gene

IL10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

588Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

IL10 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, expressed in. Associated with ALS, Als, Atherosclerosis. Connected to 210 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL10
Full Name	Interleukin 10
Chromosome	1q31.3
Protein Type	Ligand
Target Class	Ligand
Function	Recombinant protein replacement or monoclonal antibody modulation
Mechanism of Action	Recombinant protein replacement or monoclonal antibody modulation
Druggability	Low (0.36)
Clinical Stage	Phase II
Amino Acids	160 aa
Exons	5
Pathways	JAK-STAT pathway
UniProt ID	Q6FGW4
NCBI Gene ID	3586
GeneCards	IL10
Human Protein Atlas	IL10
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Crohn'S Disease, Hypertension
Known Drugs/Compounds	Viral Therapeutic Approach
Interactions	ACE, AHR, AKT, ALZHEIMER, AMYLOID, AND
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	588 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL10 — AlphaFold Q6FGW4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL10 — Interleukin 10

gene · 651 words

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Pathway Diagram

graph TD
    IL10["IL10"]
    IL10 -->|"activates"| osteoblastogenesis["osteoblastogenesis"]
    IL10 -->|"inhibits"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    IL10 -->|"inhibits"| Fibrosis["Fibrosis"]
    IL10 -->|"target for"| Ms["Ms"]
    IL10 -->|"target for"| Hepatitis["Hepatitis"]
    IL10 -->|"target for"| Carcinoma["Carcinoma"]
    IL10 -->|"target for"| Cancer["Cancer"]
    IL10 -->|"target for"| Als["Als"]
    IL10 -->|"target for"| Inflammation["Inflammation"]
    h_f9c6fa3f["h-f9c6fa3f"] -->|"target for"| IL10
    MICROGLIA["MICROGLIA"] -->|"expressed in"| IL10
    FGF20["FGF20"] -->|"target for"| IL10
    BRG1["BRG1"] -->|"target for"| IL10
    NRCAM["NRCAM"] -->|"target for"| IL10
    NOTCH2["NOTCH2"] -->|"target for"| IL10
    EP300["EP300"] -->|"target for"| IL10
    CTNNB1["CTNNB1"] -->|"target for"| IL10
    NEUROD1["NEUROD1"] -->|"target for"| IL10

Outgoing (363)

Target	Relation	Type	Str
Sphingolipid Metabolism	inhibits	pathway	0.95
Immune Cell Activation	inhibits	process	0.95
Cytokine Production	inhibits	process	0.95
M2 Microglia Phenotype	upregulates	phenotype	0.90
Neuroinflammation	treats	disease	0.90
SPHINGOLIPID METABOLISM	inhibits	entity	0.90
Neuroinflammation	inhibits	process	0.90
Microglia Polarization	modulates	process	0.90
Inflammatory Bowel Disease	protects_against	disease	0.90
very long chain ceramides	suppresses	compound	0.90
osteoblastogenesis	activates	pathway	0.90
Inflammation	inhibits	process	0.88
Dopaminergic Neuron Loss	protects_against	phenotype	0.85
innate immune cells	modulates	cell_type	0.85
Crohn's Disease	risk_factor_for	disease	0.85
Anti-Inflammatory Response	mediates	process	0.85
Immune Response	inhibits	process	0.85
Sphingolipid Metabolism	regulates	pathway	0.85
Crohn'S Disease	associated_with	disease	0.85
Atherosclerosis	inhibits	disease	0.80
Parkinson's Disease	treats	disease	0.80
MICROGLIA	regulates	entity	0.80
motor recovery	promotes	phenotype	0.80
MACROPHAGE	regulates	entity	0.80
Cancer	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
NEUROINFLAMMATION	inhibits	phenotype	0.72
Immune Response	involved_in	process	0.70
Atherosclerosis	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Als	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Infection	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65

Incoming (225)

Source	Relation	Type	Str
Mbdnf@Αitgev	upregulates	compound	0.90
h-f9c6fa3f	targets_gene	hypothesis	0.90
Lipid Nanoparticle	transports	compound	0.90
Betulinic Acid	upregulates	compound	0.90
Microglia	expressed_in	cell_type	0.90
Viral Therapeutic Approach	targets	drug	0.85
CD22 Blockade	upregulates	drug	0.85
Ginsenoside Ro	upregulates	compound	0.85
RU486	upregulates	drug	0.85
h-f9c6fa3f	targets	hypothesis	0.80
GINSENOSIDE_RO	upregulates	compound	0.80
mesenchymal stem cell	associated_with	cell_type	0.75
JUN	associated_with	gene	0.70
GENES	therapeutic_target	gene	0.70
TGFB1	associated_with	gene	0.70
TNF	associated_with	gene	0.70
GENES	associated_with	gene	0.70
NOS2	activates	gene	0.65
MICROGLIA	expressed_in	cell_type	0.64
CAT	expressed_in	gene	0.60
SORL1	associated_with	gene	0.60
CAT	biomarker_for	gene	0.60
CD200R1	binds_to	gene	0.60
ABCB1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
ATF3	targets	gene	0.60
AXIN2	targets	gene	0.60
CD44	targets	gene	0.60
CLDN1	targets	gene	0.60
DKK1	targets	gene	0.60
FGF18	targets	gene	0.60
FGF20	targets	gene	0.60
FZD7	targets	gene	0.60
AND	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
PROINFLAMMATORY CYTOKINES	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
TAU	expressed_in	gene	0.60
HDAC	activates	gene	0.60
MMP2	associated_with	gene	0.60
RAGE	therapeutic_target	gene	0.60
SYK	expressed_in	gene	0.60
TNF	activates	gene	0.60
NFL	activates	gene	0.60
BACE1	implicated_in	gene	0.60
BDNF	implicated_in	gene	0.60
HSPG2	implicated_in	gene	0.60
CDH1	therapeutic_target	gene	0.60
BAMBI	therapeutic_target	gene	0.60
MICRORNAS	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

IL10

Understanding Entity Pages

Summary

Wiki Pages (1)

IL10 — Interleukin 10

Pathway Diagram

Outgoing (363)

Incoming (225)

Targeting Hypotheses (0)

Mentioning Analyses (3)

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

Digital biomarkers and AI-driven early detection of neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (1)

Related Papers (0)

Debates (3)

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

What are the mechanisms underlying what are the mechanisms by which gut microbio