRG1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
NOTCH2	associated_with	gene	0.60
BMP2	therapeutic_target	gene	0.60
Osteoblast	activates	cell_type	0.60
GENES	therapeutic_target	gene	0.60
ROS	inhibits	gene	0.60
MYC	targets	gene	0.60
Metastasis	therapeutic_target	pathway	0.60
Notch	interacts_with	pathway	0.60
Tumor Microenvironment	interacts_with	pathway	0.60
Angiogenesis	therapeutic_target	pathway	0.60
RNA	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60

Incoming (64)

Source	Relation	Type	Str
HSV-1	upregulates	disease	0.92
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
NOTCH1	inhibits	gene	0.60
BAMBI	targets	gene	0.60
ATF3	targets	gene	0.60
CD44	targets	gene	0.60
CDH1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
ROS	inhibits	gene	0.60
NOTCH	inhibits	gene	0.60
DKK1	targets	gene	0.60
ICAM1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
TDP-43	expressed_in	gene	0.60
SYP	expressed_in	gene	0.60
ICAM5	expressed_in	gene	0.60
PENK	expressed_in	gene	0.60
TCR	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
RNA	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
FGF20	targets	gene	0.60
ABCB1	targets	gene	0.60
FZD7	targets	gene	0.60
CREBBP	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
ULK1	inhibits	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
ITGB8	targets	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JAG1 in their description or question text

No additional research found