gene

STUB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STUB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

245Connections

4Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

STUB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 138 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STUB1
Full Name	STIP1 Homology And U-Box Containing Protein 1
Aliases	CHIP
Chromosome	16p13.3
Protein Family	U-box E3 ubiquitin ligase family
Function	encodes a ubiquitin ligase and cochaperone that plays critical roles in protein quality control
Molecular Weight	34.6 kDa
Amino Acids	305 aa
Pathways	Chaperone, Proteasome, Ubiquitin-Proteasome
UniProt ID	Q9UNE7
NCBI Gene ID	10273
Ensembl ID	ENSG00000120539
OMIM	607207
GeneCards	STUB1
Human Protein Atlas	STUB1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, dementia, frontotemporal, Huntington
Known Drugs/Compounds	rapamycin
Interactions	amyotrophic lateral sclerosis, AND, AR, ATG, ATG10, ATG12
SciDEX Hypotheses	Kinetic Threshold Model of Chaperone-CHIP Coupling HSP70 recognition of exposed β-sheet segments trig Kinetic Threshold Model Predicts CHIP-Mediated Cle (+1 more)
KG Connections	245 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: STUB1 — AlphaFold Q9UNE7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STUB1["STUB1"]
    STUB1 -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    STUB1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    STUB1 -->|"activates"| Carcinoma["Carcinoma"]
    STUB1 -->|"activates"| Ms["Ms"]
    STUB1 -->|"activates"| ATG10["ATG10"]
    STUB1 -->|"activates"| CALCINEURIN["CALCINEURIN"]
    STUB1 -->|"activates"| ATG12["ATG12"]
    STUB1 -->|"interacts"| BAG3["BAG3"]
    STUB1 -->|"interacts"| HSPB8["HSPB8"]
    STUB1 -->|"activates"| Autophagy["Autophagy"]
    CALCINEURIN -->|"activates"| STUB1
    ATG12 -->|"activates"| STUB1
    GENES["GENES"] -->|"activates"| STUB1
    DNA["DNA"] -->|"activates"| STUB1
    SNAP29["SNAP29"] -->|"activates"| STUB1
    STX17["STX17"] -->|"activates"| STUB1
    DRAM1["DRAM1"] -->|"regulates"| STUB1
    HSPB8 -->|"interacts"| STUB1
    BAG3 -->|"interacts"| STUB1
    VAMP8["VAMP8"] -->|"regulates"| STUB1

Outgoing (125)

Target	Relation	Type	Str
Hsp70-bound tau	ubiquitinates	mechanism	0.90
ubiquitin_proteasome	participates_in	pathway	0.70
tau	targets	protein	0.70
tau protein	modulates	protein	0.70
Ms	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
LGALS3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
P62	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TARDBP	activates	entity	0.60
TFEB	activates	entity	0.60
TPP1	activates	entity	0.60
TREH	activates	entity	0.60
Neural Progenitor	associated_with	cell_type	0.60
VCP	regulates	gene	0.60
Chaperone	associated_with	pathway	0.60
Tdp-43	associated_with	pathway	0.60
Sod1	associated_with	pathway	0.60
AND	inhibits	gene	0.60
SQSTM1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
ALS	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
dementia	associated_with	disease	0.60
TAR	activates	gene	0.60
TAK1	interacts_with	gene	0.60
Stem Cell	associated_with	pathway	0.60
GENES	inhibits	gene	0.60
Autophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Chaperone	regulates	pathway	0.60
Proteasome	regulates	pathway	0.60
Parkinson's disease	activates	disease	0.60
Huntington's disease	activates	disease	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60

Incoming (120)

Source	Relation	Type	Str
PINK1	interacts_with	gene	0.80
HSPA1A	protein_interaction	gene	0.70
TRAF6	interacts_with	gene	0.60
TREH	associated_with	gene	0.60
AR	activates	gene	0.60
SQSTM1	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
HSC70	regulates	gene	0.60
RNA	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
HSPB8	interacts_with	gene	0.60
BAG3	interacts_with	gene	0.60
TFEB	inhibits	gene	0.60
GAPDH	associated_with	gene	0.60
TDP-43	associated_with	gene	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
ALS	activates	entity	0.60
STIP1	associated_with	gene	0.60
HSPA8	regulates	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
VAMP8	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
ATG10	activates	gene	0.60
BECN1	associated_with	gene	0.60
HSPA1A	regulates	gene	0.60
BAG3	regulates	gene	0.60
SPG7	causes	gene	0.60
DNA	activates	gene	0.60
TLR	interacts_with	gene	0.60
NF-ΚB	activates	gene	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
PPP3	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HSP70 recognition of exposed β-sheet segments triggers CHIP-	0.380	protein-biochemistry	Do chaperones selectively recognize path
Kinetic Threshold Model Predicts CHIP-Mediated Clearance Req	0.380	protein-folding	Can chaperone enhancement approaches ove
Kinetic Threshold Model of Chaperone-CHIP Coupling: ATP Cycl	0.380	protein-folding	Can chaperone enhancement approaches ove
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.380	protein-biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

drug discovery | 2026-04-09 | 7 hypotheses Top: 0.455

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

protein folding | 2026-04-06 | 13 hypotheses Top: 0.815

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

closed · Rounds: 4 · Score: 0.86 · 2026-04-10

Related Research

Hypotheses and analyses mentioning STUB1 in their description or question text

No additional research found

STUB1

Understanding Entity Pages

Summary

Wiki Pages (3)

STUB1/CHIP Protein

CHIP Protein (STUB1)

STUB1 — CHIP

Pathway Diagram

Outgoing (125)

Incoming (120)

Targeting Hypotheses (4)

Mentioning Analyses (2)

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

Experiments (0)

Related Papers (0)

Debates (2)

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

What are the minimal structural requirements for HSP70/HSP90 inhibitors to achie

Related Research