protein

BMAL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BMAL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1396Connections

2Hypotheses

8Analyses

50Outgoing

50Incoming

6Experiments

10Debates

Summary

BMAL1 is a protein involved in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, ATHEROSCLEROSIS, Aging. Connected to 603 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BMAL1
Full Name	Aryl Hydrocarbon Receptor Nuclear Translocator-Like
Chromosome	11p15.3
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	BMAL1 is a bHLH-PAS transcription factor with critical functions
Mechanism of Action	Small molecule modulator of circadian transcription
Druggability	Low (0.34)
Clinical Stage	Phase I
Pathways	Akt, Apoptosis, Autophagy, CIRCADIAN_RHYTHM, Camp Signaling
UniProt ID	E9PL54
NCBI Gene ID	10518
Ensembl ID	ENSG00000141510
OMIM	602550
GeneCards	BMAL1
Human Protein Atlas	BMAL1
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	lithium, nicotinamide, SXD
Interactions	Actin, adamts4, ADAMTS4, AGING, AHR, AKT
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Circadian Rhythm Entrainment of Reactive Astrocyte
KG Connections	1392 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BMAL1 — AlphaFold E9PL54 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BMAL1["BMAL1"] -->|"regulates"| CIRCADIAN_RHYTHM["CIRCADIAN_RHYTHM"]
    BMAL1["BMAL1"] -.->|"inhibits"| DCM["DCM"]
    BMAL1["BMAL1"] -.->|"inhibits"| CARDIAC_HYPERTROPHY["CARDIAC_HYPERTROPHY"]
    BMAL1["BMAL1"] -.->|"inhibits"| DIASTOLIC_DYSFUNCTION["DIASTOLIC_DYSFUNCTION"]
    BMAL1["BMAL1"] -->|"expressed in"| CARDIOMYOCYTE["CARDIOMYOCYTE"]
    BMAL1["BMAL1"] -->|"interacts"| HIF2A["HIF2A"]
    SKELETAL_AGING["SKELETAL_AGING"] -.->|"inhibits"| BMAL1["BMAL1"]
    style BMAL1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (996)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:BMAL1	data_in	dataset_row	0.00
Circadian Clock	component_of	pathway	0.96
circadian rhythm	drives	process	0.95
Endothelial Cells	expressed_in	cell_type	0.95
Angiogenesis	regulates	process	0.95
Obesity	protects_against	disease	0.95
astrocyte activation	inhibits	process	0.95
Endothelial Cell Cycle	regulates	process	0.95
Myocardial Injury	modulates	phenotype	0.95
METABOLIC HEALTH	regulates	entity	0.95
ConA-Induced Liver Injury	regulates	disease	0.95
Glial Activation	modulates	process	0.90
Circadian Rhythms	involved_in	process	0.90
SLEEP-WAKE CYCLE	regulates	entity	0.90
Amyloid-Beta Deposition	modulates	process	0.90
NEURODEGENERATION	associated_with	entity	0.90
Cellular Metabolism	regulates	process	0.90
Obesity	implicated_in	disease	0.90
Intestine	expressed_in	cell_type	0.90
Circadian Rhythm Disruption	involved_in	process	0.90
Circadian Gene Expression	involved_in	process	0.90
Endothelial Cell Cycle Progression	mediates	process	0.90
SERPINE1	upregulates	gene	0.90
Astrocyte Activation	modulates	phenotype	0.90
sleep-wake cycle	regulates	process	0.90
Glioblastoma Growth	regulates	phenotype	0.90
Diabetic Cardiomyopathy	protects_against	disease	0.90
Tau Aggregation	regulates	phenotype	0.90
SNCA Aggregation	regulates	phenotype	0.90
neural stem cells	activates	cell_type	0.90
CLOCK	co_mentioned_with	gene	0.90
HIF2A	forms_heterodimer_with	gene	0.90
CDK1	upregulates	gene	0.90
neurodegeneration	associated_with	disease	0.90
tau aggregation	promotes	phenotype	0.90
EGLN2	inhibits	gene	0.90
alpha-synuclein aggregation	promotes	phenotype	0.90
Adiposity	regulates	phenotype	0.90
INTESTINE	expressed_in	cell_type	0.90
HIF2A	associated_with	protein	0.90
dietary fat absorption	associated_with	phenotype	0.90
CIRCADIAN RHYTHM	associated_with	gene	0.90
DGAT2	activates	gene	0.90
HIF1A	regulates	gene	0.90
Body Weight	regulates	phenotype	0.90
chondrocyte proliferation	associated_with	phenotype	0.90
VEGF	regulates	gene	0.90
Circadian Rhythm Regulation	regulates	process	0.90
LIPID METABOLISM	regulates	entity	0.90
HIF1A	interacts_with	entity	0.90

