gene

PPP3CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP3CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

191Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

PPP3CB is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 119 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PPP3CB
Chromosome	2p22.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	61 kDa
Amino Acids	524 aa
Pathways	Autophagy, Chaperone, Mtor, Tdp-43, autophagy pathway
UniProt ID	P16234
NCBI Gene ID	5519
Ensembl ID	ENSG00000107738
GeneCards	PPP3CB
Human Protein Atlas	PPP3CB
Calcineurin A (catalytic subunit)	60-61 kDa protein with catalytic domain
Calcineurin B (regulatory subunit)	19 kDa calcium-binding protein
N-terminal domain	Regulatory region with auto-inhibitory segment
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, Huntington, Neuroblastoma
Known Drugs/Compounds	rapamycin
Interactions	amyotrophic lateral sclerosis, AR, ATG, ATG10, ATG12, AUTOPHAGY
KG Connections	191 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPP3CB — AlphaFold P16234 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PPP3CB Gene

gene · 891 words

→

PPP3CB Protein

protein · 1294 words

→

Pathway Diagram

graph TD
    PPP3CB["PPP3CB"]
    PPP3CB -->|"binds"| TFEB["TFEB"]
    PPP3CB -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PPP3CB -->|"interacts"| Als["Als"]
    PPP3CB -->|"activates"| Ms["Ms"]
    PPP3CB -->|"activates"| ATG10["ATG10"]
    PPP3CB -->|"activates"| GENES["GENES"]
    PPP3CB -->|"activates"| CALCINEURIN["CALCINEURIN"]
    PPP3CB -->|"activates"| ATG12["ATG12"]
    SMURF1["SMURF1"] -->|"ubiquitinates"| PPP3CB
    LGALS3["LGALS3"] -->|"binds"| PPP3CB
    CALCINEURIN -->|"activates"| PPP3CB
    ATG12 -->|"activates"| PPP3CB
    CTSB["CTSB"] -->|"expressed in"| PPP3CB
    MTOR["MTOR"] -->|"activates"| PPP3CB
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"] -->|"activates"| PPP3CB
    TREHALOSE["TREHALOSE"] -->|"activates"| PPP3CB

Outgoing (117)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Huntington	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Ms	activates	disease	0.65
Neuroblastoma	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
SMURF1	activates	gene	0.60
Autophagy	associated_with	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
TAR	activates	gene	0.60
SMURF1	interacts_with	gene	0.60
Sod1	associated_with	pathway	0.60
Huntington's disease	activates	disease	0.60
RNA	activates	gene	0.60
ALS	activates	disease	0.60
PPP3	activates	gene	0.60
stem cells	expressed_in	cell_type	0.60
Neuron	activates	cell_type	0.60
PPP3	associated_with	gene	0.60
Ras	associated_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
ATG	associated_with	gene	0.60
Tdp-43	associated_with	pathway	0.60
PARKINSON	associated_with	gene	0.60
autophagy pathway	participates_in	pathway	0.60
Stem Cell	associated_with	pathway	0.60
TREHALOSE	activates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
AND	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
Chaperone	associated_with	pathway	0.60
Autophagy	activates	pathway	0.60
GENES	activates	gene	0.60
Mtor	associated_with	pathway	0.60
RNA	associated_with	gene	0.60
MTORC1	activates	gene	0.60
DNA	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
Mtor	activates	pathway	0.60
HUNTINGTON	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60

Incoming (74)

Source	Relation	Type	Str
TFEB	interacts_with	gene	0.85
LGALS3	associated_with	protein	0.70
PPP3	interacts_with	gene	0.60
CTSB	expressed_in	gene	0.60
MTOR	associated_with	gene	0.60
P62	associated_with	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
AR	activates	gene	0.60
P62	activates	entity	0.60
PPARGC1A	activates	entity	0.60
ATG	activates	gene	0.60
DNA	activates	gene	0.60
rapamycin	targets	drug	0.60
TARDBP	associated_with	gene	0.60
TREH	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
BAG3	activates	entity	0.60
BCL2	activates	entity	0.60
BECN1	activates	entity	0.60
CTSB	activates	entity	0.60
GAPDH	activates	entity	0.60
GLA	activates	entity	0.60
HSPA8	activates	entity	0.60
HSPB8	activates	entity	0.60
LAMP1	activates	entity	0.60
LAMP2A	activates	entity	0.60
LGALS3	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MCOLN1	activates	entity	0.60
GENES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
RNA	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
ATG12	activates	gene	0.60
STUB1	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
PPP3/calcineurin-dependent TFEB dephosphorylation mechanism	exploratory	motoneuron degeneration	0.800	0.00	neuronal cell lines	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPP3CB in their description or question text

No additional research found