gene 1,472 words KG: NFKBIA
Contents

NFKBIA Gene (NFKB Inhibitor Alpha)

🧬 Gene Info
Gene SymbolNFKBIA
Full NameNFKB Inhibitor Alpha
Chromosome14q13
Molecular Weight37 kDa
Amino Acids317 aa
Exons7 exons encoding the IκBα protein
PathwaysNFKB, NF-κB
UniProt IDP19838
NCBI Gene ID4792
Ensembl IDENSG0000096927
OMIM164008
GeneCardsNFKBIA
Human Protein AtlasNFKBIA
PromoterContains NF-κB binding sites, making expression auto-regulatory
3' UTRContains AU-rich elements (AREs) regulating mRNA stability
Associated DiseasesHepatitis, Inflammation, Ms
InteractionsAND, APOPTOSIS, ASTROCYTES, AUTOPHAGY, BMAL1, BNIP3
KG Connections321 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (10)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54

Related Analyses (6)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

Astrocytes
cell · KG edge: inhibits
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: regulates
Astrocytes
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
ADCY9 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

TRAF6 biomarker_for NFKBIA
P38 biomarker_for NFKBIA
CD4 biomarker_for NFKBIA
EGR2 biomarker_for NFKBIA
TNF biomarker_for NFKBIA
SPI1 biomarker_for NFKBIA
STXBP2 biomarker_for NFKBIA
FLNA biomarker_for NFKBIA
CTSD biomarker_for NFKBIA
JUNB biomarker_for NFKBIA

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.