gene

PARK6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PARK6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

29Outgoing

16Incoming

0Experiments

0Debates

Summary

PARK6 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Als, Inflammation, Ms. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PINK1
Full Name	PTEN Induced Kinase 1
Chromosome	1p36.12
Protein Family	Serine/threonine kinase family
Protein Type	Kinase
Function	is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary Expression	Mitochondrial outer membrane
Subcellular Localization	the outer mitochondrial membrane and plays a critical role in mitochondrial quality control through the activation of pa
Molecular Weight	63 kDa
Pathways	Amyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt ID	Q9BXM7
NCBI Gene ID	65018
Ensembl ID	ENSG00000158828
OMIM	608309
GeneCards	PINK1
Human Protein Atlas	PINK1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	BGP-15, Canagliflozin, CANAGLIFLOZIN, DEFERIPRONE, dimethyl fumarate, Gastrodin
Interactions	ABCD3, ABP, ACHE, Actin, AD, AGING
SciDEX Hypotheses	Mitophagy collapse via PINK1-PRKN is the primary a Dose-Response Framework: PINK1/Parkin Mitophagy as PINK1/PARK2-Mediated Mitophagy Enhancement for Neu (+2 more)
KG Connections	3545 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PINK1 — PTEN Induced Kinase 1 (PARK6)

gene · 552 words

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Pathway Diagram

graph TD
    PARK6["PARK6"]
    Parkinson{"Parkinson"}
    PARK6 -->|"associated with"| Parkinson
    Ms{"Ms"}
    PARK6 -->|"regulates"| Ms
    Neuroinflammation{"Neuroinflammation"}
    PARK6 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    PARK6 -->|"regulates"| Inflammation
    MITOPHAGY["MITOPHAGY"]
    PARK6 -->|"regulates"| MITOPHAGY
    MAPK8["MAPK8"]
    PARK6 -->|"regulates"| MAPK8
    ASTROCYTES["ASTROCYTES"]
    PARK6 -->|"regulates"| ASTROCYTES
    NFKBIA["NFKBIA"]
    PARK6 -->|"regulates"| NFKBIA
    GFAP["GFAP"]
    PARK6 -->|"regulates"| GFAP
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    PARK6 -->|"regulates"| NEUROINFLAMMATION
    PINK1["PINK1"]
    PARK6 -->|"associated with"| PINK1
    Er_Stress(["Er Stress"])
    PARK6 -->|"regulates"| Er_Stress
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| PARK6
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"regulates"| PARK6
    UBE3A["UBE3A"]
    UBE3A -->|"regulates"| PARK6
    CREB3["CREB3"]
    CREB3 -->|"regulates"| PARK6
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"regulates"| PARK6
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| PARK6
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"regulates"| PARK6
    style PARK6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.75
ALS	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Als	associated_with	disease	0.65
PRKN	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
PARK7	causes	gene	0.60
PINK1	causes	gene	0.60
SNCA	causes	gene	0.60
MAPK8	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
GFAP	regulates	gene	0.60
PINK1	associated_with	gene	0.60
Mapk	regulates	pathway	0.60
Mitochondrial Function	associated_with	pathway	0.60
PARK2	associated_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
Innate Immunity	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Er Stress	regulates	pathway	0.60
Neuron	expressed_in	cell_type	0.55
Substantia Nigra	expressed_in	brain_region	0.55
neurons	expressed_in	cell_type	0.55

Incoming (16)

Source	Relation	Type	Str
PINK1	associated_with	gene	0.60
PARK2	associated_with	gene	0.60
HSP90	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
UBE3A	regulates	gene	0.60
CREB3	regulates	gene	0.60
PARKIN	associated_with	gene	0.60
UBIQUITIN	regulates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
MICROGLIA	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
LRRK2	causes	gene	0.60
PARK2	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PARK6 in their description or question text

No additional research found