gene

FOXM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

178Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

FOXM1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Als, Cancer, Carcinoma. Connected to 150 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXM1
Chromosome	12p13.33
Protein Type	Transcription Factor
Function	FOXM1 is a key transcriptional regulator of cell cycle and DNA repair genes[@koo2012]:
Molecular Weight	82 kDa
Amino Acids	664 aa
Pathways	Chemoresistance, Complement, Epigenetic, Hedgehog, Nf-Κb
GeneCards	FOXM1
Human Protein Atlas	FOXM1
Associated Diseases	Cancer, Carcinoma, Lung Cancer, Melanoma, Tumor
Interactions	AKT, AND, APOPTOSIS, AUTOPHAGY, CANCER, FOXO3
KG Connections	178 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FOXM1 Gene

gene · 1234 words

→

FOXM1 Protein

protein · 699 words

→

Pathway Diagram

graph TD
    FOXM1["FOXM1"]
    FOXM1 -->|"regulates"| BUB1B["BUB1B"]
    FOXM1 -->|"downregulates"| IGF_1R_["IGF-1Rbeta"]
    FOXM1 -->|"target for"| Fibrosis["Fibrosis"]
    FOXM1 -->|"target for"| Hepatitis["Hepatitis"]
    FOXM1 -->|"target for"| Carcinoma["Carcinoma"]
    FOXM1 -->|"target for"| Cancer["Cancer"]
    FOXM1 -->|"target for"| Als["Als"]
    FOXM1 -->|"target for"| Inflammation["Inflammation"]
    FOXM1 -->|"target for"| Ms["Ms"]
    FOXM1 -->|"expressed in"| Diabetes["Diabetes"]
    SMC1A["SMC1A"] -->|"upregulates"| FOXM1
    HNRNPD["HNRNPD"] -->|"upregulates"| FOXM1
    NEDD4_1["NEDD4-1"] -->|"upregulates"| FOXM1
    YAP["YAP"] -->|"upregulates"| FOXM1
    TRIB3["TRIB3"] -->|"regulates"| FOXM1
    FGF20["FGF20"] -->|"target for"| FOXM1
    BRG1["BRG1"] -->|"regulates"| FOXM1
    NRCAM["NRCAM"] -->|"target for"| FOXM1
    NOTCH2["NOTCH2"] -->|"target for"| FOXM1

Outgoing (104)

Target	Relation	Type	Str
Cancer	regulates	disease	0.75
Diabetes	expressed_in	disease	0.65
Carcinoma	regulates	disease	0.65
Melanoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Leukemia	inhibits	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
MUC1	regulates	gene	0.60
MUC16	regulates	gene	0.60
CANCER	regulates	gene	0.60
Chemoresistance	regulates	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
Apoptosis	activates	pathway	0.60
VEGFA	therapeutic_target	gene	0.60
HSP70	regulates	gene	0.60
Ras	associated_with	protein	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	regulates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
RB1	regulates	gene	0.60
RHOT1	binds_to	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	inhibits	gene	0.60
IL6	associated_with	gene	0.60

Incoming (74)

Source	Relation	Type	Str
HNRNPD	upregulates	protein	0.80
SRC	regulates	gene	0.60
BAG3	regulates	gene	0.60
GAIN	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
AKT	inhibits	gene	0.60
FOXO1	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
FOXA2	associated_with	gene	0.60
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
SHH	regulates	gene	0.60
FOXP1	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
MICRORNAS	expressed_in	gene	0.60
NF-ΚB	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
RELN	regulates	gene	0.60
MYC	regulates	gene	0.60
ERBB4	regulates	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
AXIN1	regulates	gene	0.60
CD44	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
SMARCA4	regulates	gene	0.60
TERT	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
APC	regulates	gene	0.60
CREBBP	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FOXM1 in their description or question text

No additional research found