gene

CLPP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLPP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic)

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CLPP
Full Name	Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit
Aliases	Caseinolytic Mitochondrial Matrix Peptidase Proteolytic
Chromosome	19p13.3
Protein Type	Protease
Molecular Weight	23.4 kDa
Amino Acids	473 aa
Pathways	Mitochondrial Proteostasis
UniProt ID	[Q9NZJ5](https://www.uniprot.org/uniprot/Q9NZJ5)
Ensembl ID	ENSG00000139289
GeneCards	CLPP
Human Protein Atlas	CLPP
Heptad repeat regions	Oligomerization domains
Protease active sites	Ser-His-Asp catalytic triad
N-terminal signal peptide	Mitochondrial targeting (cleaved)
Associated Diseases	Aging, Als, Ataxia, frontotemporal dementia, Ftd, Ms
Interactions	Akt, AKT, CHCHD2, DNM1L, DRP1, FBXO7
KG Connections	238 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic)

gene · 907 words

→

CLPP Protein

protein · 1228 words

→

Pathway Diagram

graph TD
    CLPP["CLPP"]
    CLPP -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CLPP -->|"target for"| Aging["Aging"]
    CLPP -->|"target for"| Ms["Ms"]
    CLPP -->|"transports"| ALS["ALS"]
    CLPP -->|"target for"| RAB11["RAB11"]
    CLPP -->|"target for"| STX17["STX17"]
    CLPP -->|"target for"| RAB5["RAB5"]
    CLPP -->|"target for"| SNAP29["SNAP29"]
    CLPP -->|"target for"| IGF2BP1["IGF2BP1"]
    CLPP -->|"target for"| BDNF["BDNF"]
    ELAVL2["ELAVL2"] -->|"target for"| CLPP
    C1Q["C1Q"] -->|"target for"| CLPP
    MTOR["MTOR"] -->|"target for"| CLPP
    PI3K["PI3K"] -->|"target for"| CLPP
    AUTOPHAGY["AUTOPHAGY"] -->|"target for"| CLPP
    SNAP29 -->|"target for"| CLPP
    IGF2BP1 -->|"target for"| CLPP
    FUS["FUS"] -->|"target for"| CLPP
    AKT["AKT"] -->|"target for"| CLPP
    BDNF -->|"target for"| CLPP

Outgoing (167)

Target	Relation	Type	Str
Proteostasis	involved_in	process	0.85
mitochondrial protein degradation	mediates	process	0.85
Mitochondrial Proteostasis	involved_in	process	0.85
Neurodegeneration	encodes	disease	0.65
Als	transports	disease	0.65
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	encodes	disease	0.65
Ataxia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
ALS	transports	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Wnt	therapeutic_target	pathway	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
TP53	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
Autophagy	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Complement	therapeutic_target	pathway	0.60
FTD	associated_with	entity	0.60
RNF216	associated_with	gene	0.60
MAPK	encodes	gene	0.60
YTHDF1	encodes	gene	0.60
AUTOPHAGY	encodes	gene	0.60
METTL3	encodes	gene	0.60
Autophagy	encodes	pathway	0.60
Mapk	encodes	pathway	0.60
Wnt	encodes	pathway	0.60
Mtor	encodes	pathway	0.60
Neuron	encodes	cell_type	0.60
Interneuron	encodes	cell_type	0.60
Albumin	encodes	protein	0.60
Bdnf	encodes	protein	0.60
Tdp-43	encodes	protein	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
P53	therapeutic_target	protein	0.60
Igf	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
Pi3K	therapeutic_target	pathway	0.60
Akt	therapeutic_target	pathway	0.60

Incoming (71)

Source	Relation	Type	Str
NEURODEGENERATION	therapeutic_target	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
ALS	associated_with	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
C1Q	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
RAB5	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
LONP1	associated_with	gene	0.60
STX17	therapeutic_target	gene	0.60
AGING	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
AND	causes	gene	0.60
LYSOSOME	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	transports	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CHCHD2	activates	gene	0.60
COMPLEMENT	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
WNT	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
WNT	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
RNA	associated_with	gene	0.60
BDNF	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
FUS	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
C1Q/C3	associated_with	gene	0.60
RAB11	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
STX17	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
ELAVL2	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
LONP1	transports	gene	0.60
C1Q	associated_with	gene	0.60
ELAVL2	encodes	gene	0.60
SNAP29	encodes	gene	0.60
FUS	encodes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLPP in their description or question text

No additional research found