concept

CLDN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLDN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

307Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CLDN1 is a concept in neurodegeneration research. Key relationships include: therapeutic target, expressed in, activates. Associated with ALS, Als, Atherosclerosis. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CLDN1
Key Genes/Proteins	AADC, ABCB1, AHR, ALDH1A1, AND, APC
Related Diseases	Als, ALS, ALZHEIMER, anxiety, Atherosclerosis

🔮 Predicted Structure: CLDN1 — AlphaFold O95832 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    CLDN1["CLDN1"]
    CLDN1 -->|"activates"| Ms["Ms"]
    CLDN1 -->|"activates"| Inflammation["Inflammation"]
    CLDN1 -->|"inhibits"| Als["Als"]
    CLDN1 -->|"target for"| Fibrosis["Fibrosis"]
    CLDN1 -->|"target for"| Hepatitis["Hepatitis"]
    CLDN1 -->|"target for"| Carcinoma["Carcinoma"]
    CLDN1 -->|"target for"| Cancer["Cancer"]
    h_6c83282d["h-6c83282d"] -->|"targets"| CLDN1
    IL4["IL4"] -->|"inhibits"| CLDN1
    IL13["IL13"] -->|"inhibits"| CLDN1
    OCLN["OCLN"] -->|"activates"| CLDN1
    TNF["TNF"] -->|"activates"| CLDN1
    FGF20["FGF20"] -->|"target for"| CLDN1
    BRG1["BRG1"] -->|"target for"| CLDN1
    NRCAM["NRCAM"] -->|"target for"| CLDN1
    NOTCH2["NOTCH2"] -->|"target for"| CLDN1
    EP300["EP300"] -->|"target for"| CLDN1

Outgoing (211)

Target	Relation	Type	Str
cancer stemness	promotes	phenotype	0.95
EPHA2	interacts_with	protein	0.95
chemoresistance	promotes	phenotype	0.95
EPHA2	inhibits	protein	0.90
Epidermal Barrier Function	associated_with	phenotype	0.85
Glioma Progression	downregulates	process	0.85
OCLN	associated_with	gene	0.80
Glioma	downregulates	disease	0.80
blood-brain barrier integrity	mediates	phenotype	0.75
Hepatocellular Carcinoma	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Hepatitis	therapeutic_target	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
neural stem cells	inhibits	cell_type	0.70
neural stem cells	regulates	cell_type	0.70
Glioblastoma Multiforme	biomarker_for	disease	0.70
Glioblastoma Multiforme	suppresses	disease	0.70
ALS	inhibits	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatitis	regulates	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Als	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
ERK	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
ERK	expressed_in	gene	0.60
glioblastoma	expressed_in	disease	0.60
ALZHEIMER	associated_with	disease	0.60
CANCER	activates	disease	0.60
ATF3	therapeutic_target	gene	0.60
LOR	regulates	gene	0.60
CLDN3	expressed_in	gene	0.60

Incoming (96)

Source	Relation	Type	Str
Betulinic Acid	upregulates	compound	0.95
h-6c83282d	targets	hypothesis	0.90
Tralokinumab	upregulates	drug	0.88
Gallic Acid	upregulates	compound	0.88
IL4	inhibits	protein	0.72
IL13	inhibits	protein	0.72
CANCER	therapeutic_target	gene	0.70
ATF3	targets	gene	0.60
BAMBI	targets	gene	0.60
OCLN	associated_with	gene	0.60
CD81	therapeutic_target	gene	0.60
MLCK	activates	gene	0.60
ABCB1	targets	gene	0.60
STAT6	inhibits	gene	0.60
OCLN	expressed_in	gene	0.60
CREBBP	therapeutic_target	gene	0.60
IFNG	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
IL22	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
IL31	expressed_in	gene	0.60
NRF2	activates	gene	0.60
AXIN2	targets	gene	0.60
CD44	targets	gene	0.60
ALDH1A1	targets	gene	0.60
INFLAMMATION	activates	gene	0.60
IL-6	activates	gene	0.60
IL-4	inhibits	gene	0.60
IL-13	inhibits	gene	0.60
RNA	expressed_in	gene	0.60
IL4R	expressed_in	gene	0.60
IL-13	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
FGF20	therapeutic_target	gene	0.60
IL-10	activates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CLDN1 in their description or question text

No additional research found