concept

FURIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FURIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FURIN
Key Genes/Proteins	ADAM10, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ARNTL
Related Diseases	Aging, Als, Alzheimer, Autoimmune
Related Pathways	Amyloid

Pathway Diagram

graph TD
    FURIN["FURIN"]
    style FURIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FURIN -->|"regulates"| LC3B([LC3B])
    FURIN -->|"causes"| cognitive_decline["cognitive decline"]
    FURIN -->|"causes"| neurodegeneration["neurodegeneration"]
    FURIN -->|"regulates"| autophagy["autophagy"]
    FURIN -->|"expressed in"| astrocytes["/astrocytes/"]
    FURIN -->|"target for"| Tumor["Tumor"]
    FURIN -->|"regulates"| Cancer["Cancer"]
    FURIN -->|"regulates"| Multiple_Sclerosis["Multiple Sclerosis"]
    FURIN -->|"regulates"| Alzheimer["Alzheimer"]
    FURIN -->|"regulates"| Autoimmune["Autoimmune"]
    MIRNAS([MIRNAS]) -->|"target for"| FURIN
    ADAM10([ADAM10]) -->|"causes"| FURIN
    EGFR([EGFR]) -->|"regulates"| FURIN
    CANCER([CANCER]) -->|"regulates"| FURIN
    GLIOBLASTOMA([GLIOBLASTOMA]) -->|"regulates"| FURIN
    AMYLOID([AMYLOID]) -->|"regulates"| FURIN
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FURIN
    AND([AND]) -->|"regulates"| FURIN
    BECN1([BECN1]) -->|"interacts"| FURIN
    MAP1LC3B([MAP1LC3B]) -->|"interacts"| FURIN

Outgoing (64)

Target	Relation	Type	Str
LC3B	regulates	gene	0.80
autophagy	regulates	process	0.70
astrocytes	expressed_in	cell_type	0.70
cognitive decline	causes	process	0.70
neurodegeneration	causes	process	0.70
Autoimmune	regulates	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ferroptosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Hypertension	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Bipolar	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
ALZHEIMER	regulates	gene	0.60
SREBF1	associated_with	gene	0.60
CAMKK2	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
ITGAV	associated_with	gene	0.60
PLIN3	inhibits	gene	0.60
Astrocyte	inhibits	cell_type	0.60
neurodegeneration	associated_with	disease	0.60
MAP1LC3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TYRO3	associated_with	gene	0.60
AND	causes	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
STAT3	regulates	gene	0.60
CD4	regulates	gene	0.60
Immune Response	regulates	pathway	0.60
GENES	regulates	gene	0.60
BACE1	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
GBM	regulates	gene	0.60

Incoming (39)

Source	Relation	Type	Str
GENES	associated_with	gene	0.70
ASTROCYTES	associated_with	gene	0.60
AND	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
RRAGA	associated_with	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
NFAT5	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
TRPC6	associated_with	gene	0.60
HTR6	associated_with	gene	0.60
LIPOPHAGY	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ADAM10	causes	gene	0.60
EGFR	regulates	gene	0.60
CANCER	regulates	gene	0.60
ITGAV	associated_with	gene	0.60
ATG5	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LAMP1	inhibits	gene	0.60
PLIN2	inhibits	gene	0.60
MAP1LC3	associated_with	gene	0.60
PLIN2	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
PLIN3	associated_with	gene	0.60
GLIOBLASTOMA	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
AND	regulates	gene	0.60
ASTROCYTES	inhibits	gene	0.60
MAP1LC3B	interacts_with	gene	0.50
BECN1	interacts_with	gene	0.50
LIPOPHAGY	inhibits	concept	0.50
Proteins	associated_with	protein	0.50
Neurodegeneration	associated_with	disease	0.50
Cognitive Decline	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FURIN in their description or question text

No additional research found