gene

DAB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

141Connections

0Hypotheses

1Analyses

50Outgoing

42Incoming

0Experiments

1Debates

Summary

DAB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with ALS, Als, Alzheimer. Connected to 78 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DAB1
Full Name	Disabled-1
Chromosome	1p32-p31
Protein Family	Disabled family
Protein Type	Adaptor Protein
Function	is a key intracellular adaptor protein in the Reelin signaling pathway.
Subcellular Localization	Cytoplasm, postsynaptic densities
Molecular Weight	80 kDa
Amino Acids	625 aa
Pathways	Dendritic Spine, Synaptic Plasticity
UniProt ID	D3DX7A
NCBI Gene ID	1600
Ensembl ID	ENSG00000170522
OMIM	603448
GeneCards	DAB1
Human Protein Atlas	DAB1
Associated Diseases	Als, Alzheimer, Autism, Bipolar, Depression
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE3, APOER2
KG Connections	141 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DAB1 — AlphaFold D3DX7A Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DAB1 Gene

gene · 644 words

→

DAB1 Protein

protein · 1195 words

→

Pathway Diagram

graph TD
    DAB1["DAB1"]
    Ms{"Ms"}
    DAB1 -->|"interacts with"| Ms
    Als{"Als"}
    DAB1 -->|"interacts with"| Als
    Schizophrenia{"Schizophrenia"}
    DAB1 -->|"regulates"| Schizophrenia
    Epilepsy{"Epilepsy"}
    DAB1 -->|"regulates"| Epilepsy
    Alzheimer{"Alzheimer"}
    DAB1 -->|"regulates"| Alzheimer
    Autism{"Autism"}
    DAB1 -->|"regulates"| Autism
    Depression{"Depression"}
    DAB1 -->|"regulates"| Depression
    Bipolar{"Bipolar"}
    DAB1 -->|"regulates"| Bipolar
    DAB1 -->|"regulates"| Ms
    Neurodegeneration{"Neurodegeneration"}
    DAB1 -->|"therapeutic target"| Neurodegeneration
    DAB1 -->|"interacts with"| Schizophrenia
    Dementia{"Dementia"}
    DAB1 -->|"therapeutic target"| Dementia
    DCX["DCX"]
    DCX -->|"interacts with"| DAB1
    CDK5["CDK5"]
    CDK5 -->|"interacts with"| DAB1
    LIS1["LIS1"]
    LIS1 -->|"interacts with"| DAB1
    JUN["JUN"]
    JUN -->|"regulates"| DAB1
    PAFAH1B1["PAFAH1B1"]
    PAFAH1B1 -->|"interacts with"| DAB1
    SRC["SRC"]
    SRC -->|"associated with"| DAB1
    FYN["FYN"]
    FYN -->|"associated with"| DAB1
    CDK5 -->|"associated with"| DAB1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| DAB1
    APOE4["APOE4"]
    APOE4 -->|"associated with"| DAB1
    RELN["RELN"]
    RELN -->|"associated with"| DAB1
    CDK5 -->|"causes"| DAB1
    style DAB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (99)

Target	Relation	Type	Str
Reelin Signaling Pathway	component_of	pathway	0.90
superficial dorsal horn	expressed_in	brain_region	0.90
Reelin signaling pathway	involved_in	pathway	0.85
dI5 neuron migration	mediates	process	0.85
REELIN	interacts_with	entity	0.85
Reelin Signalling Pathway	involved_in	pathway	0.80
lamina V	contributes_to	brain_region	0.80
cytoskeletal_stability	promotes	pathway	0.80
Als	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
Depression	implicated_in	disease	0.65
ALS	causes	disease	0.65
Epilepsy	implicated_in	disease	0.65
Autism	implicated_in	disease	0.65
Bipolar	implicated_in	disease	0.65
Schizophrenia	implicated_in	disease	0.65
Als	causes	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Schizophrenia	regulates	disease	0.65
Epilepsy	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Autism	regulates	disease	0.65
Depression	regulates	disease	0.65
Bipolar	regulates	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
Amyloid	activates	pathway	0.60
Tau Phosphorylation	activates	pathway	0.60
PAFAH1B1	interacts_with	gene	0.60
FYN	associated_with	gene	0.60
REELIN	causes	gene	0.60
GAIN	activates	gene	0.60
REELIN	activates	gene	0.60
RELN	activates	gene	0.60
PSEN1	activates	gene	0.60
APOE3	activates	gene	0.60
TAU	activates	gene	0.60
Neuron	regulates	cell_type	0.60

Incoming (42)

Source	Relation	Type	Str
RELN	interacts_with	protein	0.90
reelin_protein	phosphorylates	protein	0.80
PAFAH1B1	interacts_with	gene	0.60
SRC	associated_with	gene	0.60
CDK5	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
RELN	associated_with	gene	0.60
CDK5	causes	gene	0.60
LIS1	causes	gene	0.60
REELIN	causes	gene	0.60
REELIN	associated_with	gene	0.60
APOER2	activates	gene	0.60
AMYLOID	activates	gene	0.60
APOE3	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
DEMENTIA	activates	gene	0.60
FYN	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PAFAH1B1	causes	gene	0.60
DCX	causes	gene	0.60
TAU	activates	gene	0.60
RELN	activates	gene	0.60
APP	interacts_with	gene	0.60
REELIN	interacts_with	gene	0.60
CLUSTERIN	interacts_with	gene	0.60
AXON	causes	gene	0.60
NEURON	causes	gene	0.60
MICROTUBULES	causes	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
EPILEPSY	regulates	gene	0.60
DCX	interacts_with	gene	0.60
CDK5	interacts_with	gene	0.60
LIS1	interacts_with	gene	0.60
JUN	regulates	gene	0.60
DYNEIN	causes	gene	0.60
EPILEPSY	implicated_in	gene	0.60
ALZHEIMER	implicated_in	gene	0.60
AND	associated_with	gene	0.60
APOER2	associated_with	gene	0.60
APOE	regulates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.696

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Why do entorhinal cortex layer II stellate neurons die first in AD? Their unique

closed · Rounds: 6 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning DAB1 in their description or question text

No additional research found