protein

NEUROD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

134Connections

1Hypotheses

1Analyses

50Outgoing

48Incoming

0Experiments

1Debates

Summary

NEUROD1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with Als, Cancer, Carcinoma. Connected to 88 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	NEUROD1
Protein Type	Gene
Function	NEUROD1 is a basic helix-loop-helix (bHLH) transcription factor critical for neuronal development and differentiation
Amino Acids	396 aa
Pathways	Epigenetic
GeneCards	NEUROD1
Human Protein Atlas	NEUROD1
Neuronal differentiation	Activates genes required for neuronal maturation
Pancreatic β-cell development	Essential for insulin-producing β-cell formation
Synaptic plasticity	Regulates genes involved in synaptic function
Circadian rhythm	Part of the transcriptional feedback loop controlling circadian clocks
Associated Diseases	Cancer, Lung Cancer, Tumor
Interactions	ASCL1, GENES, KDM6A, NOTCH1, STING
KG Connections	128 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NEUROD1 Gene

gene · 565 words

→

NEUROD1 Protein

protein · 586 words

→

Pathway Diagram

flowchart TD
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Cancer["Cancer"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Als["Als"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| Ms["Ms"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| MYC["MYC"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| VEGFA["VEGFA"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| ABCB1["ABCB1"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| FOXM1["FOXM1"]
    NEUROD1["NEUROD1"] -->|"therapeutic target"| LEF1["LEF1"]
    style NEUROD1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style MYC fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style VEGFA fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style ABCB1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style FOXM1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LEF1 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
Ins2	regulates	gene	0.70
NF-kB binding at inflammatory gene enhancers	reduces	mechanism	0.70
astrocyte reprogramming	causes	process	0.70
NF-kB binding	reduces	mechanism	0.70
inflammatory gene enhancers	inhibits	process	0.70
A1 reactive astrocytes	reprograms	cell_type	0.70
Fibrosis	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Carcinoma	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Alzheimer	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
NRCAM	targets	gene	0.60
VEGFA	targets	gene	0.60
TERT	targets	gene	0.60
PPARD	targets	gene	0.60
PTGS2	targets	gene	0.60
NOTCH2	targets	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
FGF18	therapeutic_target	gene	0.60
ATF3	therapeutic_target	gene	0.60
IL10	therapeutic_target	gene	0.60
DKK1	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
ASCL1	associated_with	gene	0.60

Incoming (48)

Source	Relation	Type	Str
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
DKK1	targets	gene	0.60
FZD7	targets	gene	0.60
IL10	targets	gene	0.60
ASCL1	interacts_with	gene	0.60
CXCR4	regulates	gene	0.60
GAP43	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
FGF20	targets	gene	0.60
ASCL1	activates	gene	0.60
KDM6A	activates	gene	0.60
ALDH1A1	targets	gene	0.60
MITF	targets	gene	0.60
LEF1	targets	gene	0.60
ABCB1	targets	gene	0.60
CLDN1	targets	gene	0.60
JAG1	targets	gene	0.60
CD44	targets	gene	0.60
FGF18	targets	gene	0.60
MYC	targets	gene	0.60
CANCER	associated_with	gene	0.60
GENES	activates	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
BRAIN INJURY	expressed_in	gene	0.60
CCND1	targets	gene	0.60
CTLA4	targets	gene	0.60
EOMES	targets	gene	0.60
BRG1	therapeutic_target	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	therapeutic_target	gene	0.60
CTNNB1	therapeutic_target	gene	0.60
YAP1	associated_with	gene	0.60
HNF4A	regulates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
AXIN1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
PPARD	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
NEURON	implicated_in	gene	0.60
BAMBI	targets	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NeuroD1-Mediated Astrocyte Reprogramming Attenuates Neuroinf	0.650	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (1)

Scientific analyses that reference this entity

epigenetic reprogramming aging neurons

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.790

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Epigenetic reprogramming of aging neurons represents an active research focus wi

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

Related Research

Hypotheses and analyses mentioning NEUROD1 in their description or question text

No additional research found