gene 1,540 words KG: JNK1
Contents

JNK1 (MAPK8)

🧬 Gene Info
Gene SymbolJNK1
AliasesMAPK8
Protein TypeKinase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight46 kDa
Amino Acids464 aa
Exons12
Pathwayscascade: **Upstream Activation:**, MAPK, Mapk
Ensembl IDENSG00000107643
GeneCardsJNK1
Human Protein AtlasJNK1
JNK1βLess characterized isoform
Associated DiseasesALS
Known Drugs/Compoundsrapamycin
InteractionsACC, AMPK, AND, ASTROCYTES, ATG5, ATM
KG Connections166 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

acc-chronic-pain
cell_type · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Astrocytes
entity · KG edge: activates
GFAP (Redirect)
redirect · KG edge: activates

Knowledge Graph (12 edges)

JUN activates JNK1
BIP activates JNK1
JNK1 activates JNK2
P38 activates JNK1
JNK2 activates JNK1
JNK1 activates BIP
JNK1 activates JUN
JNK1 activates P38
CXCL1 activates JNK1
GFAP activates JNK1

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