gene

MITF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MITF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

239Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

MITF (Microphthalmia-Associated Transcription Factor) - microglia transcription factor controlling lysosomal biogenesis and phagocytosis, part of MITF/TFEB/TFE3/TFEC family

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🧬 Gene Info

Gene Symbol	MITF
Full Name	Microphthalmia-Associated Transcription Factor
Chromosome	3p13
Protein Family	bHLH-Zip (MITF/TFEB/TFE3/TFEC)
Function	Lysosomal biogenesis, phagocytosis, melanogenesis
Primary Expression	Melanocytes, microglia, retinal pigment epithelium
Amino Acids	150 aa
Pathways	Dna Repair, Mapk, Pi3K/Akt
UniProt ID	O75030
NCBI Gene ID	4283
Ensembl ID	ENSG00000186766
OMIM	156845
GeneCards	MITF
Human Protein Atlas	MITF
LAMP1, LAMP2	Lysosomal membrane proteins
Associated Diseases	Als, Cancer, Melanoma, neurodegeneration, Ovarian Cancer
Interactions	Actin, AND, ATG16L1, ATG8, AUTOPHAGY, CGAS
SciDEX Hypotheses	MITF Acts as the Primary Transcriptional Effector
KG Connections	239 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MITF — AlphaFold O75030 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MITF Gene — Microphthalmia-Associated Transcription Factor

gene · 1979 words

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MITF Gene

gene · 675 words

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Pathway Diagram

graph TD
    MITF["MITF"]
    MITF -->|"target for"| Fibrosis["Fibrosis"]
    MITF -->|"target for"| Hepatitis["Hepatitis"]
    MITF -->|"target for"| Carcinoma["Carcinoma"]
    MITF -->|"target for"| Cancer["Cancer"]
    MITF -->|"target for"| Als["Als"]
    MITF -->|"target for"| Inflammation["Inflammation"]
    MITF -->|"target for"| Ms["Ms"]
    MITF -->|"inhibits"| Parkinson["Parkinson"]
    FGF20["FGF20"] -->|"target for"| MITF
    BRG1["BRG1"] -->|"target for"| MITF
    NRCAM["NRCAM"] -->|"target for"| MITF
    NOTCH2["NOTCH2"] -->|"target for"| MITF
    EP300["EP300"] -->|"target for"| MITF
    CTNNB1["CTNNB1"] -->|"target for"| MITF
    NEUROD1["NEUROD1"] -->|"target for"| MITF
    MYC["MYC"] -->|"target for"| MITF
    VEGFA["VEGFA"] -->|"target for"| MITF
    ABCB1["ABCB1"] -->|"target for"| MITF

Outgoing (139)

Target	Relation	Type	Str
Als	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Als	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
autophagy pathway	participates_in	pathway	0.70
INFLAMMATION	therapeutic_target	gene	0.70
CANCER	associated_with	gene	0.70
CANCER	therapeutic_target	gene	0.70
Autophagy	activates	pathway	0.70
Ms	regulates	disease	0.65
Aging	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Tumor	contributes_to	disease	0.65
Melanoma	regulates	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
ALS	activates	disease	0.65
Melanoma	associated_with	disease	0.65
Ovarian Cancer	associated_with	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
ALDH1A1	therapeutic_target	gene	0.60
CD44	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
AXIN2	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.60
EP300	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
Interferon	activates	protein	0.60
JAG1	therapeutic_target	gene	0.60
POT1	associated_with	gene	0.60

Incoming (100)

Source	Relation	Type	Str
STING	upregulates	protein	0.80
AGING	therapeutic_target	gene	0.60
GABA	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
PARKINSON	activates	gene	0.60
ATG8	activates	gene	0.60
AND	regulates	gene	0.60
DNA	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
CREB	activates	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
HDAC	inhibits	gene	0.60
FGF20	targets	gene	0.60
ABCB1	targets	gene	0.60
LEF1	targets	gene	0.60
FZD7	targets	gene	0.60
JAG1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
FGF18	targets	gene	0.60
IL10	targets	gene	0.60
AXIN2	targets	gene	0.60
CLDN1	targets	gene	0.60
DKK1	targets	gene	0.60
ATF3	targets	gene	0.60
CD44	targets	gene	0.60
CDKN2A	associated_with	gene	0.60
BAMBI	targets	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
FOXM1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
TFEB	regulates	gene	0.60
TFE3	regulates	gene	0.60
MTOR	activates	gene	0.60
TBK1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
LRRK2	activates	gene	0.60
KDM4A	associated_with	gene	0.60
FGFR3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
BICD2	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MITF Acts as the Primary Transcriptional Effector Downstream	0.444	neurodegeneration	How does HDAC1/2 deletion specifically e

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.444

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study shows HDAC1/2 deletion improves amyloid clearance and cognition,

closed · Rounds: 4 · Score: 0.95 · 2026-04-13

Related Research

Hypotheses and analyses mentioning MITF in their description or question text

No additional research found