protein 1,333 words KG: WIPI2
Contents

WIPI2 Protein

🔬 Protein Info
Gene SymbolWIPI2
AliasesPage for WIPI2, WD repeat domain, phosphoinositide-interacting protein 2
Chromosome7q36.3
Protein FamilyPROPPIN family (beta-propeller, PI3P binding)
Functionencodes a 445-amino acid protein with a molecular mass of approximately 46 kDa.
Subcellular Localizations, with WIPI2b showing predominant association with the Golgi apparatus and WIPI2a being more evenly distributed in the
Molecular Weight46 kDa
Amino Acids466 aa
Exons16
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt ID[Q9Y5P8](https://www.uniprot.org/uniprot/Q9Y5P8)
Ensembl IDENSG00000157911
GeneCardsWIPI2
Human Protein AtlasWIPI2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Carcinoma, Dementia
Known Drugs/Compoundsrapamycin
InteractionsACAT1, Actin, ALS4, AMPK, amyotrophic lateral sclerosis, AND
KG Connections439 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (9)

APOE-Dependent Autophagy Restoration
Score: 0.88
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Positioning Dynamics Modulation
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ACTB Gene
gene · KG edge: activates
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: activates

Knowledge Graph (12 edges)

KAT8 associated_with WIPI2
OPTN associated_with WIPI2
ULK1 associated_with WIPI2
CALCOCO2 associated_with WIPI2
HSPA8 associated_with WIPI2
STX17 associated_with WIPI2
SQSTM1 associated_with WIPI2
RB1CC1 associated_with WIPI2
SIRT1 associated_with WIPI2
LC3 associated_with WIPI2

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