gene

LARS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LARS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

0Hypotheses

0Analyses

28Outgoing

14Incoming

0Experiments

0Debates

Summary

LARS2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, inhibits. Associated with Ataxia, Ms. Connected to 28 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LARS2
Full Name	Leucyl-tRNA Synthetase 2, Mitochondrial
Chromosome	3p21.31
Protein Type	Synthetase
Function	encodes a mitochondrial aminoacyl-tRNA synthetase that catalyzes the attachment of leucine to mitochondrial tRNA molecules.
Pathways	Differentiation, Mitochondrial Function
UniProt ID	Q9H3K1
NCBI Gene ID	57505
Ensembl ID	ENSG00000090339
OMIM	615912
GeneCards	LARS2
Human Protein Atlas	LARS2
Associated Diseases	Ataxia, Cognitive Impairment, Ms
Interactions	AND, ATP, DRP1, MFN1, MFN2, OPA1
KG Connections	42 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LARS2 — AlphaFold Q9H3K1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LARS2 — Leucyl-tRNA Synthetase 2, Mitochondrial

gene · 2642 words

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Pathway Diagram

graph TD
    LARS2["LARS2"]
    Ms{"Ms"}
    LARS2 -->|"activates"| Ms
    LARS2 -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    LARS2 -->|"associated with"| Ataxia
    MFN2["MFN2"]
    LARS2 -->|"inhibits"| MFN2
    RUNX2["RUNX2"]
    LARS2 -->|"activates"| RUNX2
    PIEZO1["PIEZO1"]
    LARS2 -->|"activates"| PIEZO1
    Mitochondrial_Function(["Mitochondrial Function"])
    LARS2 -->|"activates"| Mitochondrial_Function
    POLG["POLG"]
    LARS2 -->|"associated with"| POLG
    SIL1["SIL1"]
    LARS2 -->|"associated with"| SIL1
    STUB1["STUB1"]
    LARS2 -->|"associated with"| STUB1
    FMR1["FMR1"]
    LARS2 -->|"associated with"| FMR1
    TWNK["TWNK"]
    LARS2 -->|"associated with"| TWNK
    DRP1["DRP1"]
    DRP1 -->|"inhibits"| LARS2
    MFN1["MFN1"]
    MFN1 -->|"inhibits"| LARS2
    OPA1["OPA1"]
    OPA1 -->|"inhibits"| LARS2
    WFS1["WFS1"]
    WFS1 -->|"associated with"| LARS2
    HARS["HARS"]
    HARS -->|"associated with"| LARS2
    ATM["ATM"]
    ATM -->|"associated with"| LARS2
    CLPP["CLPP"]
    CLPP -->|"associated with"| LARS2
    SETX["SETX"]
    SETX -->|"associated with"| LARS2
    style LARS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (28)

Target	Relation	Type	Str
Alzheimer's Disease	targets	disease	0.95
Tau Phosphorylation	inhibits	process	0.90
Cognitive Impairment	associated_with	phenotype	0.90
Mitochondrial Function	regulates	process	0.90
Hippocampus	expressed_in	brain_region	0.85
PI3K-AKT Pathway	modulates	pathway	0.85
Ms	activates	disease	0.65
Ms	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
STUB1	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
POLG	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
DRP1	inhibits	gene	0.60
TWNK	associated_with	gene	0.60
SIL1	associated_with	gene	0.60
MFN2	inhibits	gene	0.60
PIEZO1	activates	gene	0.60
HARS	associated_with	gene	0.60
WFS1	associated_with	gene	0.60
SETX	associated_with	gene	0.60
ATP	activates	gene	0.60
Mitochondrial Function	implicated_in	pathway	0.60
Differentiation	activates	pathway	0.60
RNF216	associated_with	gene	0.60
MFN1	inhibits	gene	0.60
RUNX2	activates	gene	0.60
Mitochondrial Function	activates	pathway	0.60

Incoming (14)

Source	Relation	Type	Str
RUNX2	activates	gene	0.60
AND	activates	gene	0.60
DRP1	inhibits	gene	0.60
MFN1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
PNPLA6	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
WFS1	associated_with	gene	0.60
HARS	associated_with	gene	0.60
ATM	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
SETX	associated_with	gene	0.60
MFN2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LARS2 in their description or question text

No additional research found