gene

STIP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

193Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

STIP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STIP1
Full Name	STIP1 / HOP
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	62.5 kDa
Amino Acids	548 aa
Pathways	Apoptosis, Chaperone, Tdp-43, autophagy pathway, oxidative stress response
UniProt ID	Q9YLS8
GeneCards	STIP1
Human Protein Atlas	STIP1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	amyotrophic lateral sclerosis, AND, APOPTOSIS, AQP4, AQUAPORIN-4, AR
KG Connections	193 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: STIP1 — AlphaFold Q9YLS8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

STIP1 Gene

gene · 647 words

→

STIP1 Protein

protein · 697 words

→

Pathway Diagram

graph TD
    STIP1["STIP1"]
    STIP1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    STIP1 -->|"activates"| Lymphoma["Lymphoma"]
    STIP1 -->|"activates"| Als["Als"]
    STIP1 -->|"activates"| Ms["Ms"]
    STIP1 -->|"activates"| CALCINEURIN["CALCINEURIN"]
    STIP1 -->|"activates"| ATG12["ATG12"]
    STIP1 -->|"activates"| ATG10["ATG10"]
    STIP1 -->|"activates"| APOPTOSIS["APOPTOSIS"]
    STIP1 -->|"activates"| KEAP1["KEAP1"]
    STIP1 -->|"activates"| HO_1["HO-1"]
    GENES["GENES"] -->|"activates"| STIP1
    CALCINEURIN -->|"activates"| STIP1
    ATG12 -->|"activates"| STIP1
    ATG10 -->|"activates"| STIP1
    BCL2["BCL2"] -->|"activates"| STIP1
    AQP4["AQP4"] -->|"activates"| STIP1
    GNAI2["GNAI2"] -->|"activates"| STIP1
    TREHALOSE["TREHALOSE"] -->|"activates"| STIP1

Outgoing (118)

Target	Relation	Type	Str
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Lymphoma	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	activates	gene	0.60
LAMP1	associated_with	gene	0.60
KEAP1	activates	gene	0.60
NRF2	activates	gene	0.60
TFEB	associated_with	gene	0.60
AQP4	activates	gene	0.60
BCL2	activates	gene	0.60
GNAI2	activates	gene	0.60
STUB1	activates	entity	0.60
TARDBP	activates	entity	0.60
TFEB	activates	entity	0.60
TPP1	activates	entity	0.60
TREH	activates	entity	0.60
P62	associated_with	gene	0.60
Neural Progenitor	associated_with	cell_type	0.60
APOPTOSIS	activates	gene	0.60
HO-1	activates	gene	0.60

Incoming (75)

Source	Relation	Type	Str
BCL2	activates	gene	0.60
AQP4	activates	gene	0.60
GNAI2	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
rapamycin	targets	drug	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
TREH	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
AR	activates	gene	0.60
AND	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
AQUAPORIN-4	activates	gene	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
PPP3	associated_with	gene	0.60
RNA	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BAG3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
GLA	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
ATG10	activates	gene	0.60
MCOLN1	associated_with	gene	0.60
KEAP1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STIP1 in their description or question text

No additional research found