gene

TNFRSF1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

155Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

TNFRSF1A (TNFR1) - TNF receptor in neuroinflammation and neurodegeneration

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🧬 Gene Info

Gene Symbol	TNFRSF1A
Full Name	Tumor necrosis factor receptor superfamily member 1A
Aliases	TNFR1
Chromosome	12p13.31
Function	TNFRSF1A encodes TNFR1, a receptor that plays central roles in inflammation and cell survival:
Molecular Weight	55 kDa
Amino Acids	455 aa
Exons	10
Pathways	NF-κB Signaling, NF-κB, MAPK Pathway, MAPK
UniProt ID	P19438
NCBI Gene ID	7132
Ensembl ID	ENSG00000082258
OMIM	191190
GeneCards	TNFRSF1A
Human Protein Atlas	TNFRSF1A
Associated Diseases	Atherosclerosis, Diabetes, Ms
Interactions	AND, ANXIETY, APOPTOSIS, App, ARNT, BMAL1
KG Connections	155 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFRSF1A — AlphaFold P19438 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TNFRSF1A Gene

gene · 611 words

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TNFRSF1A Gene

gene · 2121 words

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Pathway Diagram

graph TD
    TNFRSF1A["TNFRSF1A"]
    TNFRSF1A -->|"activates"| Inflammation["Inflammation"]
    TNFRSF1A -->|"activates"| Anxiety["Anxiety"]
    TNFRSF1A -->|"activates"| Als["Als"]
    TNFRSF1A -->|"activates"| Tumor["Tumor"]
    TNFRSF1A -->|"activates"| Depression["Depression"]
    TNFRSF1A -->|"activates"| Ms["Ms"]
    CRY1["CRY1"] -->|"activates"| TNFRSF1A
    BMAL1["BMAL1"] -->|"activates"| TNFRSF1A
    ARNT["ARNT"] -->|"activates"| TNFRSF1A
    TNF["TNF"] -->|"activates"| TNFRSF1A
    OCLN["OCLN"] -->|"activates"| TNFRSF1A
    ICAM1["ICAM1"] -->|"activates"| TNFRSF1A

Outgoing (99)

Target	Relation	Type	Str
positive_feedback_loops	modulates	mechanism	0.70
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Anxiety	contributes_to	disease	0.65
Depression	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
Ms	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Heart Failure	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Anxiety	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	regulates	disease	0.65
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
cortex	expressed_in	brain_region	0.60
OCLN	activates	gene	0.60
ICAM1	activates	gene	0.60
STAT3	regulates	gene	0.60
NFKBIA	regulates	gene	0.60
CSF1	regulates	gene	0.60
IL6ST	regulates	gene	0.60
FGFR1	regulates	gene	0.60
NFKB2	regulates	gene	0.60
NOTCH2	regulates	gene	0.60
FYCO1	interacts_with	gene	0.60
DR5	activates	gene	0.60
TRAIL	activates	gene	0.60
CASP8	activates	gene	0.60
TNF	interacts_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Circadian Rhythm	activates	pathway	0.60
ALZHEIMER	regulates	gene	0.60
GENES	regulates	gene	0.60
ASTROCYTE	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
Notch	regulates	pathway	0.60

Incoming (56)

Source	Relation	Type	Str
PHF2	regulates	enzyme	0.95
INFLAMMATION	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CRY1	activates	gene	0.60
BMAL1	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
TNF	activates	gene	0.60
IBA1	activates	entity	0.60
TNF	interacts_with	gene	0.60
GAIN	regulates	gene	0.60
ARNT	activates	gene	0.60
NFH	biomarker_for	gene	0.60
APOPTOSIS	regulates	gene	0.60
RUBCNL	interacts_with	gene	0.60
VEGF	associated_with	gene	0.60
JUNB	regulates	gene	0.60
TNF	regulates	gene	0.60
TFRC	associated_with	gene	0.60
CD44	expressed_in	gene	0.60
CASP1	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
TPM3	expressed_in	gene	0.60
RIPK1	expressed_in	gene	0.60
BCL2L1	biomarker_for	gene	0.60
CASP1	associated_with	gene	0.60
NFKBIA	associated_with	gene	0.60
CASP8	biomarker_for	gene	0.60
IL1B	associated_with	gene	0.60
XIAP	biomarker_for	gene	0.60
AKT1	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
CFLAR	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
ANXIETY	activates	gene	0.60
GENES	activates	gene	0.60
MICROGLIA ACTIVATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
DEPRESSION	activates	gene	0.60
CYTOKINES	activates	gene	0.60
OCLN	activates	gene	0.60
ARNT	contributes_to	gene	0.60
BMAL1	contributes_to	gene	0.60
CRY1	contributes_to	gene	0.60
ICAM1	activates	gene	0.60
OCLN	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning TNFRSF1A in their description or question text

No additional research found