gene

VIM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VIM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

377Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

VIM is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, biomarker for. Associated with ALS, Aging, Als. Connected to 209 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VIM
Full Name	Vimentin
Chromosome	10p13
Function	encodes a type III intermediate filament protein that is one of the most widely expressed structural proteins in eukaryotic cells.
Subcellular Localization	</th><td>Cytoplasm, intermediate filaments, perinuclear region</td></tr>
Molecular Weight	57 kDa
Amino Acids	466 aa
Exons	9
Pathways	Autophagy, Immune Response, Mapk, Notch Signaling, Proteasome
Ensembl ID	ENSG00000026025
OMIM	193060
GeneCards	VIM
Human Protein Atlas	VIM
Length	466 amino acids
Molecular weight	~54 kDa
Associated Diseases	Diabetes, Inflammation, Parkinson, Parkinson's disease
Known Drugs/Compounds	Columbianadin, rapamycin
Interactions	ACTB, AMPK, AND, ANXA2, AQP4, AR
KG Connections	377 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    VIM["VIM
(Vimentin)"]
    
    %% Autophagy pathway
    BECN1["BECN1
(Beclin-1)"]
    MAP1LC3B["MAP1LC3B
(LC3B)"]
    ATG14["ATG14
(Autophagy Protein)"]
    PIK3C3["PIK3C3
(VPS34)"]
    UVRAG["UVRAG
(Autophagy Regulator)"]
    LAMP1["LAMP1
(Lysosomal Protein)"]
    Autophagy["Autophagy
Pathway"]
    
    %% Protein degradation
    UPS["Ubiquitin-Proteasome
System"]
    HDAC6["HDAC6
(Histone Deacetylase)"]
    
    %% Cellular stress
    H2AX["H2AX
(DNA Damage Marker)"]
    MAP3K5["MAP3K5
(ASK1 Kinase)"]
    
    %% Disease outcomes
    Inflammation["Neuroinflammation"]
    Senescence["Cellular
Senescence"]
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    PD["Parkinson's
Disease"]
    MS["Multiple
Sclerosis"]
    
    %% Connections
    VIM -->|"regulates"| BECN1
    VIM -->|"regulates"| ATG14
    VIM -->|"regulates"| Autophagy
    VIM -->|"associated with"| MAP1LC3B
    VIM -->|"associated with"| PIK3C3
    VIM -->|"associated with"| UVRAG
    VIM -->|"associated with"| LAMP1
    VIM -->|"regulates"| UPS
    VIM -->|"associated with"| HDAC6
    VIM -->|"regulates"| H2AX
    VIM -->|"associated with"| MAP3K5
    
    BECN1 -->|"initiates"| Autophagy
    ATG14 -->|"promotes"| Autophagy
    MAP1LC3B -->|"mediates"| Autophagy
    PIK3C3 -->|"activates"| Autophagy
    UVRAG -->|"regulates"| Autophagy
    LAMP1 -->|"completes"| Autophagy
    
    VIM -->|"biomarker for"| Inflammation
    VIM -->|"biomarker for"| Senescence
    VIM -->|"biomarker for"| ALS
    VIM -->|"therapeutic target"| PD
    VIM -->|"therapeutic target"| MS
    
    H2AX -->|"indicates"| Senescence
    MAP3K5 -->|"promotes"| Inflammation
    
    %% Styling
    style VIM fill:#006494
    style Autophagy fill:#1b5e20
    style UPS fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style ATG14 fill:#4a1a6b
    style HDAC6 fill:#4a1a6b
    style Inflammation fill:#ef5350
    style Senescence fill:#ef5350
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style MS fill:#5d4400

Outgoing (178)

Target	Relation	Type	Str
Notch Signaling	regulates	pathway	0.90
Synoviocyte Migration	promotes	phenotype	0.85
VAV2	activates	gene	0.85
Synoviocyte Invasion	promotes	phenotype	0.85
neurodegeneration	involved_in	process	0.75
Aging	biomarker_for	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Inflammation	biomarker_for	disease	0.65
Stroke	activates	disease	0.65
Senescence	biomarker_for	disease	0.65
Longevity	biomarker_for	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	biomarker_for	disease	0.65
Ischemia	activates	disease	0.65
Breast Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Carcinoma	expressed_in	disease	0.65
Prostate Cancer	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Ms	regulates	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	activates	disease	0.65
PARKINSON	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Chaperone	inhibits	pathway	0.60
Metastasis	inhibits	pathway	0.60
DIABETES MELLITUS	associated_with	gene	0.60
Lysosomal Degradation	activates	pathway	0.60
Jak-Stat	inhibits	pathway	0.60
Immune Response	regulates	pathway	0.60
DENND3	associated_with	gene	0.60
MGA	associated_with	gene	0.60

Incoming (199)

Source	Relation	Type	Str
Columbianadin	inhibits	compound	0.95
Columbianadin	binds	compound	0.90
GFAP	associated_with	protein	0.85
SCIN	activates	gene	0.60
TJP1	activates	gene	0.60
CX43	biomarker_for	gene	0.60
GSH	biomarker_for	gene	0.60
CX43	expressed_in	gene	0.60
FGF21	activates	gene	0.60
APP	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
S100B	biomarker_for	gene	0.60
PLAU	activates	gene	0.60
CXCL10	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
SOD2	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
RAC1	therapeutic_target	gene	0.60
MET	therapeutic_target	gene	0.60
MMP9	associated_with	gene	0.60
MMP9	regulates	gene	0.60
GADD45A	regulates	gene	0.60
MAPK14	regulates	gene	0.60
AQP4	activates	gene	0.60
TLR6	activates	gene	0.60
GFAP	activates	gene	0.60
IL1B	activates	gene	0.60
TNF	activates	gene	0.60
PROGRANULIN	activates	gene	0.60
TPM2	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
VIMENTIN	associated_with	gene	0.60
LDH	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
CD31	regulates	gene	0.60
CKB	regulates	gene	0.60
CTS	regulates	gene	0.60
GATA3	regulates	gene	0.60
GLB1	regulates	gene	0.60
IL1RL1	regulates	gene	0.60
IL4	regulates	gene	0.60
IL7R	regulates	gene	0.60
LC3	regulates	gene	0.60
LDH	regulates	gene	0.60
PECAM1	regulates	gene	0.60
RORC	regulates	gene	0.60
SQSTM1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VIM in their description or question text

No additional research found

VIM