gene

HSPB8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPB8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

HSPB8 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 106 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HSPB8
Full Name	Heat Shock Protein Family B Member 8
Chromosome	21q22.3
Protein Family	Small heat shock protein (sHsp)
Molecular Weight	22 kDa
Amino Acids	196 aa
Pathways	Autophagy
UniProt ID	Q9UJX1
NCBI Gene ID	23673
Ensembl ID	ENSG00000169435
OMIM	607655
GeneCards	HSPB8
Human Protein Atlas	HSPB8
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma
Known Drugs/Compounds	rapamycin
Interactions	amyotrophic lateral sclerosis, AND, AR, ATG, ATG10, ATG12
KG Connections	216 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPB8 — AlphaFold Q9UJX1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPB8 Gene

gene · 1270 words

→

HSPB8 Protein

protein · 995 words

→

Pathway Diagram

graph TD
    HSPB8["HSPB8"]
    HSPB8 -->|"component_of"| CASA_complex["CASA complex"]
    HSPB8 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    HSPB8 -->|"interacts"| Als["Als"]
    HSPB8 -->|"interacts"| Ms["Ms"]
    HSPB8 -->|"activates"| ATG10["ATG10"]
    HSPB8 -->|"activates"| GENES["GENES"]
    HSPB8 -->|"activates"| CALCINEURIN["CALCINEURIN"]
    HSPB8 -->|"activates"| ATG12["ATG12"]
    HSPB8 -->|"interacts"| Autophagy["Autophagy"]
    HSPB8 -->|"interacts"| BAG3["BAG3"]
    SQSTM1["SQSTM1"] -->|"participates in"| HSPB8
    MAP1LC3B["MAP1LC3B"] -->|"participates in"| HSPB8
    CALCINEURIN -->|"activates"| HSPB8
    ATG12 -->|"activates"| HSPB8
    STUB1["STUB1"] -->|"interacts"| HSPB8
    BAG3 -->|"interacts"| HSPB8
    GENES -->|"interacts"| HSPB8
    PROTEIN_MISFOLDING["PROTEIN MISFOLDING"] -->|"interacts"| HSPB8
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"interacts"| HSPB8
    AUTOPHAGY["AUTOPHAGY"] -->|"interacts"| HSPB8

Outgoing (140)

Target	Relation	Type	Str
chaperone-assisted selective autophagy	mediates	pathway	0.95
Tdp43 Lc Aggregation	inhibits	process	0.93
Tdp43 Lc Pre-Fibrillar Species	binds	protein	0.92
Stress Granules	expressed_in	cell_type	0.90
Amyloid-Like Fibril Formation	inhibits	process	0.90
HSPA	interacts_with	protein	0.90
CASA complex	component_of	protein	0.90
Protein Aggregation	modulates	process	0.88
Protein Degradation	mediates	pathway	0.85
Autophagy	associated_with	process	0.75
Spinocerebellar Ataxia	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	associated_with	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
TDP-43	associated_with	gene	0.60
cerebellum	expressed_in	brain_region	0.60
ATG	associated_with	gene	0.60
GENES	activates	gene	0.60
PPP3	associated_with	gene	0.60
DNA	associated_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Chaperone	associated_with	pathway	0.60
SOD1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
neurodegeneration	activates	disease	0.60
Ras	associated_with	protein	0.60
P62	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BECN1	associated_with	gene	0.60
ATG12	activates	gene	0.60
GLA	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
TREH	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
BAG3	interacts_with	gene	0.60
STUB1	interacts_with	gene	0.60
TFEB	associated_with	gene	0.60

Incoming (76)

Source	Relation	Type	Str
SQSTM1	participates_in	gene	0.80
MAP1LC3B	participates_in	gene	0.80
GLA	regulates	entity	0.60
STUB1	interacts_with	gene	0.60
BAG3	interacts_with	gene	0.60
LAMP2A	associated_with	gene	0.60
ATG10	regulates	entity	0.60
ATG12	regulates	entity	0.60
BAG3	regulates	entity	0.60
BECN1	regulates	entity	0.60
CTSB	regulates	entity	0.60
AR	activates	gene	0.60
GENES	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
RNA	associated_with	gene	0.60
ATG	activates	gene	0.60
DNA	activates	gene	0.60
rapamycin	targets	drug	0.60
STIP1	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
ATG	associated_with	gene	0.60
PROTEIN MISFOLDING	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
TREHALOSE	activates	gene	0.60
DNA	associated_with	gene	0.60
PPP3	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPB8 in their description or question text

No additional research found