gene

AMYOTROPHIC LATERAL SCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYOTROPHIC LATERAL SCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5939Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

AMYOTROPHIC LATERAL SCLEROSIS is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1540 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AMYOTROPHIC LATERAL SCLEROSIS
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compounds	CRYPTOXANTHIN, RAPAMYCIN
Interactions	ACTB, AGING, AIF, ALS, ALS4, ALS-CAUSING MUTATIONS
KG Connections	2959 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Amyotrophic Lateral Sclerosis

redirect · 663 words

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Pathway Diagram

graph TD
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"associated"| Als["Als"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"associated"| Ms["Ms"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"regulates"| Alzheimer["Alzheimer"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"contributes to"| Als_1["Als"]
    OPTN["OPTN"] -->|"associated"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    P62["P62"] -->|"associated"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    MICROGLIA["MICROGLIA"] -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    style AMYOTROPHIC_LATERAL_SCLEROSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2621)

Target	Relation	Type	Str
Glaucoma	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
Inflammation	associated_with	disease	1.00
DEMENTIA	associated_with	gene	1.00
Parkinson	implicated_in	disease	1.00
MICROGLIA	activates	gene	1.00
Amyotrophic Lateral Sclerosis	implicated_in	disease	1.00
Als	implicated_in	disease	1.00
Parkinson	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Neurodegeneration	activates	disease	1.00
Stroke	associated_with	disease	1.00
Huntington	causes	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	1.00
Als	implicated_in	disease	1.00
Aging	associated_with	disease	1.00
Neurodegeneration	implicated_in	disease	1.00
Autophagy	therapeutic_target	pathway	1.00
Als	interacts_with	disease	1.00
Huntington	associated_with	disease	1.00
Neurodegeneration	implicated_in	disease	1.00
Alzheimer	activates	disease	1.00
DEMENTIA	causes	gene	1.00
Amyotrophic Lateral Sclerosis	interacts_with	disease	1.00
Parkinson	associated_with	disease	1.00
Alzheimer	implicated_in	disease	1.00
Alzheimer	associated_with	disease	1.00
Als	activates	disease	1.00
Als	associated_with	disease	1.00
Ataxia	associated_with	disease	1.00
Multiple Sclerosis	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	regulates	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
Dementia	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Neuroinflammation	associated_with	disease	1.00
Neurodegeneration	activates	disease	1.00
ALS	associated_with	gene	1.00
Alzheimer	regulates	disease	1.00
Parkinson	activates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Multiple Sclerosis	associated_with	disease	1.00
Dementia	causes	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Inflammation	regulates	disease	1.00
Neurodegeneration	causes	disease	1.00
Neurodegeneration	regulates	disease	1.00

Incoming (3318)

Source	Relation	Type	Str
entities-heat-shock-proteins	associated_with	wiki	0.00
entities-astrocytes	associated_with	wiki	0.00
entities-reactive-oxygen-species	associated_with	wiki	0.00
entities-atp7b-gene	associated_with	wiki	0.00
entities-glp1-receptor	associated_with	wiki	0.00
entities-microtubules	associated_with	wiki	0.00
entities-mitochondrial-dynamics	associated_with	wiki	0.00
entities-hepcidin	associated_with	wiki	0.00
ALS	activates	gene	1.00
ALS	regulates	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
C9ORF72	associated_with	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
GENES	associated_with	gene	1.00
OPTN	associated_with	gene	1.00
ASTROCYTES	activates	gene	1.00
OPTN	associated_with	gene	1.00
DNA	therapeutic_target	gene	1.00
ALZHEIMER	associated_with	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
C9ORF72	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
PARKINSON'S DISEASE	activates	gene	1.00
ALS	regulates	gene	1.00
Parkinson	associated_with	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
Huntington	associated_with	disease	1.00
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	1.00
ALS	associated_with	gene	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
DNA	therapeutic_target	gene	1.00
ALS	interacts_with	gene	1.00
Als	causes	disease	1.00
NEURODEGENERATION	regulates	gene	1.00
SOD1	causes	gene	1.00
NEURODEGENERATIVE DISORDERS	part_of	gene	1.00
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	1.00
MICROGLIA	activates	gene	1.00
STROKE	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATION	activates	gene	1.00
NEURON	associated_with	gene	1.00
MOTOR NEURONS	causes	gene	1.00
Als	activates	disease	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity