Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DKK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DKK1 encodes a secreted Wnt pathway inhibitor with critical roles in development, bone homeostasis, and neurodegenerative diseases
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| Gene Symbol | DKK1 |
| Full Name | Dickkopf WNT Signaling Pathway Inhibitor 1 |
| Chromosome | 10q21.1 |
| Function | This prevents formation of the Wnt-Frizzled-LRP5/6 ternary complex and downstream β-catenin stabilization. |
| Primary Expression | Brain (low), Bone, Kidney, Liver |
| Amino Acids | 305 aa |
| Pathways | WNT Signaling, Wnt Signaling, Wnt, Wnt signaling |
| UniProt ID | O94907 |
| NCBI Gene ID | 2698 |
| Ensembl ID | ENSG00000107957 |
| OMIM | 605386 |
| GeneCards | DKK1 |
| Human Protein Atlas | DKK1 |
| Associated Diseases | Alzheimer, dementia, depression |
| Interactions | AND, App, DNMT1, JNK, Leptin, NESTIN |
| KG Connections | 163 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
DKK1["DKK1"] -.->|"inhibits"| Wnt_signaling_pathway["Wnt signaling pathway"]
ESRRA["ESRRA"] -->|"regulates"| DKK1["DKK1"]
ESRRG["ESRRG"] -->|"regulates"| DKK1["DKK1"]
DKK1["DKK1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
DKK1["DKK1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
DKK1["DKK1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
DKK1["DKK1"] -->|"therapeutic target"| Cancer["Cancer"]
DKK1["DKK1"] -->|"therapeutic target"| Als["Als"]
DKK1["DKK1"] -->|"therapeutic target"| Inflammation["Inflammation"]
DKK1["DKK1"] -->|"therapeutic target"| Ms["Ms"]
DKK1["DKK1"] -->|"activates"| Carcinoma["Carcinoma"]
DKK1["DKK1"] -->|"activates"| Cancer["Cancer"]
style DKK1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Wnt_signaling_pathway fill:#1b5e20,stroke:#333,color:#e0e0e0
style ESRRA fill:#4a1a6b,stroke:#333,color:#e0e0e0
style ESRRG fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| WNT | inhibits | pathway | 0.90 |
| Wnt signaling pathway | inhibits | pathway | 0.70 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Lung Cancer | regulates | disease | 0.65 |
| Myocardial Infarction | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Hepatitis | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.65 |
| Colorectal Cancer | therapeutic_target | disease | 0.65 |
| Liver Cancer | therapeutic_target | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Pulmonary Fibrosis | therapeutic_target | disease | 0.65 |
| Lung Cancer | therapeutic_target | disease | 0.65 |
| Pancreatic Cancer | therapeutic_target | disease | 0.65 |
| Gastric Cancer | therapeutic_target | disease | 0.65 |
| Infection | therapeutic_target | disease | 0.65 |
| Prostate Cancer | therapeutic_target | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Obesity | inhibits | disease | 0.65 |
| Neuron | inhibits | cell_type | 0.60 |
| Wnt signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| SP1 | inhibits | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| depression | associated_with | disease | 0.60 |
| Lipid Metabolism | inhibits | pathway | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| BAMBI | therapeutic_target | gene | 0.60 |
| Ferroptosis | associated_with | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| Wnt | associated_with | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| Amyloid-Beta | associated_with | protein | 0.60 |
| dementia | associated_with | disease | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| EOMES | targets | gene | 0.60 |
| TNFRSF19 | targets | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| JNK | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ESRRA | regulates | gene | 0.70 |
| ESRRG | regulates | gene | 0.70 |
| WNT | inhibits | gene | 0.70 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| WNT | targets | gene | 0.60 |
| ABCB1 | targets | gene | 0.60 |
| AXIN2 | targets | gene | 0.60 |
| CD44 | targets | gene | 0.60 |
| ALDH1A1 | targets | gene | 0.60 |
| ATF3 | targets | gene | 0.60 |
| CLDN1 | targets | gene | 0.60 |
| AXIN1 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| APC | therapeutic_target | gene | 0.60 |
| CREBBP | therapeutic_target | gene | 0.60 |
| PTGS2 | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| CDH1 | therapeutic_target | gene | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| AMYLOID-BETA | associated_with | gene | 0.60 |
| SP1 | inhibits | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| NATURAL COMPOUNDS | regulates | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| FERROPTOSIS | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| BAMBI | targets | gene | 0.60 |
| NESTIN | inhibits | gene | 0.60 |
| CCND1 | targets | gene | 0.60 |
| CTLA4 | targets | gene | 0.60 |
| FGF20 | therapeutic_target | gene | 0.60 |
| BRG1 | therapeutic_target | gene | 0.60 |
| NRCAM | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| EP300 | therapeutic_target | gene | 0.60 |
| CTNNB1 | therapeutic_target | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| FOXM1 | therapeutic_target | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| SMARCA4 | therapeutic_target | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| FZD7 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DKK1 in their description or question text
No additional research found