| Gene Symbol | CHIP |
| Aliases | STUB1 |
| Function | E3 ubiquitin ligase catalytic domain |
| Molecular Weight | 34.5 kDa |
| Pathways | Dna Repair, Dna Damage Response |
| GeneCards | CHIP |
| Human Protein Atlas | CHIP |
| Location | C-terminal region |
| Binding | Binds to the C-terminal EEVD motif of chaperones |
| Importance | Required for full ubiquitin ligase activity |
| Mechanism | Interacts with E2 ubiquitin-conjugating enzymes |
| Misfolded proteins | Endoplasmic reticulum proteins |
| Chaperone clients | HSP70/HSP90 substrates |
| Disease proteins | Aggregation-prone proteins |
| Heat shock | Regulates HSF1 activity |
| Associated Diseases | ALS, Alzheimer, Alzheimer'S Disease, cardiovascular disease, Chronic Kidney Disease |
| Interactions | ACTB, ALS4, ALZHEIMER, AMYLOID, amyotrophic lateral sclerosis, APP |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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