protein

BRCA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRCA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

455Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BRCA1 is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Anxiety. Connected to 316 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BRCA1
Full Name	BRCA1 DNA Repair Associated
Chromosome	17q21
Function	BRCA1 is a key component of the DNA damage response machinery
Primary Expression	most tissues with high expression in: - Breast and ovarian epithelium - Testis - Brain (neurons and glia) - Proliferating cells
Pathways	Apoptosis, Autophagy, Cell Cycle, Dna Repair, Immune Response
UniProt ID	P38398
NCBI Gene ID	672
Ensembl ID	ENSG00000012048
OMIM	113705
GeneCards	BRCA1
Human Protein Atlas	BRCA1
Associated Diseases	Als, Breast Cancer, Cancer, Carcinoma, Melanoma
Interactions	ABHD12, Actin, AND, APOPTOSIS, ARC, ATG3
KG Connections	455 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BRCA1 — AlphaFold P38398 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BRCA1["BRCA1"]
    BRCA1 -.biomarker for.-> Cancer["Cancer"]
    BRCA1 -.biomarker for.-> Als["Als"]
    BRCA1 -.biomarker for.-> Ms["Ms"]
    BRCA1 -->|"inhibits"| Tumor["Tumor"]
    BRCA1 -->|"regulates"| Aging["Aging"]
    SOX2["SOX2"] -.biomarker for.-> BRCA1
    GAIN["GAIN"] -.biomarker for.-> BRCA1
    BCL_2["BCL-2"] -.biomarker for.-> BRCA1
    OVERVIEW["OVERVIEW"] -.biomarker for.-> BRCA1
    AGING["AGING"] -->|"regulates"| BRCA1
    FOS["FOS"] -->|"target for"| BRCA1
    HIPPO["HIPPO"] -->|"expressed in"| BRCA1
    SP1["SP1"] -->|"target for"| BRCA1
    MIR_9_5P["MIR-9-5P"] -->|"expressed in"| BRCA1
    SIRT1["SIRT1"] -->|"target for"| BRCA1

Outgoing (300)

Target	Relation	Type	Str
Cancer	associated_with	disease	1.00
CANCER	associated_with	gene	1.00
GENES	associated_with	gene	1.00
Als	expressed_in	disease	0.95
BRCA2	associated_with	gene	0.90
Als	therapeutic_target	disease	0.85
Als	regulates	disease	0.85
Cancer	therapeutic_target	disease	0.85
Tumor	activates	disease	0.85
Cancer	regulates	disease	0.85
Cancer	inhibits	disease	0.85
Aging	therapeutic_target	disease	0.85
Tumor	therapeutic_target	disease	0.85
Cancer	activates	disease	0.85
Carcinoma	activates	disease	0.75
Als	activates	disease	0.75
Tumor	inhibits	disease	0.75
Als	biomarker_for	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Breast Cancer	associated_with	disease	0.75
ubiquitin-proteasome	participates_in	pathway	0.70
PARP1	inhibits	gene	0.70
CANCER	activates	gene	0.70
GENES	expressed_in	gene	0.70
Autophagy	regulates	pathway	0.70
Autophagy	activates	pathway	0.70
P62	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
Ferroptosis	activates	pathway	0.70
CANCER	therapeutic_target	gene	0.70
Ovarian Cancer	causes	disease	0.65
Renal Cell Carcinoma	activates	disease	0.65
Diabetes	regulates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Tumor	regulates	disease	0.65
Ovarian Cancer	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
Ataxia	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Breast Cancer	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Longevity	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	regulates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	regulates	disease	0.65

Incoming (155)

Source	Relation	Type	Str
PTEN	associated_with	gene	0.90
AUTOPHAGY	activates	gene	0.70
CANCER	inhibits	gene	0.70
BAP1	interacts_with	gene	0.70
ABHD12	interacts_with	protein	0.70
TP53	associated_with	gene	0.70
PARP1	inhibits	gene	0.70
CANCER	regulates	gene	0.70
CDKN2A	associated_with	gene	0.70
CANCER	activates	gene	0.60
P53	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	therapeutic_target	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	interacts_with	gene	0.60
KRAS	associated_with	gene	0.60
ROS	regulates	gene	0.60
ENDOSOME	activates	gene	0.60
APOPTOSIS	implicated_in	gene	0.60
AND	interacts_with	gene	0.60
AND	associated_with	gene	0.60
INS	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
ROS	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
DNA	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
PYROPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
UBIQUITIN	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
BAP1	inhibits	gene	0.60
SIRT6	regulates	gene	0.60
PARP1	regulates	gene	0.60
HNRNPA1	activates	gene	0.60
MYC	regulates	gene	0.60
DDX5	activates	gene	0.60
PIN1	regulates	gene	0.60
TRIM32	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
CD8	activates	gene	0.60
NBR1	interacts_with	gene	0.60
MAVS	associated_with	gene	0.60
RNF5	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BRCA1 in their description or question text

No additional research found