concept

BERBERINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BERBERINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	BERBERINE
Key Genes/Proteins	AKT, AKT1, ALZHEIMER, AMPK, AMYLOID, AMYLOID-BETA
Related Diseases	Alzheimer'S Disease, ALZHEIMER'S DISEASE, APOPTOSIS, Autoimmune, AUTOPHAGY

Pathway Diagram

graph TD
    BERBERINE["BERBERINE"]
    BERBERINE -->|"inhibits"| Inflammation["Inflammation"]
    BERBERINE -->|"attenuates"| inflammatory_response["inflammatory response"]
    BERBERINE -->|"inhibits"| IL_1_["IL-1beta"]
    BERBERINE -->|"inhibits"| IL_6["IL-6"]
    BERBERINE -->|"inhibits"| TNF__["TNF-alpha"]
    BERBERINE -->|"inhibits"| NF__B_Signaling_Pathway["NF-kappaB Signaling Pathway"]
    BERBERINE -->|"targets"| IRGM1["IRGM1"]
    BERBERINE -->|"inhibits"| MAPK_Signaling_Pathway["MAPK Signaling Pathway"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"implicated in"| BERBERINE
    BCL2["BCL2"] -->|"target for"| BERBERINE
    APP["APP"] -->|"target for"| BERBERINE
    BAX["BAX"] -->|"target for"| BERBERINE

Outgoing (111)

Target	Relation	Type	Str
Inflammation	inhibits	process	0.98
TNF-α	inhibits	protein	0.95
IL-1β	inhibits	protein	0.95
IL-6	inhibits	protein	0.95
inflammatory response	attenuates	process	0.95
NF-κB Signaling Pathway	inhibits	pathway	0.95
Mapk Signaling Pathway	inhibits	pathway	0.95
IRGM1	targets	protein	0.95
TNF	inhibits	gene	0.95
IL1B	inhibits	gene	0.95
NFKB1	inhibits	gene	0.95
Inflammation	associated_with	process	0.95
Depression-Like Behaviors	treats	phenotype	0.95
NLRP3	inhibits	protein	0.95
MAPK Signaling Pathway	inhibits	pathway	0.92
MAPK signaling pathway	inhibits	pathway	0.90
Inflammatory Disease	treats	disease	0.90
STAT1	upregulates	gene	0.90
ulcerative colitis	treats	disease	0.90
NF-κB signaling pathway	inhibits	pathway	0.90
NFKBIA	suppresses	gene	0.90
Inflammatory Diseases	treats	disease	0.90
AKT1	binds_to	gene	0.90
PI3K/AKT/mTOR Pathway	inhibits	pathway	0.90
IRGM1	downregulates	protein	0.90
Ulcerative Colitis	treats	disease	0.90
IκBα	inhibits	protein	0.90
Synaptic Plasticity	protects_against	process	0.90
IκBα	inhibits	protein	0.90
Immune System Function	modulates	process	0.88
STAT1 Signaling Pathway	activates	pathway	0.85
Cell Membrane	interacts_with	cell_type	0.85
TNF	inhibits	protein	0.85
Autoimmune Disease	treats	disease	0.85
Adult Neurogenesis	activates	process	0.85
inflammatory diseases	treats	disease	0.80
GFAP	protects_against	protein	0.80
Primary Open-Angle Glaucoma	treats	disease	0.75
IL6	inhibits	protein	0.70
NF-kB signaling	modulates	pathway	0.70
ALZHEIMER'S DISEASE	inhibits	disease	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
TYROBP	activates	gene	0.65
TYROBP	regulates	gene	0.65
INFLAMMATION	treats	phenotype	0.65
NEUROINFLAMMATION	protects_against	phenotype	0.65
AMPK	activates	gene	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
AMYLOID-BETA	treats	protein	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65

Incoming (52)

Source	Relation	Type	Str
HIPPOCAMPUS	treats	brain_region	0.65
OXIDATIVE STRESS	associated_with	phenotype	0.55
disease	associated_with	disease	0.50
STAT1	activates	gene	0.50
IL-6	activates	protein	0.50
IL-1Β	activates	protein	0.50
IΚBΑ	activates	protein	0.50
inflammation	activates	pathway	0.50
MAPK	activates	gene	0.50
NF-κB	activates	concept	0.50
TNF-α	activates	concept	0.50
CYTOKINE	activates	concept	0.50
MAPK SIGNALING	activates	concept	0.50
Autoimmune	activates	disease	0.50
Endocytosis	regulates	pathway	0.50
DOPAMINE	regulates	concept	0.50
AKT1	interacts_with	gene	0.50
Neuroinflammation	inhibits	process	0.50
Sepsis	inhibits	disease	0.50
inflammation	inhibits	pathway	0.50
inflammation	associated_with	pathway	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
IL1B	associated_with	gene	0.50
MAPT	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
BCL2	associated_with	gene	0.50
SOD2	associated_with	gene	0.50
CASP3	associated_with	gene	0.50
ACHE	associated_with	concept	0.50
oxidative stress	regulates	phenotype	0.50
QUERCETIN	interacts_with	concept	0.50
Ulcerative Colitis	inhibits	disease	0.50
Ulcerative Colitis	associated_with	disease	0.50
METFORMIN	associated_with	drug	0.45
QUERCETIN	associated_with	drug	0.45
APP	associated_with	gene	0.45
BAX	associated_with	gene	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
NEUROGENESIS	associated_with	phenotype	0.45
RESVERATROL	associated_with	drug	0.45
AMYLOID-BETA	associated_with	protein	0.45
NICOTINAMIDE	associated_with	drug	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.35
BCL2	therapeutic_target	gene	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BERBERINE in their description or question text

No additional research found