gene

STK11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STK11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

300Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

STK11 is a gene implicated in neurodegeneration research. Key relationships include: regulates, activates, associated with. Associated with Als, Alzheimer, Ataxia. Connected to 158 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STK11
Full Name	LKB1 (Serine/Threonine Kinase 11)
Aliases	Page for STK11, Page for STK11 Protein
Chromosome	19p13.3
Protein Type	Protein
Function	is a serine/threonine kinase that functions as a master regulator of cellular energy metabolism and stress responses.
Primary Expression	mammalian tissues with particularly high levels in the brain, liver, and skeletal muscle
Subcellular Localization	[@zong2019]
Molecular Weight	48.6 kDa
Amino Acids	433 aa
Exons	9
Pathways	AMPK, AMPK pathway, AMPK Pathway
UniProt ID	Search UniProt
GeneCards	STK11
Human Protein Atlas	STK11
Associated Diseases	ALS, Alzheimer, Cancer, multiple sclerosis, Parkinson
Known Drugs/Compounds	Crocetin, rapamycin
Interactions	ACTB, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	300 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: STK11 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

STK11 Protein - LKB1 - Serine/Threonine Kinase 11

protein · 1356 words

→

STK11 - Serine/Threonine Kinase 11

gene · 907 words

→

Pathway Diagram

graph TD
    STK11["STK11"]
    STK11 -->|"activates"| Alzheimer["Alzheimer"]
    STK11 -->|"contributes to"| Cancer["Cancer"]
    STK11 -->|"contributes to"| Ms["Ms"]
    STK11 -->|"expressed in"| Als["Als"]
    STK11 -->|"inhibits"| Tumor["Tumor"]
    STK11 -->|"regulates"| Ataxia["Ataxia"]
    STK11 -->|"activates"| Carcinoma["Carcinoma"]
    ACTB["ACTB"] -->|"regulates"| STK11
    CDC42["CDC42"] -->|"regulates"| STK11
    CASP3["CASP3"] -->|"regulates"| STK11
    MAPT["MAPT"] -->|"activates"| STK11
    IDH1["IDH1"] -->|"contributes to"| STK11
    VHL["VHL"] -->|"contributes to"| STK11
    MTOR["MTOR"] -->|"contributes to"| STK11
    PTEN["PTEN"] -->|"contributes to"| STK11
    AMPK["AMPK"] -->|"activates"| STK11
    AKT["AKT"] -->|"contributes to"| STK11

Outgoing (171)

Target	Relation	Type	Str
MTOR	inhibits	protein	0.85
MTOR Pathway Activity	inhibits	process	0.85
PI3K/AKT/mTOR	regulates	pathway	0.85
Copy Number Loss	associated_with	mechanism	0.80
Als	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Ataxia	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	contributes_to	disease	0.65
Cancer	implicated_in	disease	0.65
Cancer	contributes_to	disease	0.65
Tumor	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Carcinoma	expressed_in	disease	0.65
PI3K_AKT_MTOR_pathway	regulates	pathway	0.64
LAMP1	associated_with	gene	0.60
GJA1	regulates	gene	0.60
MAP3K5	associated_with	gene	0.60
ATG14	regulates	gene	0.60
PIK3C3	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
BECN1	regulates	gene	0.60
PI3K	contributes_to	gene	0.60
IDH1	contributes_to	gene	0.60
MTOR	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
VHL	contributes_to	gene	0.60
PTEN	inhibits	gene	0.60
RB1	inhibits	gene	0.60
KMT2C	expressed_in	gene	0.60
PTEN	contributes_to	gene	0.60
MAPT	activates	gene	0.60
RAC1	associated_with	gene	0.60
TUBB3	associated_with	gene	0.60
ACTB	regulates	gene	0.60
OCLN	associated_with	gene	0.60
GAPDH	regulates	gene	0.60
ULK1	activates	gene	0.60

Incoming (129)

Source	Relation	Type	Str
Crocetin	activates	compound	0.85
AMPK	activates	gene	0.70
PRKAA1	inhibits	gene	0.60
CANCER	implicated_in	gene	0.60
GENES	implicated_in	gene	0.60
ROS	regulates	gene	0.60
AXIN	activates	gene	0.60
AMPK	inhibits	gene	0.60
TUBULIN	inhibits	gene	0.60
DNA	activates	gene	0.60
KRAS	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ATG	activates	gene	0.60
GFP	activates	gene	0.60
LC3B	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
PTEN	implicated_in	gene	0.60
AURKB	activates	gene	0.60
CDK1	activates	gene	0.60
DDB1	activates	gene	0.60
GLB1	activates	gene	0.60
MTOR	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ALZHEIMER DISEASE	activates	gene	0.60
GENES	contributes_to	gene	0.60
CANCER	contributes_to	gene	0.60
KRAS	expressed_in	gene	0.60
MTORC1	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
GENES	inhibits	gene	0.60
LKB1	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AXON	inhibits	gene	0.60
AND	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
SCIN	activates	gene	0.60
LAMP1	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MAP3K5	activates	entity	0.60
OCLN	activates	entity	0.60
PIK3C3	activates	entity	0.60
RAC1	activates	entity	0.60
WT1	associated_with	gene	0.60
AUTOPHAGY	regulates	gene	0.60
HDAC6	activates	entity	0.60
CYP11A1	activates	gene	0.60
CDC42	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity