protein

NPTX1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPTX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

50Outgoing

42Incoming

0Experiments

0Debates

Summary

NPTX1 (Neuronal Pentraxin 1) - synaptic plasticity, complement-mediated synapse elimination, neuronal excitability, implicated in Alzheimer's disease and epilepsy

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🔬 Protein Info

Gene Symbol	NPTX1
Aliases	Neuronal Pentraxin 1
Function	Neuronal Pentraxin 1 (NPTX1) is a member of the pentraxin family of proteins, which are characterized by their ability to bind to phosphatidylserine and apoptotic cells.
Subcellular Localization	</strong></td><td>Extracellular, synaptic vesicles, secreted</td></tr>
Molecular Weight	47 kDa
Amino Acids	430 aa
Pathways	oxidative stress response
Ensembl ID	ENSG00000143157
GeneCards	NPTX1
Human Protein Atlas	NPTX1
Pentamers	Basic structural unit
Higher-order aggregates	Formed under certain conditions
Heteromeric complexes	Can interact with NPTX2
Associated Diseases	Inflammation, Neuroinflammation
Interactions	AMYLOID, CHI3L1, CHIT1, CST3, CTSB, CTSD
KG Connections	111 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NPTX1["NPTX1"]
    Neurodegeneration{"Neurodegeneration"}
    NPTX1 -->|"biomarker for"| Neurodegeneration
    Als{"Als"}
    NPTX1 -->|"biomarker for"| Als
    Inflammation{"Inflammation"}
    NPTX1 -->|"associated with"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    NPTX1 -->|"associated with"| Neuroinflammation
    Alzheimer{"Alzheimer"}
    NPTX1 -->|"biomarker for"| Alzheimer
    ALS{"ALS"}
    NPTX1 -->|"biomarker for"| ALS
    CHIT1["CHIT1"]
    NPTX1 -->|"associated with"| CHIT1
    MDH1["MDH1"]
    NPTX1 -->|"biomarker for"| MDH1
    PDGFRB["PDGFRB"]
    NPTX1 -->|"associated with"| PDGFRB
    SQSTM1["SQSTM1"]
    NPTX1 -->|"biomarker for"| SQSTM1
    BDNF["BDNF"]
    NPTX1 -->|"biomarker for"| BDNF
    APOE["APOE"]
    NPTX1 -->|"biomarker for"| APOE
    IL9["IL9"]
    IL9 -->|"biomarker for"| NPTX1
    VEGFA["VEGFA"]
    VEGFA -->|"associated with"| NPTX1
    IL4["IL4"]
    IL4 -->|"biomarker for"| NPTX1
    FGF2["FGF2"]
    FGF2 -->|"biomarker for"| NPTX1
    GFAP["GFAP"]
    GFAP -->|"biomarker for"| NPTX1
    SQSTM1 -->|"biomarker for"| NPTX1
    CHIT1 -->|"associated with"| NPTX1
    NEFL["NEFL"]
    NEFL -->|"biomarker for"| NPTX1
    CHI3L1["CHI3L1"]
    CHI3L1 -->|"associated with"| NPTX1
    MDH1 -->|"biomarker for"| NPTX1
    BDNF -->|"biomarker for"| NPTX1
    PDGFRB -->|"associated with"| NPTX1
    style NPTX1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (69)

Target	Relation	Type	Str
Synaptic Function	biomarker_for	process	0.85
ALS	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Fgf	biomarker_for	protein	0.60
App	biomarker_for	protein	0.60
oxidative stress response	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
Bdnf	biomarker_for	protein	0.60
VEGFA	associated_with	gene	0.60
GFAP	biomarker_for	gene	0.60
IL4	biomarker_for	gene	0.60
IL9	biomarker_for	gene	0.60
TAU	associated_with	gene	0.60
FGF2	biomarker_for	gene	0.60
PLD3	implicated_in	gene	0.60
PUM1	implicated_in	gene	0.60
STUB1	implicated_in	gene	0.60
RBFOX3	associated_with	gene	0.60
Cerebrovascular	associated_with	pathway	0.60
APOE Ε4	biomarker_for	gene	0.60
Aβ	biomarker_for	protein	0.60
Cytokine	biomarker_for	protein	0.60
Amyloid-Beta	biomarker_for	protein	0.60
Pdgf	associated_with	protein	0.60
AND	associated_with	gene	0.60
PDGFRB	biomarker_for	entity	0.60
TAU	biomarker_for	entity	0.60
VEGFA	biomarker_for	entity	0.60
PDGFRB	activates	gene	0.60
neuroinflammation	activates	disease	0.60
PDGFRB	interacts_with	gene	0.60
neuroinflammation	interacts_with	disease	0.60
Amyloid	biomarker_for	pathway	0.60
AMYLOID	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
INFLAMMATION	associated_with	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
Rb	associated_with	protein	0.60
CTSB	inhibits	gene	0.60
CTSD	inhibits	gene	0.60

Incoming (42)

Source	Relation	Type	Str
ALZHEIMER	biomarker_for	gene	0.60
AMYLOID	inhibits	gene	0.60
APOE Ε4	biomarker_for	gene	0.60
SQSTM1	biomarker_for	gene	0.60
CHIT1	associated_with	gene	0.60
NEFL	biomarker_for	gene	0.60
CHI3L1	associated_with	gene	0.60
MDH1	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
PDGFRB	associated_with	gene	0.60
CHI3L1	interacts_with	gene	0.60
TAU PATHOLOGY	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
FTLD	associated_with	gene	0.60
CHI3L1	biomarker_for	entity	0.60
CHIT1	biomarker_for	entity	0.60
NEUROINFLAMMATION	biomarker_for	entity	0.60
TAU	associated_with	gene	0.60
CST3	inhibits	gene	0.60
CTSS	inhibits	gene	0.60
DAB1	implicated_in	gene	0.60
FGF14	implicated_in	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	biomarker_for	gene	0.60
INFLAMMATION	associated_with	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
NEFL	associated_with	gene	0.60
CHI3L1	activates	gene	0.60
CHIT1	activates	gene	0.60
CNP	associated_with	gene	0.60
IL9	biomarker_for	gene	0.60
VEGFA	associated_with	gene	0.60
IL4	biomarker_for	gene	0.60
FGF2	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
APOE	biomarker_for	gene	0.60
Neuroinflammation	interacts_with	process	0.50
PDGFRB	interacts_with	gene	0.50
CHIT1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPTX1 in their description or question text

No additional research found