protein

VIMENTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VIMENTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

328Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Type III intermediate filament protein expressed in astrocytes, marker of neuroinflammation in neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	VIMENTIN
Chromosome	10p13
Protein Family	Type III intermediate filament protein
Function	is a type III intermediate filament protein encoded by the VIM gene.
Primary Expression	mesenchymal cells, fibroblasts, and astrocytes in the central nervous system
Subcellular Localization	Cytoplasm, intermediate filaments
Molecular Weight	57 kDa
Amino Acids	466 aa
Pathways	Autophagy, NOTCH_SIGNALING, Notch Signal Sending, Notch Signaling, Proteasome
UniProt ID	P08670
GeneCards	VIMENTIN
Human Protein Atlas	VIMENTIN
Central α-helical rod domain	Responsible for dimerization and filament assembly PMID: 2847424
N-terminal head domain	Regulates filament assembly and interaction with signaling molecules PMID: 21855637
C-terminal tail domain	Mediates interactions with other cytoskeletal elements and organelles PMID: 8898344
Associated Diseases	Glioblastoma, Ms, Tumor
Known Drugs/Compounds	columbianadin
Interactions	ACTB, Actin, Akt, AKT, ALPHA-SYNUCLEIN, AND
KG Connections	325 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: VIMENTIN — AlphaFold P08670 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Vimentin - Biomarker

biomarker · 1913 words

→

Pathway Diagram

graph TD
    VIMENTIN["VIMENTIN"]
    VIMENTIN -.biomarker for.-> Aging["Aging"]
    VIMENTIN -.biomarker for.-> Inflammation["Inflammation"]
    VIMENTIN -.biomarker for.-> ALS["ALS"]
    VIMENTIN -.biomarker for.-> Senescence["Senescence"]
    VIMENTIN -.biomarker for.-> Fibrosis["Fibrosis"]
    VIMENTIN -->|"regulates"| NOTCH_SIGNALING["NOTCH_SIGNALING"]
    VIMENTIN -->|"regulates"| ATG14["ATG14"]
    VIMENTIN -->|"regulates"| AUTOPHAGY["AUTOPHAGY"]
    VIMENTIN -->|"regulates"| Proteasome["Proteasome"]
    LYSOSOME["LYSOSOME"] -->|"regulates"| VIMENTIN
    GJA1["GJA1"] -->|"regulates"| VIMENTIN
    CASP3["CASP3"] -->|"regulates"| VIMENTIN
    GAPDH["GAPDH"] -->|"regulates"| VIMENTIN
    ACTB["ACTB"] -->|"regulates"| VIMENTIN
    CDC42["CDC42"] -->|"regulates"| VIMENTIN
    BECN1["BECN1"] -->|"regulates"| VIMENTIN
    H2AX["H2AX"] -->|"regulates"| VIMENTIN
    GPNMB["GPNMB"] -.biomarker for.-> VIMENTIN
    CX3CL1["CX3CL1"] -->|"activates"| VIMENTIN

Outgoing (198)

Target	Relation	Type	Str
Notch Signaling	regulates	pathway	0.85
Notch Signal Sending	regulates	mechanism	0.85
VAV2	activates	protein	0.85
Synoviocyte Invasion	mediates	phenotype	0.83
Notch Signal Sending Competence	modulates	phenotype	0.75
VAV2/Rac-1 signaling pathway	inhibits	pathway	0.70
Glioblastoma	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Cancer	activates	disease	0.65
ALS	transports	disease	0.65
Ms	associated_with	disease	0.65
Als	inhibits	disease	0.65
Tumor	associated_with	disease	0.65
Tumor	activates	disease	0.65
Als	biomarker_for	disease	0.65
Autoimmune	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Als	transports	disease	0.65
Fibrosis	activates	disease	0.65
Als	regulates	disease	0.65
Epilepsy	activates	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Diabetes	activates	disease	0.65
Senescence	biomarker_for	disease	0.65
NOTCH_SIGNALING	regulates	pathway	0.64
PGRN	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
GHRL	biomarker_for	gene	0.60
IGF-1	biomarker_for	gene	0.60
Fibroblast	activates	cell_type	0.60
Neuron	biomarker_for	cell_type	0.60
RNA	associated_with	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
Amyloid	expressed_in	pathway	0.60
AND	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	activates	gene	0.60
Tgf-Β	activates	pathway	0.60
Alpha-Synuclein	activates	pathway	0.60
EPILEPSY	activates	gene	0.60
AND	transports	gene	0.60
DLK2	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60

Incoming (130)

Source	Relation	Type	Str
HIF-1Α	upregulates	gene	0.90
Columbianadin	binds	compound	0.90
columbianadin	targets	compound	0.70
LAMP1	activates	entity	0.60
MAP1LC3B	activates	entity	0.60
MAP3K5	activates	entity	0.60
OCLN	activates	entity	0.60
P62	activates	entity	0.60
PIK3C3	activates	entity	0.60
RAC1	activates	entity	0.60
SQSTM1	activates	entity	0.60
STK11	activates	entity	0.60
TUBB3	activates	entity	0.60
TUBULIN	activates	entity	0.60
UBIQUITIN	activates	entity	0.60
UVRAG	activates	entity	0.60
VIM	interacts_with	gene	0.60
SNCA	activates	gene	0.60
TNF	expressed_in	gene	0.60
MAPK	activates	gene	0.60
HDAC6	activates	entity	0.60
ROS	activates	gene	0.60
TJP1	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
SCIN	associated_with	gene	0.60
ASTROCYTES	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
AMYLOID	expressed_in	gene	0.60
WT1	associated_with	gene	0.60
TUBULIN	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP3K5	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OCLN	associated_with	gene	0.60
GJA1	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
CASP3	regulates	gene	0.60
GAPDH	regulates	gene	0.60
ACTB	regulates	gene	0.60
TUBB3	associated_with	gene	0.60
UVRAG	associated_with	gene	0.60
RAC1	associated_with	gene	0.60
STK11	associated_with	gene	0.60
VIM	associated_with	gene	0.60
CDC42	regulates	gene	0.60
HDAC6	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning VIMENTIN in their description or question text

No additional research found