protein

BRG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

229Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BRG1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with Als, Cancer, Carcinoma. Connected to 122 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BRG1 (SMARCA4)
Full Name	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin
Chromosome	19q13.2
Function	SMARCA4 encodes the central ATPase of the SWI/SNF complex.
Primary Expression	neural progenitors, increases with differentiation
Molecular Weight	185 kDa
Pathways	Epigenetic
UniProt ID	P51532
NCBI Gene ID	6597
Ensembl ID	ENSG00000127616
OMIM	603254
Associated Diseases	Cancer, Colorectal Cancer, Inflammatory Bowel Disease, Tumor
Known Drugs/Compounds	rapamycin
Interactions	AKT, ASC, ATG, BECLIN1, BECN1, BMAL1
KG Connections	229 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BRG1 — AlphaFold P51532 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    BRG1["BRG1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    BRG1["BRG1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    BRG1["BRG1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    BRG1["BRG1"] -->|"therapeutic target"| Cancer["Cancer"]
    BRG1["BRG1"] -->|"therapeutic target"| Als["Als"]
    BRG1["BRG1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    BRG1["BRG1"] -->|"therapeutic target"| Ms["Ms"]
    BRG1["BRG1"] -->|"expressed in"| Als["Als"]
    BRG1["BRG1"] -->|"expressed in"| Cancer["Cancer"]
    BRG1["BRG1"] -->|"therapeutic target"| NRCAM["NRCAM"]
    BRG1["BRG1"] -->|"therapeutic target"| NOTCH2["NOTCH2"]
    BRG1["BRG1"] -->|"regulates"| EP300["EP300"]
    style BRG1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style NRCAM fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NOTCH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EP300 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (165)

Target	Relation	Type	Str
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Tumor	expressed_in	disease	0.65
Infection	activates	disease	0.65
Immune Response	activates	pathway	0.60
SWI	activates	gene	0.60
IFN	activates	gene	0.60
Epigenetic	activates	pathway	0.60
FGF20	therapeutic_target	gene	0.60
CLDN2	activates	gene	0.60
RALGAPA2	activates	gene	0.60
SNF	activates	gene	0.60
Microrna	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
Unfolded Protein Response	associated_with	pathway	0.60
MAPK	associated_with	gene	0.60
NRBF2	associated_with	gene	0.60
AND	associated_with	gene	0.60
Neurogenesis	expressed_in	pathway	0.60
AKT	inhibits	gene	0.60
CDH1	regulates	gene	0.60
GENES	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
Wnt	therapeutic_target	pathway	0.60
Epigenetic	regulates	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Autophagy	expressed_in	pathway	0.60
IKK	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60

Incoming (64)

Source	Relation	Type	Str
BAMBI	therapeutic_target	gene	0.60
TNF-Α	activates	gene	0.60
AND	therapeutic_target	gene	0.60
FBXW7	inhibits	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IL-6	activates	gene	0.60
CANCER	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	regulates	gene	0.60
ULK1	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
FGF20	therapeutic_target	gene	0.60
ATF2	regulates	gene	0.60
AMBRA1	regulates	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
CTNNB1	regulates	gene	0.60
AXIN1	regulates	gene	0.60
EP300	regulates	gene	0.60
CREBBP	regulates	gene	0.60
FGF18	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
LC3	associated_with	gene	0.60
NLR	associated_with	gene	0.60
TNF	activates	gene	0.60
IL6	activates	gene	0.60
KDM2B	activates	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60
ASC	activates	gene	0.60
APC	regulates	gene	0.60
AXIN2	regulates	gene	0.60
RIPK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
ASC	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
PTEN	expressed_in	gene	0.60
PI3K	therapeutic_target	gene	0.60
BMAL1	activates	gene	0.55
Pi3K	activates	pathway	0.50
mTOR	activates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BRG1 in their description or question text

No additional research found