protein

CALCINEURIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCINEURIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

322Connections

7Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

CALCINEURIN is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, treats. Associated with ALS, Als, Alzheimer. Connected to 138 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	PPP3CA
Full Name	Protein Phosphatase 3 Catalytic Subunit Alpha (Calcineurin)
Aliases	Calcineurin
Chromosome	4p16.3
Protein Type	Phosphatase
Function	is a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979].
Primary Expression	a tissue-specific manner:
Molecular Weight	59 kDa
Amino Acids	521 aa
Exons	14
GeneCards	PPP3CA
Human Protein Atlas	PPP3CA
Associated Diseases	Axon Repulsion, neurodegeneration
Interactions	NLRP3
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PPP3CA — Protein Phosphatase 3 Catalytic Subunit Alpha

gene · 1663 words

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Pathway Diagram

graph TD
    CALCINEURIN["CALCINEURIN"]
    CALCINEURIN -->|"activates"| TFEB["TFEB"]
    CALCINEURIN -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CALCINEURIN -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CALCINEURIN -->|"activates"| Ataxia["Ataxia"]
    CALCINEURIN -->|"activates"| Als["Als"]
    CALCINEURIN -->|"activates"| Parkinson["Parkinson"]
    CALCINEURIN -->|"activates"| Huntington["Huntington"]
    CALCINEURIN -->|"regulates"| Ms["Ms"]
    RCAN1["RCAN1"] -->|"inhibits"| CALCINEURIN
    STIP1["STIP1"] -->|"activates"| CALCINEURIN
    LGALS3["LGALS3"] -->|"activates"| CALCINEURIN
    HSPA8["HSPA8"] -->|"activates"| CALCINEURIN
    MCOLN1["MCOLN1"] -->|"activates"| CALCINEURIN
    SQSTM1["SQSTM1"] -->|"activates"| CALCINEURIN
    SOD1["SOD1"] -->|"activates"| CALCINEURIN
    BCL2["BCL2"] -->|"activates"| CALCINEURIN
    CTSB["CTSB"] -->|"activates"| CALCINEURIN
    TPP1["TPP1"] -->|"activates"| CALCINEURIN

Outgoing (209)

Target	Relation	Type	Str
Als	regulates	disease	0.75
TFEB	activates	protein	0.70
Depression	contributes_to	disease	0.65
Cardiac	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	activates	disease	0.65
Huntington	activates	disease	0.65
Ms	inhibits	disease	0.65
Depression	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	activates	disease	0.65
Ataxia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Cardiovascular	treats	disease	0.65
Heart Failure	associated_with	disease	0.65
Cardiac	treats	disease	0.65
Schizophrenia	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Schizophrenia	causes	disease	0.65
Spinocerebellar Ataxia	activates	disease	0.65
ALS	activates	disease	0.65
Als	expressed_in	disease	0.65
Obesity	regulates	disease	0.65
Cancer	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Bipolar	expressed_in	disease	0.65
Depression	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Bipolar	causes	disease	0.65
Neuroblastoma	activates	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PARKINSON	activates	gene	0.60
ATG	activates	gene	0.60
Stem Cell	activates	pathway	0.60
HUNTINGTON	activates	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NAD	regulates	gene	0.60
CANCER	regulates	gene	0.60

Incoming (113)

Source	Relation	Type	Str
Cyclosporine A	inhibits	drug	0.95
RCAN1	inhibits	protein	0.70
TREHALOSE	activates	gene	0.60
DNA	activates	gene	0.60
PPP3	activates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
NEPRILYSIN	regulates	gene	0.60
CAMKII	regulates	gene	0.60
AND	expressed_in	gene	0.60
AQUAPORIN-4	degrades	gene	0.60
AMYLOID	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PPP3CB	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
PKC	contributes_to	gene	0.60
MYC	regulates	gene	0.60
DRP1	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TFEB	regulates	gene	0.60
TFAM	regulates	gene	0.60
CBL7	activates	gene	0.60
TLR4	expressed_in	gene	0.60
AIFM1	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
TREM2	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
PYCARD	expressed_in	gene	0.60
LRP1	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
TLR2	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
MAPK1	expressed_in	gene	0.60
BDNF	activates	gene	0.60
HTT	activates	gene	0.60
HUNTINGTIN	activates	gene	0.60
SMPD1	inhibits	gene	0.60
GRIN2A	activates	gene	0.60
GAIN	therapeutic_target	gene	0.60
SMPD1	therapeutic_target	gene	0.60
BCL2	expressed_in	gene	0.60
MAPK14	expressed_in	gene	0.60
NLRP1	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
GSK3B	expressed_in	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Spatiotemporal coupling between TRPML1-mediated lysosomal ca	0.705	neurodegeneration	What determines the specificity of calci
mTORC1 displacement from lysosomal surface enables calcineur	0.650	neurodegeneration	What determines the specificity of calci
Calmodulin isoform switching from CaMK to calcineurin activa	0.607	neurodegeneration	What determines the specificity of calci
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.584	neurodegeneration	How does PIKFYVE inhibition activate unc
Calcineurin-FUNDC1 Axis as a Master Switch for Mitophagy vs.	0.430	neurodegeneration	What determines organelle-specific autop

P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to S	0.423	neurodegeneration	How do perivascular cells specifically r
Reticulocalbin-2 bridges calcineurin to lysosomal membranes	0.360	neurodegeneration	What determines the specificity of calci

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism	exploratory	motoneuron degeneration	0.800	0.00	neuronal cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CALCINEURIN in their description or question text

P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription vi

Score: 0.423 · neurodegeneration · 2026-04-22

## Mechanistic Overview P2X7/P2Y12 Purinergic Signaling Connects Aβ Aggregation to SPP1 Transcription via Calcineurin/NF

Reticulocalbin-2 bridges calcineurin to lysosomal membranes for Ca2+-dependent a

Score: 0.360 · neurodegeneration · 2026-04-21

## Mechanistic Overview Reticulocalbin-2 bridges calcineurin to lysosomal membranes for Ca2+-dependent activation starts