gene

NFKB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

411Connections

1Hypotheses

6Analyses

50Outgoing

50Incoming

2Experiments

9Debates

Summary

NFKB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with ALS, Als, Alzheimer. Connected to 162 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB p105/p50 Protein
Aliases	NFKB1
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Als, Alzheimer, Alzheimer'S Disease, Cancer, Carcinoma
Known Drugs/Compounds	Berberine, Electroacupuncture, Xiyangshen Sanqi Danshen Granules
Interactions	ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND
SciDEX Hypotheses	Dual NF-κB/MMP Inhibition Strategy
KG Connections	411 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: NFKB1 — AlphaFold P19838 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NF-κB p105/p50 Protein

protein · 613 words

→

NFKB1 Gene

gene · 607 words

→

Pathway Diagram

graph TD
    NFKB1["NFKB1"]
    NFKB1 -->|"activates"| IL8["IL8"]
    NFKB1 -->|"regulates"| CD200R1["CD200R1"]
    NFKB1 -->|"regulates"| TNF["TNF"]
    NFKB1 -->|"regulates"| IL1B["IL1B"]
    NFKB1 -->|"regulates"| microglial_inflammation["microglial inflammation"]
    NFKB1 -->|"regulates"| inflammation["inflammation"]
    NFKB1 -->|"target for"| Cancer["Cancer"]
    NFKB1 -->|"target for"| Als["Als"]
    NFKB1 -->|"target for"| Ms["Ms"]
    NFKB1 -->|"target for"| Inflammation["Inflammation"]
    hyperoxia["hyperoxia"] -->|"activates"| NFKB1
    TNF -->|"activates"| NFKB1
    TRAF6["TRAF6"] -->|"activates"| NFKB1
    DZSM["DZSM"] -->|"regulates"| NFKB1
    BCL2["BCL2"] -->|"target for"| NFKB1
    MTOR["MTOR"] -->|"target for"| NFKB1
    PI3K["PI3K"] -->|"target for"| NFKB1
    AKT["AKT"] -->|"target for"| NFKB1
    EGFR["EGFR"] -->|"target for"| NFKB1
    INFLAMMATION["INFLAMMATION"] -->|"target for"| NFKB1

Outgoing (254)

Target	Relation	Type	Str
C3	activates	gene	0.95
SASP	promotes	process	0.95
Neuroinflammation	upregulates	process	0.90
Neuroinflammation	activates	process	0.90
Inflammation	causes	process	0.90
Pro-Inflammatory Cytokines	upregulates	compound	0.90
IL6	activates	gene	0.90
Tnf-Α	upregulates	protein	0.90
NLRP3	regulates	gene	0.90
Tnf-Α/Nf-Κb/Mapk Signaling Pathway	involved_in	pathway	0.90
Dopamine Neuron Survival	inhibits	phenotype	0.90
Pro-inflammatory Pathways	activates	pathway	0.90
Pro-Inflammatory Pathways	activates	pathway	0.90
inflammatory activation	mediates	process	0.87
GFAP	regulates	gene	0.85
PARKINSON'S DISEASE	biomarker_for	disease	0.85
Neuroinflammation	promotes	process	0.85
ALZHEIMER'S DISEASE	biomarker_for	disease	0.85
MMP2	upregulates	protein	0.85
inflammatory response	drives	process	0.85
MMP9	upregulates	protein	0.85
TP53	regulates	protein	0.85
Mir125B	activates	biomarker	0.85
NF-kB signaling	participates_in	pathway	0.80
Alzheimer's Disease	contributes_to	disease	0.80
Cytoprotection	involved_in	process	0.80
Lipid Metabolism	regulates	process	0.80
Alzheimer's Disease	activates	disease	0.80
Cytoprotective Proteins	upregulates	process	0.80
IL8	activates	gene	0.80
Inflammation	associated_with	process	0.80
Alzheimer'S Disease	associated_with	disease	0.80
Cognitive Protection	involved_in	process	0.80
Cognitive Function	involved_in	phenotype	0.80
lipid metabolism dysregulation	drives	process	0.80
Steroid Hormone Effects	involved_in	mechanism	0.80
Als	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cognitive Impairment Protection	mediates	mechanism	0.75
microglial inflammation	regulates	process	0.70
inflammation	regulates	process	0.70
Mapk	therapeutic_target	pathway	0.70
IL1B	regulates	protein	0.70
TNF	regulates	protein	0.70
KCNK2	interacts_with	gene	0.70
CTNNB1	associated_with	gene	0.69
Ms	expressed_in	disease	0.65
Cancer	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65

Incoming (157)

Source	Relation	Type	Str
h-immunity-6e54942b	relates_to	hypothesis	0.00
Berberine	inhibits	compound	0.95
Nfkbia	inhibits	protein	0.95
TGM2	drives	protein	0.90
Electroacupuncture	inhibits	drug	0.90
IKBA	suppresses	protein	0.90
MYDD88	activates	protein	0.90
h-646ae8f1	targets	hypothesis	0.90
HVCN1	activates	gene	0.90
ROS overproduction	activates	process	0.88
Tg2-In1	suppresses	drug	0.85
Theranekron	downregulates	drug	0.85
AMPK	inhibits	protein	0.85
TLR4	activates	protein	0.85
APP	activates	gene	0.80
SIRT1	inhibits	protein	0.80
Xiyangshen Sanqi Danshen Granules	inhibits	drug	0.80
hyperoxia	activates	phenotype	0.80
NR1D1	represses	gene	0.70
TNF	activates	protein	0.70
DZSM	regulates	drug	0.70
EGFR	therapeutic_target	gene	0.70
PI3K	therapeutic_target	gene	0.70
CASP3	therapeutic_target	gene	0.70
TRAF6	activates	protein	0.70
PINK1	phosphorylates	gene	0.65
LRRK2	co_discussed	gene	0.65
CASP1	targets	gene	0.60
IFNG	associated_with	gene	0.60
IL6	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
IL1B	targets	gene	0.60
TNF	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
AND	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
IL-18	associated_with	gene	0.60
ESR1	regulates	gene	0.60
ATF3	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
TLR4	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Dual NF-κB/MMP Inhibition Strategy	0.554	-	Blood-brain barrier tight junction disru

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Resveratrol protection against renal I/R injury in diabetic rats	validation	diabetic nephropathy	0.900	0.00	streptozotocin-induced diabeti	proposed	N/A
Resveratrol effects on HK-2 cells under hypoxia/reoxygenation	exploratory	diabetic nephropathy	0.850	0.00	HK-2 cells cultured in high gl	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (9)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning NFKB1 in their description or question text

No additional research found

NFKB1

Understanding Entity Pages

Summary

Wiki Pages (2)

NF-κB p105/p50 Protein

NFKB1 Gene

Pathway Diagram

Outgoing (254)

Incoming (157)

Targeting Hypotheses (1)

Mentioning Analyses (6)

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

Can circadian interventions reverse microglial priming independent of sleep disr

Neuroinflammation and microglial priming in early Alzheimer's Disease

Immune atlas neuroinflammation analysis in neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (2)

Related Papers (0)

Debates (9)

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

The fundamental premise remains unvalidated despite extensive mechanistic specul

The fundamental premise remains unvalidated despite extensive mechanistic specul

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

Investigate mechanistic links between early microglial priming states, neuroinfl

Investigate mechanistic links between early microglial priming states, neuroinfl

Can circadian interventions reverse microglial priming independent of sleep disr

Comprehensive analysis of immune cell subtypes in neurodegeneration: microglia s

Related Research