gene

POLG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POLG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

264Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

POLG is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Aging, Als. Connected to 147 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	POLG
Full Name	DNA Polymerase Subunit Gamma
Chromosome	15q25
Protein Type	Tissues Affected
Function	POLG is the catalytic engine of the mitochondrial DNA replication machinery, one of the essential components of the mtDNA replisome that includes the helicase TWNK (Twinkle), the single-stranded DNA-b
Molecular Weight	140 kDa
Amino Acids	1239 aa
Pathways	Mitophagy
UniProt ID	Q9UQF2
NCBI Gene ID	5428
Ensembl ID	ENSG00000140521
OMIM	174763
GeneCards	POLG
Human Protein Atlas	POLG
Associated Diseases	Aging, Als, Alzheimer's disease, Ataxia, Bipolar
Interactions	ALOX, AND, APOPTOSIS, App, ATG, BAX
KG Connections	264 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: POLG — AlphaFold Q9UQF2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    POLG["POLG
Mitochondrial DNA
Polymerase gamma"]
    MTDNA["MTDNA
Mitochondrial DNA
Replication"]
    DNA_REP["DNA Repair
 and Maintenance"]
    MITO_DYSFUNC["Mitochondrial
Dysfunction"]
    AUTOPHAGY["Autophagy
Pathway"]
    FERROPTOSIS["Ferroptosis
Pathway"]
    ATM["ATM
DNA Damage
Response"]
    STING1["STING1
Innate Immunity
Signaling"]
    SLC7A11["SLC7A11
Cystine/Glutamate
Antiporter"]
    CIRCADIAN["Circadian Rhythm
Regulation"]
    PARKINSON["Parkinson's
Disease"]
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    NEURODEGENERATION["Neurodegeneration
Outcomes"]
    OXIDATIVE["Oxidative Stress
 and Cell Death"]

    POLG -->|"replicates"| MTDNA
    POLG -->|"maintains"| DNA_REP
    MTDNA -->|"dysfunction"| MITO_DYSFUNC
    MITO_DYSFUNC -->|"triggers"| OXIDATIVE
    POLG -->|"activates"| FERROPTOSIS
    POLG -->|"associated with"| AUTOPHAGY
    POLG -->|"interacts with"| ATM
    POLG -->|"signals through"| STING1
    POLG -->|"regulates"| SLC7A11
    POLG -->|"influences"| CIRCADIAN
    OXIDATIVE -->|"leads to"| PARKINSON
    OXIDATIVE -->|"leads to"| ALS
    OXIDATIVE -->|"leads to"| MS
    FERROPTOSIS -->|"contributes to"| NEURODEGENERATION
    PARKINSON -->|"part of"| NEURODEGENERATION
    ALS -->|"part of"| NEURODEGENERATION
    MS -->|"part of"| NEURODEGENERATION

    style POLG fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style ATM fill:#4a1a6b
    style STING1 fill:#4a1a6b
    style SLC7A11 fill:#4a1a6b
    style CIRCADIAN fill:#4a1a6b
    style FERROPTOSIS fill:#ef5350
    style MITO_DYSFUNC fill:#ef5350
    style OXIDATIVE fill:#ef5350
    style PARKINSON fill:#5d4400
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style NEURODEGENERATION fill:#5d4400

Outgoing (157)

Target	Relation	Type	Str
mtDNA	involved_in	compound	0.85
mtDNA	regulates	compound	0.80
Intestinal Barrier Disruption	causes	phenotype	0.80
Als	associated_with	disease	0.75
Als	activates	disease	0.75
Ataxia	associated_with	disease	0.75
DNA	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
Mood Disorder	associated_with	disease	0.70
OXIDATIVE STRESS	activates	gene	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
DNA	associated_with	gene	0.70
parkinsonism	associated_with	disease	0.70
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.70
Neurodegeneration	activates	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
ALS	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neuropathy	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Aging	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Apoptosis	activates	pathway	0.60
Oxidative Phosphorylation	activates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Glycolysis	activates	pathway	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
AGING	associated_with	gene	0.60
AND	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
RNF216	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
STING1	activates	entity	0.60
TFAM	activates	entity	0.60
TMEM173	activates	entity	0.60
NCOA4	associated_with	gene	0.60
DAO	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60

Incoming (107)

Source	Relation	Type	Str
ROS	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CANCER	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
MAP1LC3B	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
TMEM173	associated_with	gene	0.60
FANCD2	associated_with	gene	0.60
STING1	associated_with	gene	0.60
TFAM	associated_with	gene	0.60
BAX	activates	gene	0.60
POLG2	associated_with	gene	0.60
SLC25A4	associated_with	gene	0.60
MFN2	associated_with	gene	0.60
TYMP	associated_with	gene	0.60
RRM2B	associated_with	gene	0.60
TK2	associated_with	gene	0.60
SUCLA2	associated_with	gene	0.60
SUCLG1	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
DEPRESSION	associated_with	gene	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
AND	contributes_to	gene	0.60
AND	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
MTDNA	expressed_in	gene	0.60
AGING	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
TRPM2	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
PINK1	therapeutic_target	gene	0.60
PARKIN	associated_with	gene	0.60
LRRK2	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALOX	activates	gene	0.60
ATG	activates	gene	0.60
DNA	activates	gene	0.60
HTR2A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning POLG in their description or question text

No additional research found