gene 1,509 words KG: MAPK8
Contents

MAPK8 Gene

🧬 Gene Info
Gene SymbolMAPK8
Full NameMitogen-Activated Protein Kinase 8
Chromosome10q11.22.
Protein FamilyMAPK (Mitogen-Activated Protein Kinases)
Protein TypeSerine/Threonine Kinase
Function- Transcription factors: c-Jun, JunB, JunD, ATF2, ELK-1
Molecular Weight46 kDa
Amino Acids427 aa
PathwaysMAPK, NF-κB
UniProt IDP45985
NCBI Gene ID5599
Ensembl IDENSG00000106789
GeneCardsMAPK8
Human Protein AtlasMAPK8
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsPolyphenols, rapamycin
InteractionsABCD3, AKT1, ALS, ALZHEIMER, ALZHEIMER DISEASE, AMBRA1
KG Connections637 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (14)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
PARP1 Inhibition Therapy
Score: 0.74

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (5)

GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: regulates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
AKT1 Gene
gene · KG edge: activates
AMBRA1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAT interacts_with MAPK8
OPTN interacts_with MAPK8
DNM1L interacts_with MAPK8
CANX interacts_with MAPK8
LGALS3 interacts_with MAPK8
CALCOCO2 interacts_with MAPK8
G3BP1 interacts_with MAPK8
PEX3 interacts_with MAPK8
SQSTM1 interacts_with MAPK8
BCL2 interacts_with MAPK8

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