| Gene Symbol | MAP3K5 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 5 |
| Chromosome | 6q26 |
| Protein Type | Kinase |
| Function | is a critical MAP3K that activates the JNK and p38 MAPK pathways in response to cellular stress. |
| Molecular Weight | 155 kDa |
| Amino Acids | 374 aa |
| Pathways | MAPK pathway |
| UniProt ID | [Q9UHD6](https://www.uniprot.org/uniprot/Q9UHD6) |
| Ensembl ID | ENSG00000197442 |
| OMIM | 602476 |
| GeneCards | MAP3K5 |
| Human Protein Atlas | MAP3K5 |
| Cerebral cortex | pyramidal neurons |
| Hippocampus | CA1-CA3 regions, dentate gyrus |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACOX1, ACTB, Adiponectin, ADIPOQ, AMPK, AND |
| KG Connections | 284 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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