protein 1,146 words KG: STUB1
Contents

STUB1/CHIP Protein

🔬 Protein Info
Gene SymbolSTUB1
Full NameSTIP1 Homology And U-Box Containing Protein 1
AliasesCHIP
Chromosome16p13.3
Protein FamilyU-box E3 ubiquitin ligase family
Functionencodes a ubiquitin ligase and cochaperone that plays critical roles in protein quality control
Molecular Weight34.6 kDa
Amino Acids305 aa
PathwaysChaperone, Proteasome, Ubiquitin-Proteasome
UniProt IDQ9UNE7
NCBI Gene ID10273
Ensembl IDENSG00000120539
OMIM607207
GeneCardsSTUB1
Human Protein AtlasSTUB1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, dementia, frontotemporal, Huntington
Known Drugs/Compoundsrapamycin
Interactionsamyotrophic lateral sclerosis, AR, ATG, ATG10, ATG12, AUTOPHAGY
SciDEX Hypotheses
KG Connections242 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (15)

Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
VCP-Mediated Autophagy Enhancement
Score: 0.59
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (10)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ar
gene · KG edge: activates
ATG10 Gene
gene · KG edge: activates
ATG12 — Autophagy Related 12
gene · KG edge: activates

Knowledge Graph (12 edges)

STIP1 associated_with STUB1
LGALS3 associated_with STUB1
HSPA8 associated_with STUB1
MCOLN1 associated_with STUB1
SQSTM1 associated_with STUB1
SOD1 associated_with STUB1
BCL2 associated_with STUB1
CTSB associated_with STUB1
TPP1 associated_with STUB1
GLA associated_with STUB1

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