gene

WFS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WFS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

1Analyses

21Outgoing

18Incoming

0Experiments

2Debates

Summary

WFS1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Ataxia, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WFS1
Full Name	Wolframin ER Calcium Channel
Aliases	Page for WFS1 Protein
Chromosome	4p16.1
Function	The WFS1 gene encodes wolframin, a transmembrane protein localized primarily to the endoplasmic reticulum (ER).
Primary Expression	Pancreas, Brain, Heart, Kidney, Eye
Molecular Weight	100.3 kDa
Amino Acids	890 aa
Pathways	signaling: - Activates Akt pathway
UniProt ID	O76024
NCBI Gene ID	7466
Ensembl ID	ENSG00000109501
OMIM	222300
GeneCards	WFS1
Human Protein Atlas	WFS1
Associated Diseases	Ataxia, Ms
Interactions	SRPK1
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WFS1 — AlphaFold O76024 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    WFS1["WFS1"]
    Ms{"Ms"}
    WFS1 -->|"associated with"| Ms
    Ataxia{"Ataxia"}
    WFS1 -->|"associated with"| Ataxia
    HARS["HARS"]
    WFS1 -->|"associated with"| HARS
    ATM["ATM"]
    WFS1 -->|"associated with"| ATM
    CLPP["CLPP"]
    WFS1 -->|"associated with"| CLPP
    SETX["SETX"]
    WFS1 -->|"associated with"| SETX
    LARS2["LARS2"]
    WFS1 -->|"associated with"| LARS2
    POLG["POLG"]
    WFS1 -->|"associated with"| POLG
    SIL1["SIL1"]
    WFS1 -->|"associated with"| SIL1
    STUB1["STUB1"]
    WFS1 -->|"associated with"| STUB1
    FMR1["FMR1"]
    WFS1 -->|"associated with"| FMR1
    TWNK["TWNK"]
    WFS1 -->|"associated with"| TWNK
    style WFS1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
intermediate AD stages	indicates	disease	0.70
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
oxidative stress response	participates_in	pathway	0.60
HARS	associated_with	gene	0.60
ATM	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Apoptosis	protects_against	pathway	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
SETX	associated_with	gene	0.60
LARS2	associated_with	gene	0.60
POLG	associated_with	gene	0.60
SIL1	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
FMR1	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60

Incoming (18)

Source	Relation	Type	Str
CLPP	associated_with	gene	0.60
ATM	associated_with	gene	0.60
PNPLA6	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TWNK	associated_with	gene	0.60
LARS2	associated_with	gene	0.60
SIL1	associated_with	gene	0.60
HARS	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
SRPK1	interacts_with	gene	0.60
SRPK1	associated_with	gene	0.60
APOPTOSIS	protects_against	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
RNF216	associated_with	gene	0.60
HLA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Spatial Transcriptomics Analysis of Alzheimer's Disease Brain Regions

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

How does spatial gene expression in the hippocampus and entorhinal cortex distin

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Do spatial transcriptomic neighborhoods provide sufficient discriminative power

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning WFS1 in their description or question text

No additional research found