gene

TAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

255Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TAK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 152 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TAK1
Aliases	Transforming Growth Factor-beta-Activated Kinase 1
Chromosome	6q15
Protein Family	MAP3K kinases
Protein Type	Kinase
Function	TAK1 (Transforming Growth Factor-beta-Activated Kinase 1) is a serine/threonine kinase that activates NF-κB and MAPK pathways in response to cytokines (TNF-α, IL-1), TLR ligands, and stress.
Molecular Weight	67 kDa
Pathways	NF-κB, MAPK pathway, NF-κB Signaling, MAPK Signaling, MAPK
UniProt ID	[O43318](https://www.uniprot.org/uniprot/O43318)
GeneCards	TAK1
Human Protein Atlas	TAK1
Associated Diseases	Encephalitis, Multiple Sclerosis, neuroinflammation
Interactions	ALOX12, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	255 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TAK1["TAK1"] -->|"activates"| Cancer["Cancer"]
    TAK1["TAK1"] -->|"activates"| Als["Als"]
    TAK1["TAK1"] -->|"activates"| Ms["Ms"]
    TAK1["TAK1"] -.->|"inhibits"| Als_1["Als"]
    TAK1["TAK1"] -->|"therapeutic target"| Cancer_2["Cancer"]
    TAK1["TAK1"] -.->|"inhibits"| Tumor["Tumor"]
    P38["P38"] -->|"activates"| TAK1["TAK1"]
    MAP1LC3["MAP1LC3"] -->|"activates"| TAK1["TAK1"]
    IL1B["IL1B"] -->|"activates"| TAK1["TAK1"]
    PRDX1["PRDX1"] -->|"activates"| TAK1["TAK1"]
    style TAK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (176)

Target	Relation	Type	Str
TNF-α signaling	regulates	pathway	0.88
Als	activates	disease	0.85
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
UBIQUITIN	activates	gene	0.80
CANCER	activates	gene	0.80
Cancer	therapeutic_target	disease	0.75
AUTOPHAGY	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Inflammation	inhibits	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Aging	activates	disease	0.65
Ms	regulates	disease	0.65
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Huntington	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Encephalitis	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Infection	activates	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Glycolysis	activates	pathway	0.60
CXCL10	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
JUN	activates	gene	0.60
pyroptosis	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
NRF2	activates	gene	0.60
NFE2L2	activates	gene	0.60
TFE3	activates	gene	0.60
P62	activates	gene	0.60
STK11	activates	gene	0.60
JNK	activates	gene	0.60
TAB2	activates	gene	0.60
AND	activates	gene	0.60
Podocyte	inhibits	cell_type	0.60
USP9X	activates	gene	0.60
neuroinflammation	associated_with	disease	0.60
neuroinflammation	inhibits	disease	0.60
Apoptosis	regulates	pathway	0.60

Incoming (79)

Source	Relation	Type	Str
MAP3K7	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
STUB1	interacts_with	gene	0.60
TIGAR	activates	gene	0.60
ALOX12	activates	gene	0.60
MAP1LC3	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
AMYLOID-BETA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
LC3	activates	gene	0.60
IKBKB	activates	gene	0.60
IL6	activates	gene	0.60
MAPK8	inhibits	gene	0.60
JUN	therapeutic_target	gene	0.60
MAP3K7	inhibits	gene	0.60
ERN1	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
NLRP3	activates	gene	0.60
ASC	activates	gene	0.60
CANCER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
NF-KB	activates	gene	0.60
NFKB	activates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
TFEB	activates	gene	0.60
PP2A	activates	gene	0.60
KEAP1	activates	gene	0.60
SQSTM1	activates	gene	0.60
KRAS	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
TLR	activates	gene	0.60
NF-ΚB	interacts_with	gene	0.60
AMPK	activates	gene	0.60
MAPK	activates	gene	0.60
ERK1	therapeutic_target	gene	0.60
JNK1	therapeutic_target	gene	0.60
FTH1	activates	gene	0.60
UBE2N	activates	gene	0.60
ROS	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APP/PS1	activates	gene	0.60
LYSOSOME	activates	gene	0.60
INFLAMMATION	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TAK1 in their description or question text

No additional research found

TAK1

Understanding Entity Pages

Summary

Wiki Pages (8)

TAK1 Protein

TAB1 — TAK1-Binding Protein 1

TAK1 Protein

RIPK1-TAK1 Interaction Inhibitor

TAB2 Protein (TAK1-Binding Protein 2)

TAB3 Protein — TAK1-Binding Protein 3

TAK1 Gene

TAB1 Protein (TAK1-Binding Protein 1)