Incoming (400)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BMAL1	data_in	dataset_row	0.00
Astrocytes	expressed_in	cell_type	0.95
EXERCISE	inhibits	gene	0.95
Chronic Sleep Deprivation	causes	process	0.90
DNMT1	inhibits	protein	0.90
CLOCK	interacts_with	gene	0.90
SQSTM1	inhibits	protein	0.90
h-de52344d	targets_gene	hypothesis	0.90
h-5706bbd7	targets_gene	hypothesis	0.90
High Glucose and Palmitic Acid	downregulates	compound	0.85
Type 2 Diabetes	downregulates	disease	0.85
OBSTRUCTIVE SLEEP APNEA SYNDROME	modulates	entity	0.85
h-5706bbd7	targets	hypothesis	0.80
REV-ERBA	inhibits	gene	0.80
Obstructive Sleep Apnea Syndrome	modulates	disease	0.75
OSAS	modulates	disease	0.75
melatonin	regulates	drug	0.70
oxidative phosphorylation	regulates	pathway	0.70
exercise	regulates	process	0.70
IL17A	inhibits	protein	0.70
Amyloid beta	inhibits	protein	0.70
CLOCK	co_expressed_with	gene	0.70
PER	co_expressed_with	gene	0.70
NPAS2	interacts_with	protein	0.70
Blue light exposure	inhibits	process	0.70
SXD	activates	drug	0.70
PER1	expressed_in	gene	0.70
DNMT1	regulates	protein	0.70
PPARα	activates	protein	0.70
metformin	regulates	drug	0.70
ATG5	activates	gene	0.65
ATG7	activates	gene	0.65
nicotinamide	targets	drug	0.65
SKELETAL_AGING	inhibits	phenotype	0.64
ARNT	contributes_to	entity	0.60
AMYLOID-BETA	therapeutic_target	gene	0.60
ARNTL	activates	entity	0.60
ATM	activates	entity	0.60
BCL2	regulates	entity	0.60
CD68	activates	gene	0.60
TNF	activates	gene	0.60
NR1D1	regulates	gene	0.60
TAU	expressed_in	gene	0.60
GFAP	activates	gene	0.60
BDNF	expressed_in	gene	0.60
CRY2	expressed_in	gene	0.60
REST	expressed_in	gene	0.60
ATXN3	activates	gene	0.60
PI3K	expressed_in	gene	0.60
APP	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Rhythm Entrainment of Reactive Astrocytes	0.722	neurodegeneration	Astrocyte reactivity subtypes in neurode
BMAL1-CLOCK regulation of miR-143/145 locks microglia into g	0.389	neuroinflammation	Do microglia actually switch between gly

Mentioning Analyses (8)

Scientific analyses that reference this entity

Experiments (6)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Circadian gene expression effects of SD vs ketamine	exploratory	depression	0.950	0.00	C57BL/6J mice	proposed	N/A
CLOCK/BMAL1 regulation of ICC autophagy in GERD model	exploratory	gastroesophageal reflux diseas	0.900	0.00	primary esophageal interstitia	proposed	N/A
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168]	Ruan W, Li T, Bang IH, Lee J, Deng W, Ma	Nature	2025	1
Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923]	Fernandes M, Liguori C	Handb Clin Neurol	2025	1
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504]	Hussain Y, Dar MI, Pan X	Metabolites	2024	1
Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017]	Zeng Y, Guo Z, Wu M, Chen F, Chen L	Cell Death Discov	2024	1
Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594]	Pan X, Mota S, Zhang B	Adv Exp Med Biol	2020	1
BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/ [PMID:41909150]	Zhang D, Wang H, Gu Z, Zhang L, Hu Z, Wa	Biochemistry and biophysics re	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0
Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway-Brief [PMID:41608773]	He M, Sun Y, Tang C, Huang F, Zhu Z et a	Arterioscler Thromb Vasc Biol	2026	0
Liver-specific knockout of CD73 exacerbated alcohol-associated steatohepatitis b [PMID:41833677]	Wu X, Zhang Q, Wang QQ, Liu ZN, Ni YY et	Int J Biol Macromol	2026	0
Circadian disruption and its clinical implications in Parkinson's disease: A Nar [PMID:41905255]	Kataoka H, Saeki K, Sugie K, Obayashi K	Sleep medicine	2026	0
The neuroprotective role of eugenol against glyphosate-induced toxicity in rats: [PMID:41922126]	Bolat İ, Alat Ö, Orhan B, Dereli E, Teki	Tissue & cell	2026	0
Circadian abnormalities, molecular clock gene and chronobiological treatment for [PMID:41913359]	Chakraborty S, Srivastava V	Chronobiology international	2026	0
The rhythm of decline: Circadian disruption in neurodegeneration. [PMID:41066745]	Singh J, Kumar D, Kaur J, Singh A	Journal of food and drug analy	2025	0
Core Circadian Protein BMAL1: Implication for Nervous System Functioning and Its [PMID:41440117]	Smirnova KV, Smirnova LP, Amstislavskaya	Brain sciences	2025	0
Pharmacological targeting of BMAL1 modulates circadian and immune pathways. [PMID:40133642]	Pu H, Bailey LC, Bauer LG, Voronkov M, B	Nature chemical biology	2025	0
Circadian Rhythm Dysfunction in Neurodegenerative Diseases: A Bidirectional Pers [PMID:41287625]	Namgyal D, Lim CS	Nature and science of sleep	2025	0
Disrupted circadian control promotes oncogenesis in breast cancer. [PMID:41908013]	Fatima Y, Kashif M, Jain PA	Bioinformation	2025	0
Disruption of the circadian clock component BMAL1 elicits an endocrine adaption [PMID:35238641]	Jouffe C, Weger BD, Martin E, Atger F, W	Proceedings of the National Ac	2022	0

Debates (10)

Multi-agent debates referencing this entity

BMAL1

Understanding Entity Pages

Summary

Wiki Pages (3)

BMAL1 (ARNTL) Gene

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

BMAL1 Protein

Pathway Diagram

Outgoing (996)

Incoming (400)

Targeting Hypotheses (2)

Mentioning Analyses (8)

What neural circuits encode and maintain multi-generational migratory route memo

Epigenetic reprogramming in aging neurons

Senescent cell clearance as neurodegeneration therapy

Sleep disruption as cause and consequence of neurodegeneration

Neuroinflammation resolution mechanisms and pro-resolving mediators

Digital biomarkers and AI-driven early detection of neurodegeneration

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

Astrocyte reactivity subtypes in neurodegeneration

Experiments (6)

Related Papers (20)

Debates (10)

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

Investigate the therapeutic potential of clearing senescent cells (senolytics) t

Epigenetic reprogramming in aging neurons

Astrocyte reactivity subtypes in neurodegeneration

The paper describes memory-based migration routes maintained across generations

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

Sleep disruption as cause and consequence of neurodegeneration

Senescent cell clearance as neurodegeneration therapy