gene

ATP6V0D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP6V0D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

26Outgoing

8Incoming

0Experiments

0Debates

Summary

ATP6V0D1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, implicated in. Associated with Bacterial Infection, Infection, Inflammation. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATP6V0D1
Full Name	ATPase H+ Transporting V0 Subunit D1
Chromosome	16p13.3
Protein Type	V-ATPase subunit (V0 domain)
Function	encodes a critical subunit of the vacuolar-type H+-ATPase (V-ATPase), a multisubunit proton pump essential for acidification of intracellular compartments throughout the cell.
Primary Expression	Brain, Liver, Kidney, Ubiquitous
Gene Type	Protein coding
Pathways	Autophagy, Inflammasome
UniProt ID	P61421
NCBI Gene ID	9114
Ensembl ID	ENSG00000159720
OMIM	618171
GeneCards	ATP6V0D1
Human Protein Atlas	ATP6V0D1
Associated Diseases	Melanoma, Tumor
Interactions	ACTB, ATG14, ATG16L1, AUTOPHAGY, INFLAMMATION, LYSOSOME
KG Connections	34 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATP6V0D1 — AlphaFold P61421 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATP6V0D1 — ATPase H+ Transporting V0 Subunit D1

gene · 2330 words

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Pathway Diagram

graph TD
    ATP6V0D1["ATP6V0D1
(V-ATPase subunit)"] -->|"activates"| AUTOPHAGY["Autophagy"]
    ATP6V0D1 -->|"activates"| LYSOSOME["Lysosome"]
    ATP6V0D1 -->|"activates"| ATG14["ATG14"]
    ATP6V0D1 -->|"activates"| ATG16L1["ATG16L1"]
    
    AUTOPHAGY -->|"requires"| LC3["LC3"]
    AUTOPHAGY -->|"requires"| P62["P62/SQSTM1"]
    ATG14 -->|"forms complex"| LC3
    ATG16L1 -->|"promotes"| AUTOPHAGY
    
    LYSOSOME -->|"associates with"| LAMP1["LAMP1"]
    LYSOSOME -->|"fuses via"| SNAP29["SNAP29"]
    LYSOSOME -->|"fuses via"| STX17["STX17"]
    
    ATP6V0D1 -->|"activates"| Inflammasome["Inflammasome Pathway"]
    Inflammasome -->|"activates"| NLRP3["NLRP3"]
    Inflammasome -->|"activates"| PYCARD["ASC/PYCARD"]
    NLRP3 -->|"activates"| CASP1["Caspase-1"]
    CASP1 -->|"processes"| IL1B["IL-1beta"]
    
    ATP6V0D1 -->|"promotes"| Inflammation["Neuroinflammation"]
    Inflammation -->|"releases"| TNF["TNF-alpha"]
    Inflammation -->|"releases"| IL6["IL-6"]

    style ATP6V0D1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style AUTOPHAGY fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style LYSOSOME fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style ATG14 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style ATG16L1 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style LC3 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style P62 fill:#4a1a6b,stroke:#9c27b0,stroke-width:2px
    style NLRP3 fill:#ef5350,stroke:#f44336,stroke-width:2px
    style Inflammasome fill:#ef5350,stroke:#f44336,stroke-width:2px
    style Inflammation fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style IL1B fill:#ef5350,stroke:#f44336,stroke-width:2px
    style TNF fill:#ef5350,stroke:#f44336,stroke-width:2px

Outgoing (26)

Target	Relation	Type	Str
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Tumor	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
PYCARD	associated_with	gene	0.60
P62	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
ATG14	activates	gene	0.60
CASP1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
ATG16L1	activates	gene	0.60
CSF1	associated_with	gene	0.60
STX17	associated_with	gene	0.60
TOMM20	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
LYSOSOME	activates	gene	0.60
Toll-Like Receptor	associated_with	pathway	0.60
Inflammasome	activates	pathway	0.60
NLRP3	associated_with	gene	0.60
Autophagy	activates	pathway	0.60
ACTB	activates	gene	0.60
IL6	associated_with	gene	0.60
LC3	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60

Incoming (8)

Source	Relation	Type	Str
ASC	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
TLR	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity