gene

TOMM70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TOMM70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

20Outgoing

19Incoming

0Experiments

0Debates

Summary

TOMM70 is a critical receptor component of the mitochondrial outer membrane translocase complex, essential for protein import and mitochondrial function in neurodegeneration

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🧬 Gene Info

Gene Symbol	TOMM70
Protein Family	Translocase of outer mitochondrial membrane (TOM) complex
Protein Type	Receptor
Function	is a critical component of the mitochondrial outer membrane translocase complex (TOM), responsible for importing nearly all nuclear-encoded mitochondrial proteins[@nature2010].
Primary Expression	Mitochondrial outer membrane
Subcellular Localization	Mitochondrial outer membrane
Molecular Weight	67 kDa
Amino Acids	627 aa
Pathways	Autophagy, Mitophagy
UniProt ID	Q9NS69
GeneCards	TOMM70
Human Protein Atlas	TOMM70
Associated Diseases	Alzheimer
Known Drugs/Compounds	Spautin-1
Interactions	ALZHEIMER, ALZHEIMER DISEASE, AND, AUTOPHAGY, BECN1, LYSOSOME
KG Connections	39 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: TOMM70 — AlphaFold Q9NS69 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TOMM70

gene · 1476 words

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TOMM70 Protein

protein · 616 words

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Pathway Diagram

graph TD
    TOMM70["TOMM70"]
    Alzheimer{"Alzheimer"}
    TOMM70 -->|"activates"| Alzheimer
    PIK3C3["PIK3C3"]
    TOMM70 -->|"activates"| PIK3C3
    PINK1["PINK1"]
    TOMM70 -->|"interacts with"| PINK1
    TOMM20["TOMM20"]
    TOMM70 -->|"interacts with"| TOMM20
    AUTOPHAGY["AUTOPHAGY"]
    TOMM70 -->|"activates"| AUTOPHAGY
    Mitophagy(["Mitophagy"])
    TOMM70 -->|"activates"| Mitophagy
    Autophagy(["Autophagy"])
    TOMM70 -->|"activates"| Autophagy
    neurodegeneration["neurodegeneration"]
    TOMM70 -->|"implicated in"| neurodegeneration
    Spautin_1["Spautin-1"]
    Spautin_1 -->|"binds"| TOMM70
    PRKN["PRKN"]
    PRKN -->|"activates"| TOMM70
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"]
    ALZHEIMER_DISEASE -->|"activates"| TOMM70
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| TOMM70
    AND["AND"]
    AND -->|"interacts with"| TOMM70
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"activates"| TOMM70
    MITOCHONDRIA["MITOCHONDRIA"]
    MITOCHONDRIA -->|"interacts with"| TOMM70
    PARL["PARL"]
    PARL -->|"interacts with"| TOMM70
    BECN1["BECN1"]
    BECN1 -->|"activates"| TOMM70
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| TOMM70
    PARL -->|"activates"| TOMM70
    PINK1 -->|"activates"| TOMM70
    style TOMM70 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Mitophagy	activates	pathway	0.60
Autophagy	activates	pathway	0.60
MITOCHONDRIA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MITOPHAGY	activates	gene	0.60
PRKN	activates	gene	0.60
PARL	interacts_with	gene	0.60
BECN1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Neuron	activates	cell_type	0.60
ALZHEIMER DISEASE	activates	gene	0.60
Ubiquitin	activates	protein	0.60
Alzheimer	associated_with	disease	0.60
PIK3C3	activates	gene	0.60
PINK1	interacts_with	gene	0.60
TOMM20	interacts_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
PARL	activates	protein	0.50
VPS34	co_expressed_with	protein	0.50

Incoming (19)

Source	Relation	Type	Str
Spautin-1	binds	compound	0.85
PARL	interacts_with	gene	0.60
BECN1	activates	gene	0.60
PRKN	activates	gene	0.60
PARL	activates	entity	0.60
PINK1	activates	entity	0.60
TOMM20	activates	entity	0.60
PIK3C3	activates	gene	0.60
PINK1	interacts_with	gene	0.60
TOMM20	interacts_with	gene	0.60
ALZHEIMER	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIA	interacts_with	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
PRKN	co_expressed_with	gene	0.50
MITOCHONDRIA	activates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TOMM70 in their description or question text

No additional research found