gene 1,515 words KG: WIPI2
Contents

WIPI2 - WD Repeat Domain, Phosphoinositide Interacting 2

🧬 Gene Info
Gene SymbolWIPI2
AliasesPage for WIPI2, WD repeat domain, phosphoinositide-interacting protein 2
Chromosome7q36.3
Protein FamilyPROPPIN family (beta-propeller, PI3P binding)
Functionencodes a 445-amino acid protein with a molecular mass of approximately 46 kDa.
Molecular Weight46 kDa
Amino Acids466 aa
Exons16
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt ID[Q9Y5P8](https://www.uniprot.org/uniprot/Q9Y5P8)
Ensembl IDENSG00000157911
GeneCardsWIPI2
Human Protein AtlasWIPI2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Carcinoma, Dementia
Known Drugs/Compoundsrapamycin
InteractionsACAT1, Actin, ALS4, AMPK, amyotrophic lateral sclerosis, AND
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (12)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94
APOE-Dependent Autophagy Restoration
Score: 0.86
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Positioning Dynamics Modulation
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62

Related Analyses (7)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (16)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ACTB Gene
gene · KG edge: associated_with
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

KAT8 associated_with WIPI2
OPTN associated_with WIPI2
ULK1 associated_with WIPI2
CALCOCO2 associated_with WIPI2
HSPA8 associated_with WIPI2
STX17 associated_with WIPI2
SQSTM1 associated_with WIPI2
RB1CC1 associated_with WIPI2
SIRT1 associated_with WIPI2
LC3 associated_with WIPI2

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