concept

FIBROBLAST

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FIBROBLAST: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1040Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FIBROBLAST
Related Pathways	AUTOPHAGY

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Fibroblast Growth Factor Signaling in Neurodegeneration

mechanism · 1987 words

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Pathway Diagram

graph TD
    FIBROBLAST["FIBROBLAST"]
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| FIBROBLAST
    MICROTUBULES["MICROTUBULES"] -->|"expressed in"| FIBROBLAST
    MAP6["MAP6"] -->|"expressed in"| FIBROBLAST
    TAU["TAU"] -->|"expressed in"| FIBROBLAST
    ROS["ROS"] -->|"expressed in"| FIBROBLAST
    BCL_2["BCL-2"] -->|"expressed in"| FIBROBLAST
    BAD["BAD"] -->|"expressed in"| FIBROBLAST
    HSPG2["HSPG2"] -->|"expressed in"| FIBROBLAST
    IGF1R["IGF1R"] -->|"expressed in"| FIBROBLAST
    DAG1["DAG1"] -->|"expressed in"| FIBROBLAST

Outgoing (56)

Target	Relation	Type	Str
myofibroblast	involved_in	cell_type	0.85
Myofibroblast	associated_with	cell_type	0.85
T CELLS	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
FIBROBLASTS	associated_with	concept	0.50
B CELLS	associated_with	concept	0.50
PDGF	activates	concept	0.50
FIBROBLASTS	interacts_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
GLUCOSE METABOLISM	activates	concept	0.50
Tgf-Β Signaling	activates	pathway	0.50
Rheumatoid Arthritis	protects_against	disease	0.50
Dentate Gyrus	expressed_in	brain_region	0.50
Basal Ganglia	expressed_in	brain_region	0.50
White Matter	expressed_in	brain_region	0.50
Corpus Callosum	expressed_in	brain_region	0.50
GLUT4	activates	concept	0.50
disease	interacts_with	disease	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Rheumatoid Arthritis	interacts_with	disease	0.50
Pain	interacts_with	disease	0.50
FIBROBLASTS	expressed_in	concept	0.50
NEURONS	interacts_with	concept	0.50
NEURONS	inhibits	concept	0.50
FIBROBLASTS	inhibits	concept	0.50
NEURONS	activates	concept	0.50
NEURONS	associated_with	concept	0.50
Cerebellum	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
Striatum	expressed_in	brain_region	0.50
Spinal Cord	expressed_in	brain_region	0.50
Substantia Nigra	expressed_in	brain_region	0.50
Proteins	interacts_with	protein	0.50
Sepsis	associated_with	disease	0.50
Pi3K/Akt	activates	pathway	0.50
Pulmonary Fibrosis	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
disease	activates	disease	0.50
FIBROBLASTS	activates	concept	0.50
MTOR SIGNALING	activates	concept	0.50
Rheumatoid Arthritis	associated_with	disease	0.50
Pancreatic Cancer	inhibits	disease	0.50
INSULIN	interacts_with	concept	0.50
EXTRACELLULAR MATRIX	interacts_with	concept	0.50
CHRONIC INFLAMMATION	interacts_with	concept	0.50
disease	expressed_in	disease	0.50
Spinocerebellar Ataxia	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50

Incoming (984)

Source	Relation	Type	Str
SESTRIN2	phosphorylates	gene	0.60
P62	activates	gene	0.60
SIRT3	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ULK1	activates	gene	0.60
KEAP1	activates	gene	0.60
FGF	interacts_with	gene	0.60
MITOCHONDRIA	causes	gene	0.60
NRF2	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
RNA	activates	gene	0.60
DEMENTIA	activates	gene	0.60
SPP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GRN	activates	gene	0.60
CTSB	activates	gene	0.60
C1QA	activates	gene	0.60
MICROTUBULES	regulates	gene	0.60
TAU	regulates	gene	0.60
MAP6	regulates	gene	0.60
APOE3	activates	gene	0.60
APOE	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
APOE4	activates	gene	0.60
LYSOSOME	regulates	gene	0.60
TRPML2	regulates	gene	0.60
TRPML1	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
MCOLN1	regulates	gene	0.60
JUN	regulates	gene	0.60
TRPML3	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
LYSOSOME	activates	gene	0.60
NRF1	therapeutic_target	gene	0.60
SIRT1	therapeutic_target	gene	0.60
DNM1L	therapeutic_target	gene	0.60
PRKAA1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
DRP1	therapeutic_target	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
OPA1	therapeutic_target	gene	0.60
RNA	associated_with	gene	0.60
ARF1	activates	gene	0.60
DNA	interacts_with	gene	0.60
FGF1	interacts_with	gene	0.60
ERK1/2	interacts_with	gene	0.60
FGF2	interacts_with	gene	0.60
C9ORF72	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YAP/TAZ Mechanosensing Cooperates with NF-κB to Amplify SPP1	0.492	neurodegeneration	How do perivascular cells specifically r
RAGE/STAT3/IL-6 Autocrine Loop Mediates Aβ-Induced SPP1 Upre	0.442	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FIBROBLAST in their description or question text

No additional research found