gene

TPP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TPP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with Als, Amyotrophic Lateral Sclerosis, Ataxia. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TPP1
Aliases	Page for TPP1 Gene, Tripeptidyl Peptidase 1
Chromosome	11p15.4
Protein Family	S9 family serine proteases
Function	It displays tripeptidyl-peptidase activity, cleaving N-terminal tripeptides from various substrates[1].
Molecular Weight	59 kDa
Amino Acids	563 aa
Exons	13
Pathways	Chaperone, Tdp-43, autophagy pathway, oxidative stress response
UniProt ID	O14773
NCBI Gene ID	1201
Ensembl ID	ENSG00000142149
OMIM	607998
GeneCards	TPP1
Human Protein Atlas	TPP1
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	AIF1, amyotrophic lateral sclerosis, AR, ATG, ATG10, ATG12
KG Connections	212 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TPP1 — AlphaFold O14773 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TPP1["TPP1"]
    TPP1 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TPP1 -->|"interacts"| Als["Als"]
    TPP1 -->|"activates"| CALCINEURIN["CALCINEURIN"]
    TPP1 -->|"activates"| ATG12["ATG12"]
    TPP1 -->|"activates"| ATG10["ATG10"]
    TPP1 -->|"interacts"| Akt["Akt"]
    TPP1 -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    TPP1 -->|"activates"| GENES["GENES"]
    TPP1 -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    TPP1 -->|"expressed in"| Neuron["Neuron"]
    GENES -->|"activates"| TPP1
    CALCINEURIN -->|"activates"| TPP1
    ATG12 -->|"activates"| TPP1
    POT1["POT1"] -->|"interacts"| TPP1
    TREHALOSE["TREHALOSE"] -->|"activates"| TPP1

Outgoing (101)

Target	Relation	Type	Str
blood-brain barrier	participates_in	pathway	0.70
Neuroblastoma	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Als	interacts_with	disease	0.65
cerebellum	expressed_in	brain_region	0.60
VEGFB	interacts_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Parkinson's disease	activates	disease	0.60
Huntington's disease	activates	disease	0.60
ALS	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
TREH	activates	entity	0.60
Neural Progenitor	associated_with	cell_type	0.60
neurodegeneration	activates	disease	0.60
Chaperone	associated_with	pathway	0.60
Akt	interacts_with	pathway	0.60
Tdp-43	associated_with	pathway	0.60
Sod1	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Alzheimer's disease	interacts_with	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
ALS	interacts_with	disease	0.60
multiple sclerosis	interacts_with	disease	0.60
astrocytes	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
P62	associated_with	gene	0.60
PPP3	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ATG	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
GENES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.60
AUTOPHAGY	associated_with	gene	0.60
Neuron	activates	cell_type	0.60
Ras	associated_with	protein	0.60
STIP1	associated_with	gene	0.60
CTSB	associated_with	gene	0.60

Incoming (111)

Source	Relation	Type	Str
ATP	interacts_with	gene	0.60
LDL	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
TARDBP	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BAG3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
GLA	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TREH	associated_with	gene	0.60
ATG10	activates	gene	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
PPP3	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
AR	activates	gene	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
ALS	activates	entity	0.60
RNA	activates	gene	0.60
POT1	interacts_with	gene	0.60
AIF1	interacts_with	gene	0.60
CTSB	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CTSL	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
IBA1	interacts_with	gene	0.60
LAMP1	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
NCL	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
ATG	activates	gene	0.60
DNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TPP1 in their description or question text

No additional research found