gene

ICAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ICAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

413Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ICAM1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 220 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ICAM1
Full Name	Intercellular Adhesion Molecule 1
Chromosome	19p13.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	23 aa
UniProt ID	P05362
NCBI Gene ID	3383
Ensembl ID	ENSG00000090339
GeneCards	ICAM1
Human Protein Atlas	ICAM1
Associated Diseases	Als, Alzheimer, Chronic Obstructive Pulmonary Disease, Fibrosis, Ms
Interactions	ABCD1, ABCD2, ADAMTS1, AMPK, AND, ANXA2
KG Connections	413 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ICAM1 — AlphaFold P05362 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ICAM1 - Intercellular Adhesion Molecule 1

gene · 1496 words

→

ICAM1 Protein

protein · 1390 words

→

Pathway Diagram

graph TD
    ICAM1["ICAM1"] -->|"activates"| Inflammation["Inflammation"]
    ICAM1["ICAM1"] -->|"activates"| Anxiety["Anxiety"]
    ICAM1["ICAM1"] -->|"activates"| Als["Als"]
    ICAM1["ICAM1"] -->|"activates"| Tumor["Tumor"]
    ICAM1["ICAM1"] -->|"activates"| Depression["Depression"]
    ICAM1["ICAM1"] -->|"activates"| Ms["Ms"]
    CRY1["CRY1"] -->|"activates"| ICAM1["ICAM1"]
    BMAL1["BMAL1"] -->|"activates"| ICAM1["ICAM1"]
    ARNT["ARNT"] -->|"activates"| ICAM1["ICAM1"]
    TNF["TNF"] -->|"activates"| ICAM1["ICAM1"]
    style ICAM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (310)

Target	Relation	Type	Str
Monocyte Adherence	promotes	process	0.85
podocyte detachment	mediates	phenotype	0.85
monocyte migration	mediates	process	0.80
neuroinflammation	involved_in	process	0.80
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.80
Multiple Sclerosis	implicated_in	disease	0.80
oxidative stress response	participates_in	pathway	0.80
Atherosclerosis	therapeutic_target	disease	0.75
Inflammation	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
neuroinflammation	biomarker_for	process	0.72
INFLAMMATION	therapeutic_target	gene	0.70
INFLAMMATION	activates	gene	0.70
CYTOKINES	therapeutic_target	gene	0.70
Stroke	activates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Anxiety	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Ischemia	activates	disease	0.65
Diabetes	activates	disease	0.65
Ulcerative Colitis	therapeutic_target	disease	0.65
Heart Failure	activates	disease	0.65
Cardiac	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Depression	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Anxiety	contributes_to	disease	0.65
ALS	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	contributes_to	disease	0.65
Ms	expressed_in	disease	0.65
Als	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Coronary Artery Disease	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65

Incoming (103)

Source	Relation	Type	Str
AΒ1-42	alters	compound	0.80
SNCA	alters	gene	0.80
CAV1	interacts_with	gene	0.60
MAPK3	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
IBA1	activates	entity	0.60
TDP-43	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
HIF1A	associated_with	gene	0.60
GENES	associated_with	gene	0.60
BCL-2	inhibits	gene	0.60
DNM1L	activates	gene	0.60
NF-ΚB	therapeutic_target	gene	0.60
STROKE	therapeutic_target	gene	0.60
CXCL10	associated_with	gene	0.60
TNF	associated_with	gene	0.60
BAX	inhibits	gene	0.60
CXCL2	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
VCAM1	associated_with	gene	0.60
RAGE	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
KDR	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
FGF2	associated_with	gene	0.60
IL13	associated_with	gene	0.60
HPSE	associated_with	gene	0.60
PCK1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HPSE	activates	gene	0.60
ADAMTS1	interacts_with	gene	0.60
HPSE	interacts_with	gene	0.60
ESM1	associated_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
CCL2	activates	gene	0.60
CRY1	activates	gene	0.60
BMAL1	activates	gene	0.60
ARNT	activates	gene	0.60
TNF	activates	gene	0.60
TNFRSF1A	activates	gene	0.60
OCLN	activates	gene	0.60
CXCL8	inhibits	gene	0.60
CXCL8	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ICAM1 in their description or question text

No additional research found