gene

ATG12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATG12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

459Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATG12 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with ALS, Aging, Als. Connected to 335 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ATG12
Full Name	Autophagy Related 12
Chromosome	5q21.2
Protein Family	ATG12 family
Function	is a ubiquitin-like protein that plays an essential role in autophagy, the cellular process for degrading and recycling damaged organelles and proteins.
Subcellular Localization	Cytoplasm, autophagosome membrane
Molecular Weight	~15 kDa
Pathways	Autophagy, Cell Cycle, Mitophagy
UniProt ID	O95166
NCBI Gene ID	9459
Ensembl ID	ENSG00000181458
GeneCards	ATG12
Human Protein Atlas	ATG12
Associated Diseases	Als, Alzheimer, Ataxia, Infection, Ms, Neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACTB, AGING, AKT, ALS, ALZHEIMER, AMPK
KG Connections	459 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATG12 — AlphaFold O95166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ATG12["ATG12"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ATG12["ATG12"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ATG12["ATG12"] -->|"activates"| Ataxia["Ataxia"]
    ATG12["ATG12"] -->|"activates"| Als["Als"]
    ATG12["ATG12"] -->|"activates"| Parkinson["Parkinson"]
    ATG12["ATG12"] -->|"activates"| Huntington["Huntington"]
    SQSTM1["SQSTM1"] -->|"participates in"| ATG12["ATG12"]
    AKT["AKT"] -->|"associated"| ATG12["ATG12"]
    AMPK["AMPK"] -->|"associated"| ATG12["ATG12"]
    APP["APP"] -->|"associated"| ATG12["ATG12"]
    style ATG12 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (283)

Target	Relation	Type	Str
Als	activates	disease	0.85
Autophagy	activates	pathway	0.80
Autophagy	interacts_with	pathway	0.80
Cancer	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
oxidative stress response	participates_in	pathway	0.70
MTOR	activates	gene	0.70
Mtor	activates	pathway	0.70
ULK1	interacts_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
Glioma	regulates	disease	0.65
Tumor	activates	disease	0.65
Spinocerebellar Ataxia	activates	disease	0.65
Aging	interacts_with	disease	0.65
Neuroblastoma	activates	disease	0.65
ALS	activates	disease	0.65
Infection	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	inhibits	disease	0.65
Dementia	interacts_with	disease	0.65
Infection	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Bacterial Infection	interacts_with	disease	0.65
Inflammation	inhibits	disease	0.65
Ataxia	activates	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	biomarker_for	disease	0.65
Parkinson	activates	disease	0.65
MITOCHONDRIA	associated_with	gene	0.65
NEURON	associated_with	gene	0.65
TAUOPATHY	associated_with	gene	0.65
Als	associated_with	disease	0.65
Huntington	activates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Lung Cancer	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Autoimmune	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
TFEB	associated_with	gene	0.65
ATG5	associated_with	gene	0.65
SIRT1	associated_with	gene	0.65
TAU	associated_with	gene	0.65
Tumor	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	activates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Ataxia	implicated_in	disease	0.65

Incoming (176)

Source	Relation	Type	Str
L1CAM	interacts_with	protein	0.90
SQSTM1	participates_in	gene	0.80
AUTOPHAGY	activates	gene	0.80
ATG	interacts_with	gene	0.80
LC3	interacts_with	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
P62	activates	gene	0.80
ATG5	activates	gene	0.80
GENES	activates	gene	0.70
CANCER	activates	gene	0.70
ATG5	interacts_with	gene	0.70
LC3	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
UBIQUITIN	interacts_with	gene	0.70
APP	associated_with	gene	0.65
AKT	associated_with	gene	0.65
AMPK	associated_with	gene	0.65
PROTEIN MISFOLDING	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
AMPK	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ENDOSOME	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
ENDOSOMES	implicated_in	gene	0.60
LNCRNA	activates	gene	0.60
STIP1	activates	gene	0.60
LGALS3	activates	gene	0.60
HSPA8	activates	gene	0.60
MCOLN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
SOD1	activates	gene	0.60
BCL2	activates	gene	0.60
CTSB	activates	gene	0.60
TPP1	activates	gene	0.60
GLA	activates	gene	0.60
CALCINEURIN	activates	gene	0.60
CYCS	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
UBC	associated_with	gene	0.60
ATG3	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
ATG7	activates	gene	0.60
SIRT1	activates	gene	0.60
BECLIN1	interacts_with	gene	0.60
ATG5	regulates	gene	0.60
RAB5	implicated_in	gene	0.60
ATG1	regulates	gene	0.60
RAB7	implicated_in	gene	0.60
MAP1LC3	associated_with	gene	0.60
ATG10	regulates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATG12 in their description or question text

No additional research found