gene

FLNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

25Outgoing

10Incoming

0Experiments

0Debates

Summary

FLNA is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, implicated in. Associated with Als. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FLNA
Full Name	Filamin A
Chromosome	Xq28
Function	FLNA (Filamin A) is a 280 kDa actin-binding protein that serves as a critical scaffold for protein-protein interactions in eukaryotic cells[@stossel2001]
Molecular Weight	280 kDa
Pathways	Leading Edge Extension
UniProt ID	[P21333](https://www.uniprot.org/uniprot/P21333)
Ensembl ID	ENSG00000196924
OMIM	300017
GeneCards	FLNA
Human Protein Atlas	FLNA
N-terminal actin-binding domain	Binds to F-actin
24 repeat repeats	Each containing two calponin homology (CH) domains that serve as protein interaction surfaces
C-terminal dimerization domain	Enables orthogonal network formation
Associated Diseases	Heterotopic Neurons
Interactions	G3BP1, OPTN, RNA
KG Connections	35 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FLNA Gene

gene · 1225 words

→

Filamin A (FLNA)

protein · 662 words

→

Pathway Diagram

graph TD
    FLNA["FLNA"]
    Als{"Als"}
    FLNA -->|"biomarker for"| Als
    CTSD["CTSD"]
    FLNA -->|"biomarker for"| CTSD
    MIRNAS["MIRNAS"]
    FLNA -->|"biomarker for"| MIRNAS
    JUNB["JUNB"]
    FLNA -->|"biomarker for"| JUNB
    NFKBIA["NFKBIA"]
    FLNA -->|"biomarker for"| NFKBIA
    Apoptosis(["Apoptosis"])
    FLNA -->|"biomarker for"| Apoptosis
    Mapk(["Mapk"])
    FLNA -->|"biomarker for"| Mapk
    TNF["TNF"]
    FLNA -->|"biomarker for"| TNF
    STXBP2["STXBP2"]
    FLNA -->|"biomarker for"| STXBP2
    TRAF6["TRAF6"]
    FLNA -->|"biomarker for"| TRAF6
    EGR2["EGR2"]
    FLNA -->|"biomarker for"| EGR2
    SPI1["SPI1"]
    FLNA -->|"biomarker for"| SPI1
    TRAF6 -->|"biomarker for"| FLNA
    P38["P38"]
    P38 -->|"biomarker for"| FLNA
    CD4["CD4"]
    CD4 -->|"biomarker for"| FLNA
    EGR2 -->|"biomarker for"| FLNA
    TNF -->|"biomarker for"| FLNA
    SPI1 -->|"biomarker for"| FLNA
    GENES["GENES"]
    GENES -->|"biomarker for"| FLNA
    STXBP2 -->|"biomarker for"| FLNA
    style FLNA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:FLNA	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
neuronal migration	regulates	process	0.90
OPTN	interacts_with	gene	0.87
Leading Edge Extension	involved_in	process	0.85
Heterotopic Neurons	causes	phenotype	0.80
Als	biomarker_for	disease	0.65
MIRNAS	biomarker_for	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
Mapk	biomarker_for	pathway	0.60
APOPTOSIS	biomarker_for	gene	0.60
oxidative stress response	participates_in	pathway	0.60
RNA	interacts_with	gene	0.60
CTSD	biomarker_for	gene	0.60
JUNB	biomarker_for	gene	0.60
NFKBIA	biomarker_for	gene	0.60
G3BP1	activates	gene	0.60
G3BP1	interacts_with	gene	0.60
G3BP1	regulates	gene	0.60
TRAF6	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:FLNA	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
TRAF6	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CD4	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FLNA in their description or question text

No additional research found