gene

CDC42

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDC42: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

423Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CDC42 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, regulates. Associated with Aging, Als, Alzheimer. Connected to 206 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDC42
Full Name	Cell Division Cycle 42
Chromosome	1p36.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	21 kDa
Amino Acids	191 aa
Exons	6
Pathways	Proteasome, Ubiquitin-Proteasome
UniProt ID	[P60953](https://www.uniprot.org/uniprot/P60953)
Ensembl ID	ENSG00000158062
GeneCards	CDC42
Human Protein Atlas	CDC42
GTP-Binding Domain	Five conserved motifs (GxxxxGKST, DxxG, TxxxGKST, xDxx, CAAX box)
Switch I Region	Residues 32-45, conformational change on GTP/GDP binding
Switch II Region	Residues 60-76, effector interaction site
Associated Diseases	Als, Alzheimer, Diabetes, Ferroptosis, Inflammation
Interactions	ACTB, ACTG1, Actin, ACVR1, AGING, AKT
KG Connections	423 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDC42["CDC42"]
    CDC42 -->|"activates"| Cancer["Cancer"]
    CDC42 -->|"activates"| Aging["Aging"]
    CDC42 -->|"activates"| Ms["Ms"]
    CDC42 -->|"target for"| Inflammation["Inflammation"]
    CDC42 -->|"target for"| Parkinson["Parkinson"]
    CDC42 -->|"target for"| Diabetes["Diabetes"]
    CDC42 -->|"target for"| Alzheimer["Alzheimer"]
    STK11["STK11"] -->|"regulates"| CDC42
    PIK3C3["PIK3C3"] -->|"regulates"| CDC42
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| CDC42
    OCLN["OCLN"] -->|"regulates"| CDC42
    VIM["VIM"] -->|"regulates"| CDC42
    LAMP1["LAMP1"] -->|"regulates"| CDC42
    HDAC6["HDAC6"] -->|"regulates"| CDC42
    MET["MET"] -->|"target for"| CDC42
    TPM2["TPM2"] -->|"target for"| CDC42
    CCT2["CCT2"] -->|"interacts"| CDC42

Outgoing (242)

Target	Relation	Type	Str
Parkinson's Disease	involved_in	disease	0.75
Inflammation	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Aging	interacts_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	stabilizes	disease	0.65
Cancer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Aging	stabilizes	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Als	regulates	disease	0.65
Senescence	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Ferroptosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Prion	therapeutic_target	disease	0.65
UBIQUITIN	regulates	gene	0.60
RHOA	inhibits	gene	0.60
Rb	activates	protein	0.60
TH	associated_with	gene	0.60
neurodegeneration	regulates	disease	0.60
Apoptosis	associated_with	pathway	0.60
Angiogenesis	associated_with	pathway	0.60
LYSOSOME	regulates	gene	0.60
RNA	activates	gene	0.60
TUBULIN	regulates	gene	0.60
Egfr	regulates	protein	0.60
CALM1	associated_with	gene	0.60
KIF15	associated_with	gene	0.60

Incoming (181)

Source	Relation	Type	Str
MGA	therapeutic_target	gene	0.60
SOD2	associated_with	gene	0.60
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
SOX2	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAB10	activates	gene	0.60
RAB7A	activates	gene	0.60
PAK1	associated_with	gene	0.60
VIMENTIN	regulates	gene	0.60
RAC1	therapeutic_target	gene	0.60
KIF15	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
AURKB	associated_with	gene	0.60
TPR	associated_with	gene	0.60
RANK	therapeutic_target	gene	0.60
CALM1	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
ERBB2	associated_with	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
MGA	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
AND	interacts_with	gene	0.60
PARKINSON	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AND	regulates	gene	0.60
RAS	regulates	gene	0.60
GENES	expressed_in	gene	0.60
DENND3	therapeutic_target	gene	0.60
ACTB	associated_with	gene	0.60
WT1	regulates	gene	0.60
CYP11A1	associated_with	gene	0.60
CBL	interacts_with	gene	0.60
AKT	interacts_with	gene	0.60
RHOA	interacts_with	gene	0.60
TRAF2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity