gene

MAPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

890Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAPK1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 273 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	MAPK1
Protein Family	MAP kinase family, CMGC group
Protein Type	Kinase
Function	is a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular Localization	Cytoplasm, nucleus
Molecular Weight	41 kDa
Amino Acids	360 aa
Pathways	MAPK, Mapk, MAPK signaling, MAPK pathway
UniProt ID	P28482
GeneCards	MAPK1
Human Protein Atlas	MAPK1
Associated Diseases	Aging, Als, Alzheimer, Cancer, Carcinoma
Known Drugs/Compounds	Chrysotoxine, DEP, DMP, DOP, Zuojin Pill
Interactions	ACTB, ACTG1, Actin, ACVR1, AIFM1, AKT
KG Connections	889 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAPK1 — AlphaFold P28482 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts"| APP["APP"]
    MAPK1 -->|"inhibits"| Inflammation["Inflammation"]
    MAPK1 -->|"inhibits"| Als["Als"]
    MAPK1 -->|"inhibits"| Ms["Ms"]
    MAPK1 -->|"activates"| Dementia["Dementia"]
    MAPK1 -->|"activates"| Alzheimer["Alzheimer"]
    MAPK1 -->|"target for"| Cancer["Cancer"]
    FOXO3["FOXO3"] -->|"inhibits"| MAPK1
    PI3K["PI3K"] -->|"inhibits"| MAPK1
    APP -->|"activates"| MAPK1
    NFKB1["NFKB1"] -->|"target for"| MAPK1
    ERK["ERK"] -->|"target for"| MAPK1
    TRIM24["TRIM24"] -->|"target for"| MAPK1
    TDP1["TDP1"] -->|"target for"| MAPK1
    MAP1LC3B["MAP1LC3B"] -->|"inhibits"| MAPK1

Outgoing (541)

Target	Relation	Type	Str
MAPK1	encodes	protein	0.00
Neurodegeneration	involved_in	process	0.90
Breast Cancer	involved_in	disease	0.90
Mapk	therapeutic_target	pathway	0.90
TP53	interacts_with	protein	0.89
Breast Cancer Pathogenesis	involved_in	process	0.85
immunosuppression	upstream_of	process	0.85
Zuojin Pill	inhibits	drug	0.80
Wnt signaling	participates_in	pathway	0.80
Hepatocellular Carcinoma	activates	disease	0.80
GENES	therapeutic_target	gene	0.80
Mapk	activates	pathway	0.80
AKT	therapeutic_target	gene	0.80
Cancer	therapeutic_target	disease	0.75
Als	interacts_with	disease	0.75
APP	interacts_with	protein	0.71
Apoptosis	therapeutic_target	pathway	0.70
PIK3CA	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
PI3K	treats	gene	0.70
Mapk	associated_with	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
PIK3CA	targets	gene	0.70
apoptosis pathway	participates_in	pathway	0.70
Mapk	interacts_with	pathway	0.70
STAT3	associated_with	gene	0.70
NETO2	activates	gene	0.70
Nf-Κb	therapeutic_target	pathway	0.70
Autophagy	activates	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
ALS	expressed_in	disease	0.65
Depression	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Hepatitis	associated_with	disease	0.65
ALS	causes	disease	0.65
Aging	regulates	disease	0.65
Depression	activates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	activates	disease	0.65
Inflammation	causes	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	activates	disease	0.65
Dementia	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Fibrosis	causes	disease	0.65
Dementia	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (349)

Source	Relation	Type	Str
MAPK1	encodes	gene	0.00
Cyclosporine A	upregulates	drug	0.92
FGF2	activates	protein	0.90
DEP	binds	compound	0.90
KDEL	phosphorylates	receptor	0.88
DMP	binds	compound	0.85
DOP	binds	compound	0.85
FGF2 mutant (K119E/R120E/K125E)	inhibits	protein	0.85
PRKCD	associated_with	gene	0.80
Chrysotoxine	targets	compound	0.80
TERT	activates	gene	0.80
EGFR	activates	gene	0.80
PI3K	therapeutic_target	gene	0.80
MYC	associated_with	gene	0.78
MTOR	interacts_with	protein	0.75
MAPK3	therapeutic_target	gene	0.70
NFE2L2	interacts_with	gene	0.70
MAPK3	associated_with	gene	0.70
MAPK3	activates	gene	0.70
FN1	interacts_with	gene	0.60
MAPK	causes	gene	0.60
IL-17	therapeutic_target	gene	0.60
DEPRESSION	inhibits	gene	0.60
ROS	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
MAPK	treats	gene	0.60
NFKB1	therapeutic_target	gene	0.60
TRIM24	therapeutic_target	gene	0.60
TDP1	therapeutic_target	gene	0.60
MAPK3	regulates	gene	0.60
MMP9	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
ERK1	associated_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PSMD14	interacts_with	gene	0.60
KRAS	therapeutic_target	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
MAPK	activates	gene	0.60
RXRA	regulates	gene	0.60
AKT1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK1 in their description or question text

No additional research found

MAPK1

Understanding Entity Pages

Summary

Wiki Pages (12)

MAPK1 Gene

MAPK10 Gene

MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)

JNK3 (MAPK10)

MAPK10 Protein (JNK3)

ERK2 (MAPK1)

MAPK14 Protein

MAPK11 Protein (p38β)

MAPK11

MAPK13 — Mitogen-Activated Protein Kinase 13

MAPK12

MAPK1 Protein (ERK2)