concept

TAU PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

300Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TAU PROTEIN
Key Genes/Proteins	NFKB, VPS35
Related Diseases	Alzheimer's Disease, Tauopathies

Pathway Diagram

graph TD
    TAU_PROTEIN["TAU PROTEIN"]
    style TAU_PROTEIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    TAU_PROTEIN -.->|"biomarker for"| Alzheimer_s_Disease["Alzheimer's Disease"]
    TAU_PROTEIN -.->|"biomarker for"| Tauopathies["Tauopathies"]
    TAU_PROTEIN -->|"involved_in"| Hyperphosphorylation["Hyperphosphorylation"]
    TAU_PROTEIN -->|"expressed in"| Retina["/Retina/"]
    TAU_PROTEIN -->|"causes"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    TAU_PROTEIN -->|"interacts"| NFKB([NFKB])
    TAU_PROTEIN -->|"causes"| neuronal_damage["neuronal damage"]
    TAU_PROTEIN -->|"activates"| Reactive_oxygen_species["Reactive oxygen species"]
    Alzheimer_s_Disease -.->|"biomarker for"| TAU_PROTEIN
    Cerebrospinal_Fluid["Cerebrospinal Fluid"] -->|"component_of"| TAU_PROTEIN
    Post_translational_Modificatio["Post-translational Modifications"] -->|"regulates"| TAU_PROTEIN
    MAPT([MAPT]) -->|"encodes"| TAU_PROTEIN
    NBR1([NBR1]) -->|"interacts"| TAU_PROTEIN
    CBD{"CBD"} -->|"regulates"| TAU_PROTEIN
    Cannabidiol{"Cannabidiol"} -.->|"inhibits"| TAU_PROTEIN
    FBXW7([FBXW7]) -->|"regulates"| TAU_PROTEIN

Outgoing (125)

Target	Relation	Type	Str
Hyperphosphorylation	involved_in	process	0.95
Tauopathies	involved_in	disease	0.95
Tauopathies	biomarker_for	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.95
Alzheimer'S Disease	contributes_to	disease	0.95
Neurofibrillary Tangles	causes	entity	0.95
Axonal Transport	regulates	process	0.92
Axonal Structure	regulates	structure	0.92
Retina	expressed_in	cell_type	0.90
Alzheimer'S Disease	causes	disease	0.90
tau protein hyperphosphorylation	involved_in	process	0.90
cytoskeletal remodeling	associated_with	process	0.90
CSF tau assays	biomarker_for	process	0.88
Alzheimer's Disease	causes	disease	0.80
NFKB	interacts_with	protein	0.80
cognitive dysfunction	associated_with	process	0.70
RNA	interacts_with	process	0.70
RNA-binding proteins	interacts_with	protein	0.70
Alzheimer's disease	associated_with	disease	0.70
trans-synaptic propagation	associated_with	process	0.70
Oxidative Stress	interacts_with	process	0.70
neurofibrillary tangles	promotes	process	0.70
fibrillar structures	promotes	process	0.70
Alzheimer's disease	associated_with	disease	0.70
Reactive oxygen species	activates	process	0.70
neurodegenerative diseases	associated_with	disease	0.70
neuronal damage	causes	process	0.70
Alzheimer's disease	causes	disease	0.70
Parkinson's Disease	implicated_in	disease	0.65
Alzheimer	therapeutic_target	disease	0.60
Dementia	stabilizes	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Frontotemporal Dementia	stabilizes	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Alzheimer	protects_against	disease	0.60
Neurodegeneration	encodes	disease	0.60
Aging	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Alzheimer	expressed_in	disease	0.60
Aging	biomarker_for	disease	0.60
Tauopathy	stabilizes	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Tauopathy	associated_with	disease	0.60
Als	encodes	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Diabetes	expressed_in	disease	0.60
Als	activates	disease	0.60

Incoming (175)

Source	Relation	Type	Str
MAPT	associated_with	gene	0.95
MAPT	associated_with	gene	0.95
Hyperphosphorylation	modulates	process	0.90
VPS35	regulates	protein	0.85
MTOR	regulates	gene	0.80
MTOR	enhances	gene	0.80
Post-translational Modifications	regulates	process	0.80
MAPT	encodes	gene	0.70
Alzheimer's disease	associated_with	disease	0.70
NBR1	interacts_with	protein	0.70
Cannabidiol	inhibits	drug	0.70
CBD	regulates	drug	0.70
NBR1	regulates	protein	0.70
MTOR	activates	gene	0.70
LRP1	regulates	gene	0.70
MAPT	encodes	gene	0.70
ALZHEIMER	biomarker_for	gene	0.60
TSG101	stabilizes	gene	0.60
RAB7A	stabilizes	gene	0.60
CHMP6	stabilizes	gene	0.60
DEMENTIA	stabilizes	gene	0.60
ALZHEIMER	activates	gene	0.60
TAUOPATHY	stabilizes	gene	0.60
CSNK2A1	activates	gene	0.60
TAU	activates	gene	0.60
HNRNPA2B1	activates	gene	0.60
DNA	activates	gene	0.60
NOTCH1	activates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
HDAC	inhibits	gene	0.60
ALZHEIMER	stabilizes	gene	0.60
ALZHEIMER	protects_against	gene	0.60
AMYLOID	stabilizes	gene	0.60
ENDOSOME	stabilizes	gene	0.60
TAU	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MICROTUBULES	stabilizes	gene	0.60
LYSOSOME	stabilizes	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
APOE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
ASTROCYTES	associated_with	gene	0.60
NF-KB	therapeutic_target	gene	0.60
MICROTUBULES	interacts_with	gene	0.60
NFKB	inhibits	gene	0.60
DEMENTIA	biomarker_for	gene	0.60
DEMENTIA	causes	gene	0.60
NEUROGRANIN	biomarker_for	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Pericyte senescence is sufficient to weaken the BBB even wit	0.630	neurodegeneration	Does pericyte senescence drive BBB break

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAU PROTEIN in their description or question text

No additional research found