gene

GUCY1B1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUCY1B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

21Outgoing

7Incoming

0Experiments

0Debates

Summary

GUCY1B1 encodes the beta subunit of soluble guanylate cyclase, which heterodimerizes with GUCY1A1 to form the NO-responsive enzyme that produces cGMP, critical for neurovascular function, synaptic plasticity, and implicated in Alzheimer's, Parkinson's, and cerebrovascular disease.

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🧬 Gene Info

Gene Symbol	GUCY1B1
Full Name	Guanylate Cyclase 1 Soluble Subunit Beta 1
Chromosome	4q31.3
Protein Family	Soluble guanylate cyclase subunits (GUCY1A1, GUCY1B1)
Protein Type	Enzyme - Guanylate cyclase
Function	The α₁β₁ sGC heterodimer performs multiple essential functions
Primary Expression	Both cytosolic and membrane-associated fractions, with the heterodimer distributed throughout the cytoplasm and in proximity to the plasma membrane
Subcellular Localization	Both cytosolic and membrane-associated fractions, with the heterodimer distributed throughout the cytoplasm and in proxi
Amino Acids	619 aa
Pathways	Amyloid
UniProt ID	P21452
NCBI Gene ID	2983
Ensembl ID	ENSG00000147862
OMIM	139397
GeneCards	GUCY1B1
Human Protein Atlas	GUCY1B1
Associated Diseases	neurodegeneration
KG Connections	28 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GUCY1B1 — AlphaFold P21452 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GUCY1B1 Gene

gene · 1829 words

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Pathway Diagram

graph TD
    GUCY1B1["GUCY1B1"]
    Alzheimer["Alzheimer"]
    GUCY1B1 -->|"regulates"| Alzheimer
    NFKBIA["NFKBIA"]
    GUCY1B1 -->|"regulates"| NFKBIA
    GENETIC_RISK_LOCI["GENETIC RISK LOCI"]
    GUCY1B1 -->|"regulates"| GENETIC_RISK_LOCI
    ALZHEIMER["ALZHEIMER"]
    GUCY1B1 -->|"regulates"| ALZHEIMER
    MEF2C["MEF2C"]
    GUCY1B1 -->|"expressed in"| MEF2C
    RBFOX2["RBFOX2"]
    GUCY1B1 -->|"expressed in"| RBFOX2
    RNA["RNA"]
    GUCY1B1 -->|"regulates"| RNA
    AND["AND"]
    GUCY1B1 -->|"expressed in"| AND
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    GUCY1B1 -->|"regulates"| ALZHEIMER_S_DISEASE
    AMYLOID["AMYLOID"]
    GUCY1B1 -->|"regulates"| AMYLOID
    TAU["TAU"]
    GUCY1B1 -->|"regulates"| TAU
    Amyloid["Amyloid"]
    GUCY1B1 -->|"regulates"| Amyloid
    NFKBIA["NFKBIA"]
    NFKBIA -->|"regulates"| GUCY1B1
    RBFOX2["RBFOX2"]
    RBFOX2 -->|"expressed in"| GUCY1B1
    TAU["TAU"]
    TAU -->|"regulates"| GUCY1B1
    MEF2C["MEF2C"]
    MEF2C -->|"expressed in"| GUCY1B1
    Cortex["Cortex"]
    GUCY1B1 -->|"expressed in"| Cortex
    Cerebellum["Cerebellum"]
    GUCY1B1 -->|"expressed in"| Cerebellum
    MEF2C["MEF2C"]
    GUCY1B1 -->|"co discussed"| MEF2C
    NFKBIA["NFKBIA"]
    GUCY1B1 -->|"co discussed"| NFKBIA
    RBFOX2["RBFOX2"]
    GUCY1B1 -->|"co discussed"| RBFOX2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| GUCY1B1
    AMYLOID["AMYLOID"]
    AMYLOID -->|"regulates"| GUCY1B1
    RNA["RNA"]
    RNA -->|"regulates"| GUCY1B1
    neurodegeneration["neurodegeneration"]
    GUCY1B1 -->|"implicated in"| neurodegeneration

Outgoing (21)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Rb	expressed_in	protein	0.60
ALZHEIMER	regulates	gene	0.60
RNA	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
Amyloid	regulates	pathway	0.60
Nfkb	regulates	protein	0.60
GENETIC RISK LOCI	regulates	gene	0.60
hippocampus	expressed_in	brain_region	0.60
NFKBIA	regulates	gene	0.60
MEF2C	expressed_in	gene	0.60
RBFOX2	expressed_in	gene	0.60
TAU	regulates	gene	0.60
Cortex	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
MEF2C	co_discussed	gene	0.50
NFKBIA	co_discussed	gene	0.50
RBFOX2	co_discussed	protein	0.50
MEF2C	associated_with	gene	0.50
RBFOX2	associated_with	protein	0.50

Incoming (7)

Source	Relation	Type	Str
NFKBIA	regulates	gene	0.60
RBFOX2	expressed_in	gene	0.60
TAU	regulates	gene	0.60
MEF2C	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.50
AMYLOID	regulates	gene	0.50
RNA	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GUCY1B1 in their description or question text

No additional research found